دورية أكاديمية
Structural brain changes in medically refractory focal epilepsy resemble premature brain aging
| العنوان: | Structural brain changes in medically refractory focal epilepsy resemble premature brain aging |
|---|---|
| المؤلفون: | Pardoe, HR, Cole, JH, Blackmon, K, Thesen, T, Kuzniecky, R |
| المصدر: | 32 ; 28 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Machine learning, Neuroimaging, Seizures, TEMPORAL-LOBE EPILEPSY, VOXEL-BASED MORPHOMETRY, DYSPLASIA TYPE-II, CORTICAL DYSPLASIA, GRAY-MATTER, MRI, THICKNESS, ATROPHY, SCHIZOPHRENIA, CONNECTOME, Human Epilepsy Project Investigators, 1103 Clinical Sciences, Neurology & Neurosurgery |
| الوصف: | Objective: We used whole brain T1-weighted MRIto estimate the age of individuals with medically refractory focal epilepsy, and compared with individuals with newly diagnosed focal epilepsy and healthy controls. The difference between neuroanatomical age and chronological age was compared between the three groups. Methods: Neuroanatomical age was estimated using a machine learning-based method that was trained using structural MRI scans from a large independent healthy control sample (N = 2001). The prediction model was then used to estimate age from MRI scans obtained from newly diagnosed focal epilepsy patients (N = 42), medically refractory focal epilepsy patients (N = 94) and healthy controls (N = 74). Results: Individuals with medically refractory epilepsy had a difference between predicted brain age and chronological age that was on average 4.5 years older than healthy controls (p = 4.6 × 10−5). No significant differences were observed in newly diagnosed focal epilepsy. Earlier age of onset was associated with an increased brain age difference in the medically refractory group (p = 0.034). Significance: Medically refractory focal epilepsy is associated with structural brain changes that resemble premature brain aging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0920-1211 |
| العلاقة: | Epilepsy Research; http://hdl.handle.net/10044/1/49994Test; https://dx.doi.org/10.1016/j.eplepsyres.2017.03.007Test |
| DOI: | 10.1016/j.eplepsyres.2017.03.007 |
| الإتاحة: | https://doi.org/10.1016/j.eplepsyres.2017.03.007Test http://hdl.handle.net/10044/1/49994Test |
| حقوق: | © 2017 Elsevier B.V. All rights reserved. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.4866EBE3 |
| قاعدة البيانات: | BASE |
| تدمد: | 09201211 |
|---|---|
| DOI: | 10.1016/j.eplepsyres.2017.03.007 |