المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Cell Biology, Celbiologie

المصدر: Molecular Cell
Molecular Cell, 79(1), 191. Cell Press
Molecular Cell, 79(1), 191-198.e3. Cell Press

مصطلحات موضوعية: Protein Conformation, Mutant, Cell, medicine.disease_cause, Crystallography, X-Ray, Microtubules, 0302 clinical medicine, Tubulin, Neoplasms, Sulfones, Cells, Cultured, Glycine/analogs & derivatives, Mutation, 0303 health sciences, Cultured, Crystallography, biology, Chemistry, rigosertib, Rigosertib, drug mechanism of action, 3. Good health, Cell biology, medicine.anatomical_structure, chemical genetics, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Pharmaceutical Preparations/chemistry, Drug Contamination, Antineoplastic Agents/pharmacology, Cells, Glycine, Antineoplastic Agents, Article, 03 medical and health sciences, CRISPRa, Tubulin/chemistry, Microtubule, medicine, Humans, Binding site, Molecular Biology, 030304 developmental biology, Cell Proliferation, drug target identification, CRISPRi, Cell Biology, In vitro, Neoplasms/drug therapy, Sulfones/pharmacology, Cancer cell, X-Ray, biology.protein, Microtubules/drug effects, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e69dbc0caaaee2c44b7494dfd72fa4Test
https://pubmed.ncbi.nlm.nih.gov/32619469Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Cell Biology, Celbiologie

المصدر: Molecular Cell, 68(1), 210. Cell Press
Molecular Cell
Molecular Cell, 68(1), 210-223.e6. Cell Press
Molecular cell, vol 68, iss 1

مصطلحات موضوعية: 0301 basic medicine, Drug Resistance, Kinesins, Medical and Health Sciences, Microtubules, Tubulin, 2.1 Biological and endogenous factors, RNA, Guide, Sulfones, Kinetoplastida, Aetiology, Cancer, Genetics, Gene knockdown, rigosertib, Rigosertib, Kinesin, Biological Sciences, drug mechanism of action, Tubulin Modulators, 3. Good health, Gene Expression Regulation, Neoplastic, chemical genetics, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Chemical genetics, RNA, Guide, Kinetoplastida, Biotechnology, Recombinant Fusion Proteins, Genetic Vectors, Glycine, Antineoplastic Agents, Computational biology, Biology, Vinblastine, Article, Small Molecule Libraries, microtubules, 03 medical and health sciences, CRISPRa, Rare Diseases, Microtubule, Journal Article, Humans, Genetic Testing, Molecular Biology, drug target identification, Neoplastic, Human Genome, Lentivirus, CRISPRi, Cell Biology, genome-wide CRISPR screening, Orphan Drug, 030104 developmental biology, Gene Expression Regulation, Drug Resistance, Neoplasm, Myelodysplastic Syndromes, Mutation, biology.protein, Neoplasm, RNA, CRISPR-Cas Systems, Colchicine, K562 Cells, Guide, Developmental Biology, HeLa Cells, Genetic screen

وصف الملف: image/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f179af91573489aafc58613822af4048Test

المؤلفون: Paola Marzullo, Maurizio Sironi, Daniel Lucena-Agell, J. Fernando Díaz, Daniele Passarella, Helena Pérez-Peña, Zlata Boiarska, Stefano Pieraccini, Beatriz Álvarez-Bernad, Anne-Catherine Abel, Karl-Heinz Altmann, Andrea E. Prota, Francesca Vasile

المساهمون: European Commission, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), Fundación Tatiana Pérez de Guzmán el Bueno, Università degli Studi di Milano, Marzullo, Paola, Boiarska, Zlata, Abel, Anne-Catherine, Álvarez-Bernad, Beatriz, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl-Heinz, Prota, Andrea E., Díaz, José Fernando, Pieraccini, Stefano, Passarella, D., Marzullo, Paola [0000-0003-4249-8794], Boiarska, Zlata [0000-0003-1235-5717], Abel, Anne-Catherine [0000-0002-2392-9029], Álvarez-Bernad, Beatriz [0000-0002-2492-9215], Lucena-Agell, Daniel [0000-0001-7198-2900], Vasile, Francesca [0000-0002-3926-8261], Sironi, Maurizio [0000-0001-5822-4849], Altmann, Karl-Heinz [0000-0002-0747-9734], Prota, Andrea E. [0000-0003-0875-5339], Díaz, José Fernando [0000-0003-2743-3319], Pieraccini, Stefano [0000-0002-7672-0720], Passarella, D. [0000-0001-6180-9581]

المصدر: Chemistry – A European Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 28 (2)

مصطلحات موضوعية: maytansine binding site, Cancer therapy, 01 natural sciences, Catalysis, microtubules, Acylation, 03 medical and health sciences, Maytansinol, Microtubule, Neoplasms, Humans, Molecule, Maytansine, 030304 developmental biology, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Chemistry, maytansinol, tubulin, tubulin binders, Combinatorial chemistry, Tubulin Modulators, 0104 chemical sciences, 3. Good health, Tubulin, Docking (molecular), biology.protein

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3462138c4725ef6c10a3c34703000338Test
http://hdl.handle.net/10261/257058Test

المؤلفون: María A. Oliva, Susan Matthew, Ranjala Ratnayake, Hendrik Luesch, Francesca Bonato, April L. Risinger, Andrea E. Prota, Daniel Lucena-Agell, Seok Ting Lim, Qi-Yin Chen, J. Fernando Díaz, Charles S. Fermaintt, Xiaomeng Wang, Valerie J. Paul

المساهمون: National Cancer Institute (US), National Institute of General Medical Sciences (US), University of Florida, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Matthew, S. [0000-0003-4943-4777], Chen, Qi-Yin [0000-0002-4364-1057], Ratnayake, R. [0000-0002-5980-2070], Fermaintt, Charles S. [0000-0001-8140-5461], Lucena-Agell, Daniel [0000-0001-7198-2900], Bonato, Francesca [0000-0002-0579-2874], Prota, Andrea E. [0000-0003-0875-5339], Lim, Seok Ting [0000-0002-5173-5715], Wang, Xiaomeng [0000-0002-1036-2764], Díaz, José Fernando [0000-0003-2743-3319], Risinger, April L. [0000-0002-4363-3268], Paul, Valerie J. [0000-0002-4691-1569], Oliva, María A. [0000-0002-2215-4639], Luesch, H. [0000-0002-4091-7492], Matthew, S., Chen, Qi-Yin, Ratnayake, R., Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, José Fernando, Risinger, April L., Paul, Valerie J., Oliva, María A., Luesch, H.

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Proc Natl Acad Sci U S A

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Marine natural product, Antineoplastic Agents, Apoptosis, Total synthesis, Crystallography, X-Ray, Cyanobacteria, 01 natural sciences, Pentapeptide repeat, Microtubules, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Microtubule, Tubulin, Cell Line, Tumor, Depsipeptides, Drug Discovery, Humans, Maytansine, Protein Interaction Domains and Motifs, Binding site, Vinca Alkaloids, 030304 developmental biology, 0303 health sciences, Biological Products, Multidisciplinary, Natural product, Binding Sites, biology, Chemotype, 010405 organic chemistry, Biological Sciences, HCT116 Cells, In vitro, Tubulin Modulators, 3. Good health, 0104 chemical sciences, chemistry, Biochemistry, Pyrones, biology.protein, Protein Conformation, beta-Strand, Taxoids, Colchicine, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c3e59a13700d6bc432e5889d60967dTest
http://hdl.handle.net/10261/235164Test

المؤلفون: Jesús Jiménez-Barbero, Ángeles Canales, Katja Bargsten, María A. Oliva, Michel O. Steinmetz, Andrea E. Prota, Javier Rodríguez-Salarichs, J. Fernando Díaz, Youssef L. Bennani

المساهمون: Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Swiss National Science Foundation, European Commission, Club Escola Hungaresa de Esgrima de Pontevedra, Oliva, María A. [0000-0002-2215-4639], Prota, Andrea E. [0000-0003-0875-5339], Rodríguez-Salarichs, Javier [0000-0002-2932-0142], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Canales, Ángeles [0000-0003-0542-3080], Steinmetz, Michel O. [0000-0001-6157-3687], Díaz, José Fernando [0000-0003-2743-3319], Oliva, María A., Prota, Andrea E., Rodríguez-Salarichs, Javier, Jiménez-Barbero, Jesús, Canales, Ángeles, Steinmetz, Michel O., Díaz, José Fernando

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Steric effects, Noscapine, Antineoplastic Agents, macromolecular substances, Crystallography, X-Ray, 01 natural sciences, Microtubules, Anticancer drugs, Tubulin binding, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Tubulin, Drug Discovery, medicine, Animals, Humans, Colchicine, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Binding Sites, biology, Alkaloid, Tubulin Modulators, 0104 chemical sciences, 3. Good health, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, biology.protein, Biophysics, Molecular Medicine, Protein Binding, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375912e026ffea237e1cb8998d7254fTest
http://hdl.handle.net/10261/216841Test

المؤلفون: Isabel Barasoain, Nathalia Moreno Cury, José Andrés Yunes, Andrea E. Prota, Dongxiao Sun, Chunhua Song, Priscila Pini Zenatti, Tobias Mühlethaler, Sinisa Dovat, Angelo Brunelli Albertoni Laranjeira, Daniel Lucena-Agell, Rosendo A. Yunes, Michel O. Steinmetz, Rafael Renatino Canevarolo, José Fernando Díaz

المساهمون: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, University of Pennsylvania, Cury, Nathália Moreno [0000-0002-1749-812X], Zenatti, Priscila Pini [0000-0002-8662-7458], Lucena-Agell, Daniel [0000-0001-7198-2900], Barasoain, Isabel [0000-0003-2013-085X], Song, Chunhua [0000-0001-7563-0339], Dovat, Sinisa [0000-0003-3906-6165], Yunes, Rosendo Augusto [0000-0002-4529-5733], Prota, Andrea E. [0000-0003-0875-5339], Steinmetz, Michel O. [0000-0001-6157-3687], Díaz, José Fernando [0000-0003-2743-3319], Cury, Nathália Moreno, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea E., Steinmetz, Michel O., Díaz, José Fernando

المصدر: iScience
iScience, Vol 21, Iss, Pp 95-109 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, ATP-binding cassette transporter, 02 engineering and technology, macromolecular substances, Pharmacology, Article, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, medicine, Colchicine, lcsh:Science, Molecular Biology, Cancer, Multidisciplinary, biology, Therapeutic effect, Drugs, Cell cycle, Biological Sciences, 021001 nanoscience & nanotechnology, medicine.disease, 3. Good health, Multiple drug resistance, Biological sciences, 030104 developmental biology, Tubulin, chemistry, Mechanism of action, biology.protein, lcsh:Q, medicine.symptom, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0bb83c0d7ffcebf6ee1c2439a6bd23Test
https://pubmed.ncbi.nlm.nih.gov/31655259Test

المؤلفون: Michel O. Steinmetz, Amos B. Smith, Ian Paterson, Katja Bargsten, Chia Ping H. Yang, Andrea E. Prota, Mariano Redondo-Horcajo, Hayley M. McDaid, José Fernando Díaz, Susan Band Horwitz

المساهمون: Ministerio de Economía y Competitividad (España), National Cancer Institute (US), Breast Cancer Research Foundation, Swiss National Science Foundation, Prota, Andrea E. [0000-0003-0875-5339], Redondo-Horcajo, Mariano [0000-0002-9329-4786], Horwitz, Susan [0000-0002-2392-1211], Díaz, José Fernando [0000-0003-2743-3319], Steinmetz, Michel O. [0000-0001-6157-3687], Prota, Andrea E., Redondo-Horcajo, Mariano, Horwitz, Susan, Díaz, José Fernando, Steinmetz, Michel O.

المصدر: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, Bridged-Ring Compounds, Stereochemistry, Context (language use), Crystallography, X-Ray, 01 natural sciences, Biochemistry, Microtubules, Article, 03 medical and health sciences, chemistry.chemical_compound, Lactones, Microtubule, Tubulin, Alkanes, Humans, Binding site, Molecular mechanism of action, Molecular Biology, X-ray crystallography, Binding Sites, biology, 010405 organic chemistry, Tubulin Modulators, Drug discovery, Structure elucidation, Organic Chemistry, Discodermolide, 0104 chemical sciences, 3. Good health, 030104 developmental biology, chemistry, Paclitaxel, Pyrones, biology.protein, Molecular Medicine, Taxoids, Carbamates

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63e1967db3081293a6bd58faf960c41Test
http://hdl.handle.net/10261/243916Test

المؤلفون: Grégory Menchon, Lucia Altucci, Giulia Chemi, Simone Brogi, Michel O. Steinmetz, Angela Nebbioso, Natacha Olieric, Daniela M. Zisterer, Francisco de Asís Balaguer, Stefania Butini, Rebecca Amet, Cristina Ulivieri, Alessandro Grillo, Jeff O'Sullivan, Isabel Barasoain, Margherita Brindisi, J. Fernando Díaz, Ettore Novellino, Roberta Spaccapelo, Daniel Lucena-Agell, Ludovica Lopresti, Andrea E. Prota, Sandra Gemma, Mariarosaria Conte, Stefania Magnano, Cosima T. Baldari, Gloria Alfano, Giuseppe Campiani, Paula Kinsella, Tuhina Khan, Lucia Morbidelli, Ola Ibrahim

المساهمون: Brindisi, M, Ulivieri, C, Alfano, G, Gemma, S, de Asís Balaguer, F, Khan, T, Grillo, A, Chemi, G, Menchon, G, Prota, Ae, Olieric, N, Lucena-Agell, D, Barasoain, I, Diaz, Jf, Nebbioso, A, Conte, M, Lopresti, L, Magnano, S, Amet, R, Kinsella, P, Zisterer, Dm, Ibrahim, O, O'Sullivan, J, Morbidelli, L, Spaccapelo, R, Baldari, C, Butini, S, Novellino, E, Campiani, G, Altucci, L, Steinmetz, Mo, Brogi, S., Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), European Commission, Ministero dell'Istruzione, dell'Università e della Ricerca, Brindisi, Margherita, Ulivieri, Cristina, Alfano, Gloria, Gemma, Sandra, de Asís Balaguer, Francisco, Khan, Tuhina, Grillo, Alessandro, Chemi, Giulia, Menchon, Grégory, Prota, Andrea E, Olieric, Natacha, Lucena-Agell, Daniel, Barasoain, Isabel, Diaz, J Fernando, Nebbioso, Angela, Conte, Mariarosaria, Lopresti, Ludovica, Magnano, Stefania, Amet, Rebecca, Kinsella, Paula, Zisterer, Daniela M, Ibrahim, Ola, O'Sullivan, Jeff, Morbidelli, Lucia, Spaccapelo, Roberta, Baldari, Cosima, Butini, Stefania, Novellino, Ettore, Campiani, Giuseppe, Altucci, Lucia, Steinmetz, Michel O

المصدر: European Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Antitumor agents, Apoptosis, Microtubule-targeting agent, Molecular modeling, Tubulin, X-ray crystallography, Antineoplastic Agents, Cell Cycle, Cell Differentiation, Cell Line, Tumor, Drug Resistance, Multiple, Drug Screening Assays, Antitumor, Humans, Microtubules, Molecular Structure, Oxazepines, Structure-Activity Relationship, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Cellular differentiation, Drug Resistance, Drug Screening Assays, 01 natural sciences, Cancer, epigenetics, Drug Discovery, 0303 health sciences, Tumor, Chemistry, General Medicine, Cell cycle, 3. Good health, medicine.symptom, Multiple, Computational biology, Cell Line, 03 medical and health sciences, medicine, Structure–activity relationship, Mode of action, 030304 developmental biology, 010405 organic chemistry, Antitumor agent, Apoptosi, Antitumor, 0104 chemical sciences, Multiple drug resistance, Mechanism of action, Cell culture, Cancer cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac07af3e053396026a7fa9fca0f7aa6Test
http://hdl.handle.net/11391/1447652Test