Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extended-spectrum-β-lactamase-producing Enterobacteriaceae
| العنوان: | Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extended-spectrum-β-lactamase-producing Enterobacteriaceae |
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| المؤلفون: | Mitchell J. Schwaber, Jesús Rodríguez-Baño, David L. Paterson, Pierluigi Viale, Belén Gutiérrez-Gutiérrez, Julián Torre-Cisneros, Axel Hamprecht, Núria Prim, Helen Giamarellou, Federico Perez, Alicia Hernandez-Torres, Marina de Cueto, Mario Tumbarello, Mario Venditti, Luis Martínez-Martínez, Evelina Tacconelli, José Antonio Lepe, Po-Ren Hsueh, Manuel Almela, Carolina Navarro-San Francisco, Warren Lowman, Antonio Oliver, Germán Bou, Oriol Gasch, Johann D. D. Pitout, Vicente Pintado, Zaira R. Palacios-Baena, Julia Origüen, Carmen Peña-Miralles, Benito Almirante, Murat Akova, Robert A. Bonomo, Álvaro Pascual, Yehuda Carmeli, Joaquín Bermejo, Esther Calbo |
| المساهمون: | Ministerio de Economía y Competitividad (España), European Commission, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Federation of Pharmaceutical Industries and Associations, Cuyahoga County Veterans Service Commission, Geriatric Research Education and Clinical Center (US), National Institute of Allergy and Infectious Diseases (US), İç Hastalıkları, Palacios-Baena, Zaira Raquel, Gutiérrez-Gutiérrez, Belén, De Cueto, Marina, Viale, Pierluigi, Venditti, Mario, Hernández-Torres, Alicia, Oliver, Antonio, Martínez-Martínez, Lui, Calbo, Esther, Pintado, Vicente, Gasch, Oriol, Almirante, Benito, Antonio Lepe, José, Pitout, Johann, Akova, Murat, Peña-Miralles, Carmen, Schwaber, Mitchell J., Tumbarello, Mario, Tacconelli, Evelina, Origüen, Julia, Prim, Nuria, Bou, German, Giamarellou, Helen, Bermejo, Joaquín, Hamprecht, Axel, Pérez, Federico, Almela, Manuel, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Torre-Cisneros, Julián, Carmeli, Yehuda, Bonomo, Robert A., Paterson, David L., Pascual, Álvaro, Rodríguez-Baño, Jesús |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Instituto de Salud Carlos III (ISCIII) |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Predictive Value of Test, Bacteremia, Logistic regression, beta-Lactamase, 0302 clinical medicine, Retrospective Studie, Klebsiella, Risk of mortality, polycyclic compounds, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Original Research, Framingham Risk Score, Mortality rate, Enterobacteriaceae Infections, Middle Aged, Prognosis, 3. Good health, Anti-Bacterial Agents, Infectious Diseases, Predictive value of tests, Female, Human, Microbiology (medical), medicine.medical_specialty, Logistic Model, Prognosi, Sepsi, 030106 microbiology, Microbiology, beta-Lactamases, 03 medical and health sciences, Enterobacteriaceae, Predictive Value of Tests, Internal medicine, Sepsis, Anti-Bacterial Agent, medicine, Humans, Aged, Klebsiella Infections, Logistic Models, Retrospective Studies, Pharmacology, Receiver operating characteristic, business.industry, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, medicine.disease, bacterial infections and mycoses, Enterobacteriaceae Infection, Surgery, bacteria, business, Klebsiella Infection |
| الوصف: | [Background] Bloodstream infections (BSIs) due to ESBL-producing Enterobacteriaceae (ESBL-E) are frequent yet outcome prediction rules for clinical use have not been developed. The objective was to define and validate a predictive risk score for 30 day mortality. [Methods] A multinational retrospective cohort study including consecutive episodes of BSI due to ESBL-E was performed; cases were randomly assigned to a derivation cohort (DC) or a validation cohort (VC). The main outcome variable was all-cause 30 day mortality. A predictive score was developed using logistic regression coefficients for the DC, then tested in the VC. [Results] The DC and VC included 622 and 328 episodes, respectively. The final multivariate logistic regression model for mortality in the DC included age >50 years (OR = 2.63; 95% CI: 1.18–5.85; 3 points), infection due to Klebsiella spp. (OR = 2.08; 95% CI: 1.21–3.58; 2 points), source other than urinary tract (OR = 3.6; 95% CI: 2.02–6.44; 3 points), fatal underlying disease (OR = 3.91; 95% CI: 2.24–6.80; 4 points), Pitt score >3 (OR = 3.04; 95 CI: 1.69–5.47; 3 points), severe sepsis or septic shock at presentation (OR = 4.8; 95% CI: 2.72–8.46; 4 points) and inappropriate early targeted therapy (OR = 2.47; 95% CI: 1.58–4.63; 2 points). The score showed an area under the receiver operating curve (AUROC) of 0.85 in the DC and 0.82 in the VC. Mortality rates for patients with scores of [Conclusions] We developed and validated an easy-to-collect predictive scoring model for all-cause 30 day mortality useful for identifying patients at high and low risk of mortality. This study was funded by: the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III co-financed by the European Development Regional Fund ‘A way to achieve Europe’ ERDF, the Spanish Network for Research in Infectious Diseases (REIPI RD12/0015), FIS grant PI10/02021 and FIS grant PI14/01832. B. G. G., J. R. B., A. P. and Y. C. also received funds from the COMBACTE-CARE project, Innovative Medicines Initiative (IMI), the European Union’s Seventh Framework Programme (FP7/2007-2013) and in-kind contributions from EFPIA companies. R. A. B. was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs, the Veterans Affairs Merit Review Program and the Geriatric Research Education and Clinical Center VISN 10 (VISN 10 GRECC), and the NIAID of the NIH under award numbers R01AI072219 and R01AI063517. |
| وصف الملف: | application/pdf; text/plain; STAMPA |
| تدمد: | 0305-7453 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b24ab96930711605cbfa5acaccd67bTest http://hdl.handle.net/10261/191691Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51b24ab96930711605cbfa5acaccd67b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03057453 |
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