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1
المؤلفون: Carly S. Mazzone, Antonio Dominguez-Meijide, Jeffrey L. Brodsky, Mary Liang, Tiago F. Outeiro, Annette N. Chiang, David Newhouse, Peter Wipf, Nathan M. Kendsersky, Megan E. Yates, Patrick G. Needham, Caterina Masaracchia, Alexandra Manos-Turvey, Jennifer L. Goeckeler-Fried
المصدر: Bioorganic & Medicinal Chemistry. 27:79-91
مصطلحات موضوعية: Protein Folding, Clinical Biochemistry, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, Enzyme Activators, Pharmaceutical Science, Pyrimidinones, Saccharomyces cerevisiae, Protein aggregation, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Cell Line, Tumor, Cellular stress response, Drug Discovery, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, Adenosine Triphosphatases, Molecular Structure, biology, 010405 organic chemistry, Activator (genetics), Chemistry, Organic Chemistry, HEK 293 cells, Esters, Cystic fibrosis transmembrane conductance regulator, 3. Good health, 0104 chemical sciences, Hsp70, Cell biology, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Proteostasis, alpha-Synuclein, biology.protein, Molecular Medicine, Protein Multimerization
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5c63d4a71c5b638613d360a3ee103Test
https://doi.org/10.1016/j.bmc.2018.11.011Test -
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المؤلفون: Susanna Navarro, Jordi Pujols, Ernest Giralt, Samuel Peña-Díaz, Xavier Salvatella, Danilo González, Francesca Peccati, Diana F. Lázaro, Salvador Guardiola, Esther Dalfó, María Conde-Giménez, Tiago F. Outeiro, Javier Sancho, Jesús García, Mariona Sodupe, Salvador Ventura, Francisca Pinheiro, Anita Carija
المصدر: Proceedings of the National Academy of Sciences. 115:10481-10486
مصطلحات موضوعية: 0301 basic medicine, Amyloid, Parkinson's disease, Neurite, Motility, Protein aggregation, Fibril, Protein Aggregation, Pathological, Small Molecule Libraries, Neuroblastoma, 03 medical and health sciences, Tumor Cells, Cultured, medicine, Animals, Humans, Caenorhabditis elegans, Multidisciplinary, biology, Chemistry, Dopaminergic Neurons, Dopaminergic, Parkinson Disease, Biological Sciences, medicine.disease, biology.organism_classification, Small molecule, High-Throughput Screening Assays, nervous system diseases, 3. Good health, Cell biology, 030104 developmental biology, nervous system, alpha-Synuclein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1db49e4743fa279af6e4ffc3a895f6Test
https://doi.org/10.1073/pnas.1804198115Test -
3
المصدر: Biochimica et biophysica acta / Proteins and proteomics 1869(10), 140693 (2021). doi:10.1016/j.bbapap.2021.140693
Biochimica et Biophysica Acta. Proteins and Proteomicsمصطلحات موضوعية: Proteome, metabolism [Viral Proteins], Bioinformatics, In silico, viruses, Biophysics, Plasma protein binding, Disease, Protein aggregation, Biology, medicine.disease_cause, APR, aggregation-prone regions, Virus Replication, Biochemistry, pathogenicity [SARS-CoV-2], Analytical Chemistry, CoVex, Coronavirus Explorer, metabolism [SARS-CoV-2], 03 medical and health sciences, Open Reading Frames, Viral Proteins, 0302 clinical medicine, ORF, open reading frame, PDB, Protein Data Bank, ddc:570, medicine, Molecular Biology, 030304 developmental biology, Coronavirus, Genetics, 0303 health sciences, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, PASTA, prediction of amyloid structural aggregation, SARS-CoV-2, genetics [SARS-CoV-2], Entry into host, 3. Good health, Proteostasis, Mutation, NSP, non-structural proteins, A3D, Aggrescan3D, 030217 neurology & neurosurgery, COVID-19, coronavirus disease 19, Research Paper, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5e3302f41d3ee8b3a2526f7302e165Test
https://pub.dzne.de/record/155650Test -
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المؤلفون: Markus Zweckstetter, Tiago F. Outeiro, Annekatrin König, Antonio Dominguez-Meijide, Alain Ibáñez de Opakua, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Maria-Sol Cima-Omori, Eftychia Vasili
المصدر: Scientific Reports
Scientific reports 10(1), 12827 (2020). doi:10.1038/s41598-020-69744-y
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, Protein aggregation, therapeutic use [Benzodioxoles], Catechin, 0302 clinical medicine, drug therapy [Alzheimer Disease], therapeutic use [Catechin], metabolism [alpha-Synuclein], Molecular Targeted Therapy, Internalization, lcsh:Science, Cells, Cultured, media_common, pharmacology [Benzopyrans], Multidisciplinary, biology, Chemistry, analogs & derivatives [Catechin], Brain, Neurofibrillary Tangles, Parkinson Disease, 3. Good health, Pharmacological interventions, metabolism [Neurofibrillary Tangles], therapeutic use [Pyrazoles], alpha-Synuclein, pharmacology [Catechin], metabolism [Alzheimer Disease], therapeutic use [Hydrazones], Cell biology, Tau pathology, media_common.quotation_subject, Tau protein, metabolism [Parkinson Disease], pharmacology [Benzodioxoles], tau Proteins, Protein Aggregation, Pathological, Article, pharmacology [Hydrazones], 03 medical and health sciences, Protein Aggregates, metabolism [Protein Aggregation, Pathological], Alzheimer Disease, medicine, Dementia, Humans, Benzopyrans, Benzodioxoles, therapeutic use [Benzopyrans], Lewy body, lcsh:R, Hydrazones, drug effects [Protein Aggregates], medicine.disease, metabolism [Lewy Bodies], drug therapy [Parkinson Disease], metabolism [tau Proteins], 030104 developmental biology, metabolism [Brain], biology.protein, Pyrazoles, α synuclein, lcsh:Q, Lewy Bodies, pharmacology [Pyrazoles], Neuroscience, ddc:600, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903b3e0459c4302fe89a41ea5e55c9f5Test
https://hdl.handle.net/21.11116/0000-0008-7D9B-E21.11116/0000-0008-7D97-2Test -
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المؤلفون: Nicolás A. Rey, Tiago F. Outeiro, Renata Diniz, Patrícia R Ferreira, Claudio O. Fernández, Pamela Sacco, Diana F. Lázaro, Daphne S Cukierman
المصدر: Dalton transactions (Cambridge, England : 2003). 49(45)
مصطلحات موضوعية: Synucleinopathies, chemistry.chemical_element, Protein aggregation, medicine.disease_cause, Ligands, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Protein Aggregates, 0302 clinical medicine, medicine, Humans, 030304 developmental biology, 0303 health sciences, Neurodegeneration, Hydrazones, Bioinorganic chemistry, medicine.disease, Ligand (biochemistry), Copper, In vitro, 3. Good health, chemistry, Drug Design, Biophysics, alpha-Synuclein, Cellular model, 030217 neurology & neurosurgery, Oxidative stress, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d33e800a58d6f0f8659e01dcb7279fTest
https://pubmed.ncbi.nlm.nih.gov/32391542Test -
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المؤلفون: A. Koenig, Armin Giese, Sergey Ryazanov, Andrei Leonov, Antonio Dominguez-Meijide, Eftychia Vasili, Tiago F. Outeiro, Christian Griesinger, Markus Zweckstetter, Maria-Sol Cima-Omori
مصطلحات موضوعية: 0303 health sciences, Tau pathology, Lewy body, biology, Chemistry, media_common.quotation_subject, Tau protein, Protein aggregation, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Pharmacological interventions, medicine, biology.protein, Dementia, α synuclein, Internalization, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552bee05b7adb28ecff62f8958c8bc31Test
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المؤلفون: Maria Angeliki S. Pavlou, Diana F. Lázaro, Tiago F. Outeiro
المصدر: Experimental Neurology. 298:162-171
مصطلحات موضوعية: 0301 basic medicine, Nervous system, Parkinson's disease, Population, Drug Evaluation, Preclinical, Disease, Protein aggregation, Biology, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Developmental Neuroscience, medicine, Animals, Humans, education, Alpha-synuclein, education.field_of_study, Neurodegeneration, Parkinson Disease, medicine.disease, Phenotype, 3. Good health, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Neurology, chemistry, alpha-Synuclein, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39892a08689ade63d19d1bfc8512f0acTest
https://doi.org/10.1016/j.expneurol.2017.05.007Test -
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المؤلفون: Nishant N. Vaikath, Jia-Yi Li, Zhan-You Wang, Jia-Zhen Wu, Omar M. A. El-Agnaf, Tiago F. Outeiro, Caroline Haikal, Wen Li, Mustafa T. Ardah, Alexander Svanbergsson, Meike Diepenbroek
المصدر: Translational Neurodegeneration
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-15 (2019)
Translational neurodegenerationمصطلحات موضوعية: 0301 basic medicine, alpha-synuclein, Cognitive Neuroscience, Protein degradation, Protein aggregation, lcsh:RC346-429, protein aggregation, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Chaperone-mediated autophagy, In vivo, chaperone-mediated autophagy, Cytotoxicity, lcsh:Neurology. Diseases of the nervous system, Chemistry, Research, lysosomal-associated membrane protein, Autophagy, Transfection, 3. Good health, Cell biology, nervous system diseases, Parkinson disease, macroautophagy, 030104 developmental biology, nervous system, Neurology (clinical), 030217 neurology & neurosurgery, Intracellular
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1458e39da7294930c7331b67b91cefTest
http://resolver.sub.uni-goettingen.de/purl?gs-1/16196Test -
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المؤلفون: Guowei Yin, Karin Giller, Markus Zweckstetter, Tiago F. Outeiro, Timo Strohäker, Francesca Munari, Joshua Salafsky, Ben Moree, Diana F. Lázaro, Stefan Becker
المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry
The journal of biological chemistry 290(46), 27582-27593 (2015). doi:10.1074/jbc.M114.636027مصطلحات موضوعية: Protein Conformation, animal diseases, pharmacology [Small Molecule Libraries], Protein aggregation, Ligands, Biochemistry, Antiparkinson Agents, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, Neurons, 0303 health sciences, Tumor, Drug discovery, Parkinson Disease, Small molecule, 3. Good health, metabolism [Neurons], ddc:540, chemistry [Antiparkinson Agents], alpha-Synuclein, Parkinson disease, drug discovery, protein aggregation, protein conformation, protein drug interaction, Cell Line, Tumor, Humans, Protein Aggregates, Protein Aggregation, Pathological, Small Molecule Libraries, isolation & purification [Small Molecule Libraries], Molecular Biophysics, chemistry [Small Molecule Libraries], metabolism [Parkinson Disease], Cell Line, 03 medical and health sciences, metabolism [Protein Aggregation, Pathological], Pathological, mental disorders, Molecular Biology, 030304 developmental biology, Alpha-synuclein, pharmacology [Antiparkinson Agents], drug therapy [Protein Aggregation, Pathological], Binding protein, drug effects [Protein Aggregates], Cell Biology, Protein Aggregation, drug therapy [Parkinson Disease], isolation & purification [Antiparkinson Agents], nervous system diseases, drug effects [Protein Conformation], chemistry [alpha-Synuclein], nervous system, chemistry, Biophysics, 030217 neurology & neurosurgery, Protein ligand
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94d4e41f529440ed17d7b805a1a18abTest
https://doi.org/10.1074/jbc.m114.636027Test -
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المؤلفون: Patrícia Guerreiro, Susana Gonçalves, Salvador Ventura, Evangelia Emmanouilidou, Anna Villar-Piqué, Tiago Antônio de Oliveira Mendes, Flaviano Giorgini, Duarte C. Barral, Tiago F. Outeiro, Zrinka Marijanovic, Oldriska Chutna, Kostas Vekrellis, José S. Ramalho, Jochen Klucken
المصدر: Human Molecular Genetics. 23:6732-6745
مصطلحات موضوعية: Recombinant Fusion Proteins, Endocytic cycle, Biology, Protein aggregation, Exosomes, Transfection, Protein Aggregates, chemistry.chemical_compound, Cell Line, Tumor, Genetics, Humans, Small GTPase, Secretion, RNA, Small Interfering, Molecular Biology, Genetics (clinical), Inclusion Bodies, Neurons, Alpha-synuclein, Synucleinopathies, Biological Transport, General Medicine, 3. Good health, Cell biology, Gene Expression Regulation, chemistry, rab GTP-Binding Proteins, alpha-Synuclein, Signal transduction, Intracellular, Plasmids, Protein Binding, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09d3fc061845d548e7717940d3d2750Test
https://doi.org/10.1093/hmg/ddu391Test
