دورية أكاديمية
Immunomodulatory role of microRNAs transferred by extracellular vesicles
| العنوان: | Immunomodulatory role of microRNAs transferred by extracellular vesicles |
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| المؤلفون: | Fernández Messina, Lola María, Gutiérrez‐Vázquez, Cristina, Rivas‐García, Eva, Sánchez‐Madrid, Francisco, Fuente, Hortensia de la |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 576.3, Extracellular Vesicles (EVs), Exosomes, microRNA (miRNA), immune modulation, intercellular communication, Biología celular (Biología), Bioquímica (Biología), Inmunología, 2403 Bioquímica, 2407 Biología Celular, 2412 Inmunología, 2410.03 Citología Humana |
| الوصف: | Funding This work is supported by grants SAF2011-25834, ERC-2011-ADG_20110310, Cardiovascular Network RD12-0042-0056 (Instituto de Salud Carlos III), PIE-13-00041 and INDISNET S2011-BMD-2332. L.F.M. is supported by the Juan de la Cierva grant (Spanish Ministry of Economy and Competitivity) and E.R.G. by the Spanish Ministry of Health. ; The immune system is composed of different cell types localised throughout the organism to sense and respond to pathological situations while maintaining homeostasis under physiological conditions. Intercellular communication between immune cells is essential to coordinate an effective immune response and involves both cell contact dependent and independent processes that ensure the transfer of information between bystander and distant cells. There is a rapidly growing body of evidence on the pivotal role of extracellular vesicles (EVs) in cell communication and these structures are emerging as important mediators for immune modulation upon delivery of their molecular cargo. In the last decade, EVs have been shown to be efficient carriers of genetic information, including microRNAs (miRNAs), that can be transferred between cells and regulate gene expression and function on the recipient cell. Here, we review the current knowledge of intercellular functional transfer of EV‐delivered miRNAs and their putative role in immune regulation. ; Depto. de Biología Celular ; Fac. de Ciencias Biológicas ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0248-4900 1768-322X |
| العلاقة: | info:eu-repo/grantAgreement/MICINN//SAF2011-25834/ES/NUEVOS MECANISMOS DE INMUNO-MODULACION: MOLECULAS REGULADORAS, POLARIDAD CELULAR Y TRANSFERENCIA DE INFORMACION GENETICA EN LA COMUNICACION INTERCELULAR/; ERC-2011-ADG_20110310; Cardiovascular Network RD12-0042-0056 (Instituto de Salud Carlos III); PIE-13-00041; INDISNET S2011-BMD-2332; Juan de la Cierva grant; https://hdl.handle.net/20.500.14352/97163Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010100Test/ |
| DOI: | 10.1111/boc.201400081 |
| الإتاحة: | https://doi.org/20.500.14352/97163Test https://doi.org/10.1111/boc.201400081Test https://hdl.handle.net/20.500.14352/97163Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010100Test/ |
| حقوق: | restricted access |
| رقم الانضمام: | edsbas.DDA04660 |
| قاعدة البيانات: | BASE |
| تدمد: | 02484900 1768322X |
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| DOI: | 10.1111/boc.201400081 |