Advanced nanomedicines for the treatment of inflammatory diseases
| العنوان: | Advanced nanomedicines for the treatment of inflammatory diseases |
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| المؤلفون: | Patrick Couvreur, Romain Brusini, Mariana Varna |
| المساهمون: | Institut Galien Paris-Saclay (IGPS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Advanced Drug Delivery Reviews Advanced Drug Delivery Reviews, Elsevier, 2020, 157, pp.161-178. ⟨10.1016/j.addr.2020.07.010⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], Anti-Inflammatory Agents, Pharmaceutical Science, 02 engineering and technology, Disease, Dex, Dexamethasone, Pathogenesis, TCR, T cell receptors, bFGF, basic fibroblast growth factor, Drug Delivery Systems, DC, dendritic cells, ATP, Adenosine Triphosphate, HA, Hyaluronic Acid, LMWH, Low Molecular Weight Heparin, NPs, Nanoparticles, pDNA, plasmid DeoxyriboNucleic Acid, Tissue homeostasis, COVID-19, coronavirus disease 2019, EAE, experimental autoimmune encephalomyelitis, NIPAM, N-Isopropyl acrylamide, ICAM, Inter-Cellular Adhesion Molecule, 0303 health sciences, VEGF, Vascular Endothelial Growth Factor, RA, Rheumatoid arthritis, PRR, Pattern-Recognition Receptor, VCAM, Vascular Cell Adhesion Molecule, 021001 nanoscience & nanotechnology, Clinical application, ROS, Radical Oxygen Species, 3. Good health, IBD, Inflammatory Bowel Diseases, PEG, Polyethylene Glycol, Nanomedicine, TLR, Toll-Like Receptor, APCs, antigen-presenting cells, medicine.symptom, 0210 nano-technology, 5-ASA, 5-AminoSalicylic Acid (also called Mesalazine), 2019-20 coronavirus outbreak, PSL, PhosphatidylSerine-containing Liposome, MPO, Myeloperoxidase, PEI, Polyethyleneimine, Inflammation, TNF-α, Tumor Necrosis Factor alpha, Article, NF-κB, Nuclear Factor-kappa B, Permeability, PLGA, Poly(Lactic-co-Glycolic Acid), 03 medical and health sciences, Immune system, medicine, Animals, Humans, HIF, Hypoxia-Inducible transcription Factor, LXR, Liver X Receptor, 030304 developmental biology, NSAID, Non-Steroidal Anti-inflammatory Drug, IL-10, Interleukin 10, business.industry, Active principle, Endothelial Cells, AMPS, 2-Acrylamido-2-MethylPropane-Sulfonic acid, EPR, Enhanced Permeability and Retention, FDA, Food and Drug Administration, MAPK, Mitogen Activated Protein Kinase, Biomimetic nanoparticles, LPS, LipoPolySaccharide, Pre-clinical assessment, MPSS, MethylPrednisolone Sodium Succinate, Cancer research, Nanoparticles, ELVIS, Extravasation through Leaky Vasculature and subsequent Inflammatory cell-mediated Sequestration, business, IFN-γ, Interferon gamma |
| الوصف: | Inflammation, a common feature of many diseases, is an essential immune response that enables survival and maintains tissue homeostasis. However, in some conditions, the inflammatory process becomes detrimental, contributing to the pathogenesis of a disease. Targeting inflammation by using nanomedicines (i.e. nanoparticles loaded with a therapeutic active principle), either through the recognition of molecules overexpressed onto the surface of activated macrophages or endothelial cells, or through enhanced vasculature permeability, or even through biomimicry, offers a promising solution for the treatment of inflammatory diseases. After providing a brief insight on the pathophysiology of inflammation and current therapeutic strategies, the review will discuss, at a pre-clinical stage, the main innovative nanomedicine approaches that have been proposed in the past five years for the resolution of inflammatory disorders, finally focusing on those currently in clinical trials. Graphical Abstract Unlabelled Image Highlights • Inflammation is an essential immune response that enables survival and maintains tissue homeostasis. • Sometimes the inflammatory process becomes detrimental, contributing to a disease development. • Conventional pharmacological treatments may result in off-target side effects and toxicity. • Innovative nanomedicines show significant therapeutic improvements in pre-clinical models. • Clinical translation remains limited due to the complexity of both inflammatory diseases and nanomedicines development. |
| اللغة: | English |
| تدمد: | 0169-409X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c0b83d8ad1c4e5e69f43542fb2ec71Test https://hal.archives-ouvertes.fr/hal-03493936Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1c0b83d8ad1c4e5e69f43542fb2ec71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0169409X |
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