دورية أكاديمية
Multimodal population brain imaging in the UK Biobank prospective epidemiological study
| العنوان: | Multimodal population brain imaging in the UK Biobank prospective epidemiological study |
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| المؤلفون: | Miller, KL, Alfaro-Almagro, F, Bangerter, NK, Thomas, DL, Yacoub, E, Xu, J, Bartsch, AJ, Jbabdi, S, Sotiropoulos, SN, Andersson, JL, Griffanti, L, Douaud, G, Okell, TW, Weale, P, Dragonu, I, Garratt, S, Hudson, S, Collins, R, Jenkinson, M, Matthews, PM, Smith, SM |
| المساهمون: | Engineering & Physical Science Research Council (EPSRC), Biogen Idec Ltd, UK DRI Ltd, Medical Research Council (MRC) |
| المصدر: | 1536 ; 1523 |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2016 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, CEREBRAL WHITE-MATTER, BONE-MINERAL DENSITY, MAGNETIC-RESONANCE, DIFFUSION TENSOR, ALZHEIMERS-DISEASE, CONNECTIVITY, DETERMINANTS, TRACTOGRAPHY, FRAMEWORK, AMYGDALA, Adult, Aged, Biological Specimen Banks, Brain, Epidemiologic Studies, Female, Humans, Male, Middle Aged, Neuroimaging, Prospective Studies, Risk Factors, United Kingdom, Neurology & Neurosurgery, 1109 Neurosciences, 1701 Psychology |
| الوصف: | Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1097-6256 |
| العلاقة: | Nature Neuroscience; http://hdl.handle.net/10044/1/44973Test; EP/N014529/1; PO 11024; MR/M024903/1; N/A |
| DOI: | 10.1038/nn.4393 |
| الإتاحة: | https://doi.org/10.1038/nn.4393Test http://hdl.handle.net/10044/1/44973Test |
| حقوق: | © 2016 Nature America, Inc., part of Springer Nature. All rights reserved. |
| رقم الانضمام: | edsbas.BAEB8B13 |
| قاعدة البيانات: | BASE |
| تدمد: | 10976256 |
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| DOI: | 10.1038/nn.4393 |