Anatomically constrained tractography facilitates biologically plausible fiber reconstruction of the optic radiation in multiple sclerosis
| العنوان: | Anatomically constrained tractography facilitates biologically plausible fiber reconstruction of the optic radiation in multiple sclerosis |
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| المؤلفون: | Kristian Loewe, Jörn Kaufmann, Mircea Ariel Schoenfeld, M. Horbruegger, Sven Schippling, Marc Pawlitzki, M. Wagner |
| المساهمون: | University of Zurich, Pawlitzki, M |
| المصدر: | NeuroImage: Clinical, Vol 22, Iss, Pp-(2019) NeuroImage : Clinical NeuroImage: Clinical, 22:101740 NeuroImage: Clinical, 22 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Computer science, lcsh:RC346-429, 0302 clinical medicine, Internal Capsule, Image Processing, Computer-Assisted, Visual Cortex, medicine.diagnostic_test, Multiple sclerosis, Optic radiation, Probabilistic tractography, Magnetic resonance imaging, Diffusion MRI, Fiber tracking, ACT, Orientation (computer vision), 05 social sciences, Regular Article, Middle Aged, White Matter, Diffusion Tensor Imaging, medicine.anatomical_structure, 2728 Neurology (clinical), Neurology, lcsh:R858-859.7, Female, Tractography, Adult, 2805 Cognitive Neuroscience, Cognitive Neuroscience, 610 Medicine & health, Lateral geniculate nucleus, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Young Adult, 03 medical and health sciences, medicine, Humans, 2741 Radiology, Nuclear Medicine and Imaging, Visual Pathways, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, Aged, 10040 Clinic for Neurology, Diffusion Magnetic Resonance Imaging, Visual cortex, 2808 Neurology, FMRIB Software Library, Neurology (clinical), 030217 neurology & neurosurgery, Biomedical engineering |
| الوصف: | Diffusion-weighted magnetic resonance imaging (dMRI) enables the microstructural characterization and reconstruction of white matter pathways in vivo non-invasively. However, dMRI only provides information on the orientation of potential fibers but not on their anatomical plausibility. To that end, recent methodological advances facilitate the effective use of anatomical priors in the process of fiber reconstruction, thus improving the accuracy of the results. Here, we investigated the potential of anatomically constrained tracking (ACT), a modular addition to the tractography software package MRtrix3, to accurately reconstruct the optic radiation, a commonly affected pathway in multiple sclerosis (MS). Diffusion MRI data were acquired from 28 MS patients and 22 age- and sex-matched healthy controls. For each participant, the optic radiation was segmented based on the fiber reconstruction obtained using ACT. When implementing ACT in MS, it proved essential to incorporate lesion maps to avoid incorrect reconstructions due to tissue-type misclassifications in lesional areas. The ACT-based results were compared with those obtained using two commonly used probabilistic fiber tracking procedures, based on FSL (FMRIB Software Library) and MRtrix3 without ACT. All three procedures enabled a reliable localization of the optic radiation in both MS patients and controls. However, for FSL and MRtrix3 without ACT it was necessary to place an additional waypoint halfway between the lateral geniculate nucleus and the primary visual cortex to filter out anatomically implausible tracks. In the case of ACT, the results with and without an additional waypoint were virtually identical, presumably because the employed anatomical constraints already prevented the occurrence of the most implausible tracks. Irrespective of the employed tractography procedure, increased diffusivity and decreased anisotropy were found in the optic radiation of the MS patients compared to the controls. NeuroImage: Clinical, 22 ISSN:2213-1582 |
| وصف الملف: | Unbenannt.pdf - application/pdf; application/application/pdf |
| اللغة: | English |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f141cc6e8210ac4390baaed29e5bfbd7Test https://www.zora.uzh.ch/id/eprint/176676Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f141cc6e8210ac4390baaed29e5bfbd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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