Fondaparinux for the treatment of superficial-vein thrombosis in the legs
| العنوان: | Fondaparinux for the treatment of superficial-vein thrombosis in the legs |
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| المؤلفون: | Decousus, Hervé, Prandoni, Paolo, Mismetti, Patrick, Bauersachs, Rupert M, Boda, Zoltán, Brenner, Benjamin, Laporte, Silvy, Matyas, Lajos, Middeldorp, Saskia, Sokurenko, German, Leizorovicz, Alain, Bressollette, Luc |
| المساهمون: | Groupe de recherche sur la thrombose (GRT (EA 3065)), Université Jean Monnet [Saint-Étienne] (UJM), Thromboembolism Unit (PP), Universita degli Studi di Padova, Klinikum Darmstadt (RMB), Klinikum Darmstadt, Department of Medicine (DEBRECEN - Dpt Medicine), University of Debrecen, Thrombosis and Haemostasis Unit, Technion - Israel Institute of Technology [Haifa], Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Saint Etienne, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Vascular and Endovascular Surgery (DVES), University Teaching Hospital Miskolc, Departments of Clinical Epidemiology and General Internal Medicine (DCEGIM), Leiden University Medical Center (LUMC), City Hospital, City Hospital St Petersburg, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Other departments, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine |
| المصدر: | New England Journal of Medicine New England Journal of Medicine, Massachusetts Medical Society, 2010, 363 (13), pp.1222-32. ⟨10.1056/NEJMoa0912072⟩ Europe PubMed Central New England Journal of Medicine, Massachusetts Medical Society, 2010, 363(13), pp.1222-1232 New England Journal of Medicine, 2010, 363 (13), pp.1222-1232. ⟨10.1056/NEJMoa0912072⟩ New England Journal of Medicine, 363(13), 1222-1232 New England journal of medicine, 363(13), 1222-1232. Massachussetts Medical Society |
| بيانات النشر: | HAL CCSD, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Relative risk reduction, Male, MESH: Pulmonary Embolism, Superficial vein thrombosis, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Fondaparinux, 0302 clinical medicine, Recurrence, Medicine, MESH: Double-Blind Method, 030212 general & internal medicine, MESH: Treatment Outcome, Venous Thrombosis, MESH: Risk, MESH: Middle Aged, Anticoagulant, General Medicine, Orvostudományok, molecular-weight heparin randomized double-blind venous thromboembolism risk-factors medical patients thrombophlebitis metaanalysis prevention surgery prophylaxis, Middle Aged, Thrombosis, 3. Good health, Pulmonary embolism, Treatment Outcome, Anesthesia, Acute Disease, MESH: Acute Disease, Female, MESH: Hemorrhage, medicine.drug, Risk, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.drug_class, Hemorrhage, MESH: Anticoagulants, Placebo, Klinikai orvostudományok, 03 medical and health sciences, Double-Blind Method, Polysaccharides, Humans, MESH: Kaplan-Meier Estimate, MESH: Humans, business.industry, Anticoagulants, medicine.disease, Fondaparinux Sodium, MESH: Male, MESH: Recurrence, MESH: Polysaccharides, MESH: Venous Thrombosis, business, Pulmonary Embolism, MESH: Female |
| الوصف: | International audience; BACKGROUND: The efficacy and safety of anticoagulant treatment for patients with acute, symptomatic superficial-vein thrombosis in the legs, but without concomitant deep-vein thrombosis or symptomatic pulmonary embolism at presentation, have not been established. METHODS: In a randomized, double-blind trial, we assigned 3002 patients to receive either fondaparinux, administered subcutaneously at a dose of 2.5 mg once daily, or placebo for 45 days. The primary efficacy outcome was a composite of death from any cause or symptomatic pulmonary embolism, symptomatic deep-vein thrombosis, or symptomatic extension to the saphenofemoral junction or symptomatic recurrence of superficial-vein thrombosis at day 47. The main safety outcome was major bleeding. The patients were followed until day 77. RESULTS: The primary efficacy outcome occurred in 13 of 1502 patients (0.9%) in the fondaparinux group and 88 of 1500 patients (5.9%) in the placebo group (relative risk reduction with fondaparinux, 85%; 95% confidence interval [CI], 74 to 92; P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0028-4793 1533-4406 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3d4f9fba51b5afba504e7e53d645f2Test https://hal.univ-brest.fr/hal-00927770Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e3d4f9fba51b5afba504e7e53d645f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00284793 15334406 |
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