The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
| العنوان: | The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer |
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| المؤلفون: | Veronica Chanes, Clara Suñer, Raúl Méndez, Yi-Shuian Huang, Rosa Pascual, Oscar Reina, Gonzalo Fernández-Miranda, Anna Bartomeu, Alba Millanes-Romero, Fernando Salvador, Judit Martin, Roger R. Gomis |
| المصدر: | Science Advances |
| بيانات النشر: | American Association for the Advancement of Science, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Polyadenylation, Organogenesis, RNA-binding protein, Breast Neoplasms, CPEB, 03 medical and health sciences, 0302 clinical medicine, Gene expression, Protein biosynthesis, Humans, RNA, Messenger, Mammary Glands, Human, Transcription factor, Molecular Biology, 3' Untranslated Regions, Research Articles, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Multidisciplinary, biology, RNA, SciAdv r-articles, RNA-Binding Proteins, Cell Biology, Hormones, Cell biology, 030220 oncology & carcinogenesis, biology.protein, Female, Research Article |
| الوصف: | The RNA binding protein CPEB2 defines a new posttranscriptional layer in the hormone-driven gene-expression reprogramming. Organogenesis is directed by coordinated cell proliferation and differentiation programs. The hierarchical networks of transcription factors driving mammary gland development and function have been widely studied. However, the contribution of posttranscriptional gene expression reprogramming remains largely unexplored. The 3′ untranslated regions of messenger RNAs (mRNAs) contain combinatorial ensembles of cis-regulatory elements that define transcript-specific regulation of protein synthesis through their cognate RNA binding proteins. We analyze the contribution of the RNA binding cytoplasmic polyadenylation element–binding (CPEB) protein family, which collectively regulate mRNA translation for about 30% of the genome. We find that CPEB2 is required for the integration of hormonal signaling by controlling the protein expression from a subset of ER/PR- regulated transcripts. Furthermore, CPEB2 is critical for the development of ER-positive breast tumors. This work uncovers a previously unknown gene expression regulation level in breast morphogenesis and tumorigenesis, coordinating sequential transcriptional and posttranscriptional layers of gene expression regulation. |
| اللغة: | English |
| تدمد: | 2375-2548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7865030dd729bcce51952b6f269e2de4Test http://europepmc.org/articles/PMC7228762Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7865030dd729bcce51952b6f269e2de4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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