Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner
| العنوان: | Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner |
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| المؤلفون: | Rousseau-Ralliard, Delphine, Richard, Christophe, Hoarau, Pauline, Lallemand, Marie-Sylvie, Morillon, Lucie, Aubrière, Marie-Christine, Valentino, Sarah A, Dahirel, Michèle, Guinot, Marine, Fournier, Natalie, Morin, Gwendoline, Mourier, Eve, Camous, Sylvaine, Slama, Rémy, Cassee, Flemming R, Couturier-Tarrade, Anne, Chavatte-Palmer, Pascale, IRAS OH Toxicology, dIRAS RA-1 |
| المساهمون: | IRAS OH Toxicology, dIRAS RA-1, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Lipides : systèmes analytiques et biologiques (Lip(Sys)²), Université Paris-Saclay, Sciences de l'Animal et de l'Aliment de Jouy (SAAJ), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Utrecht University [Utrecht], Chavatte-Palmer, Pascale, École nationale vétérinaire - Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | Environmental Research Environmental Research, Elsevier, 2021, 200, pp.111690. ⟨10.1016/j.envres.2021.111690⟩ Environmental Research, 2021, 200, pp.111690. ⟨10.1016/j.envres.2021.111690⟩ Environmental Research, 200, 1. Academic Press Inc. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Offspring, [SDV]Life Sciences [q-bio], Birth weight, Gestational exposure, Physiology, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Environmental Science(all), Air Pollution, 11. Sustainability, Fetal programming, medicine, Animals, Humans, Weaning, 030212 general & internal medicine, Vehicle Emissions, 030304 developmental biology, General Environmental Science, 2. Zero hunger, Intergenerational effect, 0303 health sciences, Inhalation, business.industry, Adult offspring, diesel exhaust, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Blood pressure, Rabbit biomedical model, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cardiovascular Diseases, Maternal Exposure, 13. Climate action, In utero, Prenatal Exposure Delayed Effects, Gestation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Rabbits, Metabolic syndrome, business |
| الوصف: | Background Results from observational and experimental studies indicate that exposure to air pollutants during gestation reduces birth weight, whereas little is known on potential cardiometabolic consequences for the offspring at adulthood. Objectives Our aim was to evaluate the long-term effects of gestational exposure to diesel engine exhaust (DE) on adult offspring phenotype in a rabbit model. Methods The protocol was designed to mimic human exposure in large European cities. Females rabbits were exposed to diluted (1 mg/m3) DE (exposed, n = 9) or clean air (controls, n = 7), from 3 days after mating, 2 h/d and 5 d/wk in a nose-only inhalation system throughout gestation (gestation days 3–27). After birth and weaning, 72 offspring (47 exposed and 25 controls) were raised until adulthood (7.5 months) to evaluate their cardio-metabolic status, including the monitoring of body weight and food intake, fasting biochemistry, body composition (iDXA), cardiovascular parameters and glucose tolerance. After a metabolic challenge (high fat diet in males and gestation in females), animals were euthanized for postmortem phenotyping. Results Sex-specific responses to maternal exposure were observed in adult offspring. Age-related increases in blood pressure (p = 0.058), glycaemia (p = 0.029), and perirenal fat mass (p = 0.026) as well as reductions in HDL-cholesterol (p = 0.025) and fat-to-body weight ratio (p = 0.011) were observed in exposed males, suggesting a metabolic syndrome. Almost only trends were observed in exposed females with higher triglycerides and decreased bone density compared to control females. Metabolic challenges triggered or amplified some biological responses, especially in females. Conclusions In utero exposure to air pollution predisposed rabbit offspring to cardiometabolic disorders in a sex-specific manner. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0013-9351 1096-0953 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182c1847c8258057b6eade11486dd47aTest https://doi.org/10.1016/j.envres.2021.111690Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....182c1847c8258057b6eade11486dd47a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00139351 10960953 |
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