Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial
| العنوان: | Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial |
|---|---|
| المؤلفون: | Issiaka Soulama, Oumar B Traore, Désiré Kargougou, Malick Minkael Sylla, Hamadoun Diakite, Anders Björkman, San Maurice Ouattara, Boubou Sangare, Edith C Bougouma, Amidou Diarra, Harouna Soré, Frederic Nikiema, Sodiomon B. Sirima, Aissata Barry, Aboubacar S Coulibaly, Niawanlou Dara, Abdoul Habib Beavogui, Stéphane Picot, Anyirékun Fabrice Somé, Stephan Duparc, Abdoulaye Djimde, Steffen Borrmann, Ogobara K. Doumbo, Robert M Miller, Amadou H Togo, Samba Coumare, Noelie Henry, Bouran Sidibe, Issaka Sagara, Siaka Goita, Jean-Bosco Ouédraogo, Moise Kabore, Hamma Maiga, Issaka Zongo, José Pedro Gil, Mamadou Saliou Diallo, Jangsik Shin, Mohamed Lamine Alhousseini, Moctar Coulibaly, Bakary Fofana, Hamidou Niangaly, Moussa Djimde, Alassane Dicko, Colin J. Sutherland, Nouhoum Diallo, Isabelle Borghini-Fuhrer, Daouda Camara, Mohamed Keita, Yves D Compaore, Sekou Koumare, Modibo Diarra, Aliou Traore, Souleymane Dama, Amadou Bamadio, Ismaila Thera, Francois Dao |
| المساهمون: | Department of Epidemiology of Parasitic Diseases, Université de Bamako-Malaria Research and Training Centre, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] (CNRFP), University of Science, Techniques, and Technologies [Bamako, Mali], Université Bordeaux Segalen - Bordeaux 2, Département de mathématiques, Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), Malaria Research and Training Center [Bamako, Mali], Université de Bamako, Département d'Epidémiologie des Affections parasitaires, Malaria Research and training center Université de Bamako, Mali, Malaria Research and Training Center (MRTC), Faculté de Médecine de Bamako, London School of Hygiene and Tropical Medicine (LSHTM), Radicaux Libres, Substrats Énergétiques et Physiopathologie Cérébrale, Université de Lyon-Université de Lyon, German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), Royal Free and University College Medical School, Uppsala University, Karolinska Institutet [Stockholm, Sweden], Institut de Recherche en Sciences de la Santé Bobo Dioulasso (INSSA), Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), Département d'épidémiologie des affections parasitaires (DEAP), Université de Bamako-Malaria Research and Training Center (MRTC)-Facultés de Médecine, de Pharmacie et d'Odonto-Stomatologie-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | The Lancet The Lancet, Elsevier, 2018, 391 (10128), pp.1378-1390. ⟨10.1016/S0140-6736(18)30291-5⟩ Lancet (London, England) |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Artesunate, Plasmodium malariae, Rate ratio, chemistry.chemical_compound, 0302 clinical medicine, Dihydroartemisinin/piperaquine, Longitudinal Studies, Child, ComputingMilieux_MISCELLANEOUS, education.field_of_study, biology, General Medicine, Plasmodium ovale, Artemisinins, 3. Good health, Drug Combinations, Ethanolamines, Child, Preschool, Quinolines, Drug Therapy, Combination, Female, medicine.medical_specialty, Adolescent, 030106 microbiology, 030231 tropical medicine, Population, Article, 03 medical and health sciences, Young Adult, Antimalarials, Internal medicine, parasitic diseases, medicine, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Naphthyridines, education, Pyronaridine, Fluorenes, business.industry, Artemether, Lumefantrine Drug Combination, Amodiaquine, medicine.disease, biology.organism_classification, Malaria, chemistry, business |
| الوصف: | Summary Background Artemether–lumefantrine and artesunate–amodiaquine are used as first-line artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine–artesunate and dihydroartemisinin–piperaquine are potentially useful for diversification of ACTs in this region, but further safety and efficacy data are required on malaria retreatment. Methods We did a randomised, multicentre, open-label, longitudinal, controlled phase 3b/4 clinical trial at seven tertiary centres in Burkina Faso, Guinea, and Mali. Eligible participants for first malaria episode and all retreatment episodes were adults and children aged 6 months and older with microscopically confirmed Plasmodium spp malaria (>0 to |
| اللغة: | English |
| تدمد: | 0923-7577 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75919a3d04b1b4cc23db33e4cac40681Test https://hal-udl.archives-ouvertes.fr/hal-02136477Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75919a3d04b1b4cc23db33e4cac40681 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237577 |
|---|