دورية أكاديمية
NK cell intrinsic regulation of MIP-1α by granzyme M
| العنوان: | NK cell intrinsic regulation of MIP-1α by granzyme M |
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| المؤلفون: | Baschuk, N., Wang, N., Watt, S. V., Halse, H., House, C., Bird, P. I., Strugnell, R., Trapani, J. A., Smyth, M. J., Andrews, D. M. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2014 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | NK cells, Granzyme M, MIP-1α, Listeria monocytogenes infection, 1306 Cancer Research, 1307 Cell Biology, 2403 Immunology, 2804 Cellular and Molecular Neuroscience |
| الوصف: | Granzymes are generally recognized for their capacity to induce various pathways of perforin-dependent target cell death. Within this serine protease family, Granzyme M (GrzM) is unique owing to its preferential expression in innate effectors such as natural killer (NK) cells. During Listeria monocytogenes infection, we observed markedly reduced secretion of macrophage inflammatory protein-1 alpha (MIP-1α) in livers of GrzM-deficient mice, which resulted in significantly impaired NK cell recruitment. Direct stimulation with IL-12 and IL-15 demonstrated that GrzM was required for maximal secretion of active MIP-1α. This effect was not due to reduced protein induction but resulted from heightened intracellular accumulation of MIP-1α, with reduced release. These results demonstrate that GrzM is a critical mediator of innate immunity that can regulate chemotactic networks and has an important role in the initiation of immune responses and pathogen control. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-4889 |
| العلاقة: | orcid:0000-0001-7098-7240; 628302; 606788; Not set; 1028425 |
| الإتاحة: | https://doi.org/10.1038/cddis.2014.74Test https://espace.library.uq.edu.au/view/UQ:328566Test |
| رقم الانضمام: | edsbas.CFF1E679 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20414889 |
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