Plasma Insulin Levels and Hypoglycemia Affect Subcutaneous Interstitial Glucose Concentration
| العنوان: | Plasma Insulin Levels and Hypoglycemia Affect Subcutaneous Interstitial Glucose Concentration |
|---|---|
| المؤلفون: | Carmine G. Fanelli, Paolo Rossetti, Francisco Javier Ampudia-Blasco, Vanessa Moscardó, Paola Lucidi, Jorge Bondia |
| المصدر: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| بيانات النشر: | Mary Ann Liebert, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Hypoglycemia, Interstitial glucose, Subcutaneous glucose sensing, Endocrinology, Diabetes and Metabolism, Endocrinology, Medical Laboratory Technology, Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, 030209 endocrinology & metabolism, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Medicine, Humans, Insulin, skin and connective tissue diseases, 030304 developmental biology, 0303 health sciences, business.industry, Continuous glucose monitoring, nutritional and metabolic diseases, Extracellular Fluid, Middle Aged, medicine.disease, INGENIERIA DE SISTEMAS Y AUTOMATICA, 3. Good health, Diabetes and Metabolism, Diabetes Mellitus, Type 1, Glucose, Female, sense organs, Plasma insulin, business |
| الوصف: | [EN] Background: Continuous glucose monitoring (CGM) accuracy during hypoglycemia is suboptimal. This might be partly explained by insulin or hypoglycemia-induced changes in the plasma interstitial subcutaneous (SC) fluid glucose gradient. The aim of the present study was to assess the role of plasma insulin (PI) and hypoglycemia itself in the plasma and interstitial SC fluid glucose concentration in patients with type 1 diabetes mellitus. Methods: Eleven subjects with type 1 diabetes (age 36.59.1 years, HbA(1c) 7.90.4% [62.8 +/- 2.02mmol/mol]; mean +/- standard deviation) were evaluated under hyperinsulinemic euglycemia and hypoglycemia. Each subject underwent two randomized crossover clamps with either a primed 0.3 (low insulin) or 1mU/(kgmin) (high insulin) insulin infusion. The raw CGM signal was normalized with median preclamp values to obtain a standardized measure of the interstitial glucose (IG) concentration before statistical analysis. Results: The mean PI concentration was greater in high insulin studies (HISs) versus low insulin studies (LISs) (412.89 +/- 13.63 vs. 177.22 +/- 10.05pmol/L). During hypoglycemia, glucagon, adrenaline, free fatty acids, glycerol, and beta-OH-butyrate were higher in the LIS (P The research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007/2013) under the grant agreement 252085 and FEDER funds, as well as the Spanish Ministry of Economy and Competitiveness (MINECO) under the grants DPI2013-46982-C2-1-R and DPI2016-78831-C2-1-R.V.M. is recipient of an FPU grant ref FPU13/04253. We are grateful to Mrs. Sara Correa, Fundacion INCLIVA-Hospital Clinico Universitario de Valencia, and Mrs. Geles Viguer, Hospital Clinico Universitario de Valencia, for their invaluable help in conducting the study. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7455ba758808130ed1ad72531aeb958Test http://hdl.handle.net/10251/138967Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e7455ba758808130ed1ad72531aeb958 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |