دورية أكاديمية
Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: a narrative review
| العنوان: | Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: a narrative review |
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| المؤلفون: | Diallo, K, Feteh, VF, Ibe, L, Antonio, M, Caugant, DA, Du Plessis, M, Deghmane, A-E, Feavers, IM, Fernandez, K, Fox, LM, Rodrigues, CMC, Ronveaux, O, Taha, M-K, Wang, X, Brueggemann, AB, Maiden, MCJ, Harrison, OB |
| المساهمون: | Wellcome Trust |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, Research & Experimental, General & Internal Medicine, Research & Experimental Medicine, Meningitis, Bacteria, Molecular diagnostics, PCR, RT-PCR, LAMP assay, Whole Genome Sequence data, 1103 Clinical Sciences, 1117 Public Health and Health Services |
| الوصف: | Bacterial meningitis is a major global cause of morbidity and mortality. Rapid identification of the aetiological agent of meningitis is essential for clinical and public health management and disease prevention given the wide range of pathogens that cause the clinical syndrome and the availability of vaccines that protect against some, but not all, of these. Since microbiological culture is complex, slow, and often impacted by prior antimicrobial treatment of the patient, molecular diagnostic assays have been developed for bacterial detection. Distinguishing between meningitis caused by Neisseria meningitidis (meningococcus), Streptococcus pneumoniae (pneumococcus), Haemophilus influenzae, and Streptococcus agalactiae and identifying their polysaccharide capsules is especially important. Here, we review methods used in the identification of these bacteria, providing an up-to-date account of available assays, allowing clinicians and diagnostic laboratories to make informed decisions about which assays to use. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-3964 |
| العلاقة: | EBioMedicine; http://hdl.handle.net/10044/1/88291Test; 04992/Z/14/Z |
| DOI: | 10.1016/j.ebiom.2021.103274 |
| الإتاحة: | https://doi.org/10.1016/j.ebiom.2021.103274Test http://hdl.handle.net/10044/1/88291Test |
| حقوق: | © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0Test/) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.49157AE9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2021.103274 |