التفاصيل البيبلوغرافية
العنوان:
Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
المؤلفون:
Steg, PG , Szarek, M , Bhatt, DL , Bittner, VA , Bregeault, M-F , Dalby, AJ , Diaz, R , Edelberg, JM , Goodman, SG , Hanotin, C , Harrington, RA , Jukema, JW , Lecorps, G , Mahaffey, KW , Moryusef, A , Ostadal, P , Parkhomenko, A , Pordy, R , Roe, MT , Tricoci, P , Vogel, R , White, HD , Zeiher, AM , Schwartz, GG , Sasiela, WJ , Tamby, J-F , Aylward, PE , Drexel, H , Sinnaeve, P , Dilic, M , Gotcheva, NN , Prieto, J-C , Yong, H , Lopez-Jaramillo, P , Pecin, I , Reiner, Z , Poulsen, SH , Viigimaa, M , Nieminen, MS , Danchin, N , Chumburidze, V , Marx, N , Liberopoulos, E , Valdovinos, PCM , Tse, H-F , Kiss, RG , Xavier, D , Zahger, D , Valgimigli, M , Kimura, T , Kim, HS , Kim, S-H , Kedev, S , Erglis, A , Laucevicius, A , Yusoff, K , Lopez, R , Ramos Lopez, GA , Alings, M , Halvorsen, S , Correa Flores, RM , Sy, RG , Budaj, A , Morais, J , Dorobantu, M , Karpov, Y , Ristic, AD , Chua, T , Murin, J , Fras, Z , Tunon, J , De Silva, HA , Hagstrom, E , Muller, C , Chiang, C-E , Sritara, P , Guneri, S , Ray, KK , Moriarty, PM , Chaitman, B , Kelsey, SF , Olsson, AG , Rouleau, J-L , Simoons, ML , Alexander, K , Meloni, C , Rosenson, R , Sijbrands, EJG , Alexander, JH , Armaganijan, L , Bagai, A , Bahit, MC , Brennan, JM , Clifton, S , DeVore, AD , Deloatch, S , Dickey, S , Dombrowski, K , Ducrocq, G , Eapen, Z , Endsley, P , Eppinger, A , Harrison, RW , Hess, CN , Hlatky, MA , Jordan, JD , Knowles, JW , Kolls, BJ , Kong, DF , Leonardi, S , Lillis, L , Maron, DJ , Marcus, J , Mathews, R , Mehta, RH , Mentz, RJ , Moreira, HG , Patel, CB , Pereira, SB , Perkins, L , Povsic, TJ , Puymirat, E , Jones, WS , Shah, BR , Sherwood, MW , Stringfellow, K , Sujjavanich, D , Toma, M , Van Diepen, SFP , Wilson, MD , Yan, AT-K , Lopes, RD , Trotter, C , Schiavi, LB , Garrido, M , Alvarisqueta, AF , Sassone, SA , Bordonava, AP , Alves De Lima, AE , Schmidberg, JM , Duronto, EA , Caruso, OC , Novaretto, LP , Angel Hominal, M , Montana, OR , Caccavo, A , Gomez Vilamajo, OA , Lorenzatti, AJ , Cartasegna, LR , Paterlini, GA , Mackinnon, IJ , Caime, GD , Amuchastegui, M , Salomone, R , Codutti, OR , Jure, HO , Bono, JOE , Hrabar, AD , Vallejos, JA , Ahuad Guerrero, RA , Novoa, F , Patocchi, CA , Zaidman, CJ , Giuliano, ME , Dran, RD , Vico, ML , Carnero, GS , Guzman, PN , Medrano Allende, JC , Garcia Brasca, DF , Bustamante Labarta, MH , Nani, S , Blumberg, EDS , Colombo, HR , Liberman, A , Luciardi, HL , Waisman, GD , Berli, MA , Duran, ROG , Cestari, HG , Luquez, HA , Giordano, JA , Saavedra, SS , Zapata, G , Costamagna, O , Llois, S , Waites, JH , Collins, N , Soward, A , Hii, CLS , Shaw, J , Arstall, MA , Horowitz, J , Rogers, JF , Colquhoun, D , Oqueli Flores, RE , Roberts-Thomson, P , Raffel, O , Lehman, SJ , Aroney, C , Coverdale, SGM , Garrahy, PJ , Starmer, G , Sader, M , Carroll, PA , Dick, R , Zweiker, R , Hoppe, U , Huber, K , Berger, R , Weidinger, F , Faes, D , Hermans, K , Pirenne, B , Leone, A , Hoffer, E , Vrolix, MCM , De Wolf, L , Wollaert, B , Castadot, M , Dujardin, K , Beauloye, C , Vervoort, G , Striekwold, H , Convens, C , Roosen, J , Barbato, E , Claeys, M , Cools, F , Terzic, I , Barakovic, F , Midzic, Z , Pojskic, B , Fazlibegovic, E , Durak-Nalbantic, A , Vulic, D , Muslibegovic, A , Goronja, B , Reis, G , Sousa, L , Nicolau, JC , Giorgeto, FE , Silva, RP , Maia, LN , Rech, R , Rossi, PRF , Cerqueira, MJAG , Duda, N , Kalil, R , Kormann, A , Abrantes, JAM , Pimentel Filho, P , Soggia, AP , De Santos, MON , Neuenschwander, F , Bodanese, LC , Michalaros, YL , Eliaschewitz, FG , Vidotti, MH , Leaes, PE , Botelho, RV , Kaiser, S , Fernandes Manenti, ERF , Precoma, DB , Moura Jorge, JC , Silva, PGMDB , Silveira, JA , Saporito, W , Marin Neto, JA , Feitosa, GS , Ritt, LEF , De Souza, JA , Costa, F , Souza, WKSB , Reis, HJL , Machado, L , Aidar Ayoub, JC , Todorov, GV , Nikolov, FP , Velcheva, ES , Tzekova, ML , Benov, HO , Petranov, SL , Tumbev, HS , Shehova-Yankova, NS , Markov, DT , Raev, DH , Mollov, MN , Kichukov, KN , Ilieva-Pandeva, KA , Ivanova, R , Mincheva, VM , Lazov, PV , Dimov, BI , Senaratne, M , Stone, J , Kornder, J , Pearce, S , Dion, D , Savard, D , Pesant, Y , Pandey, A , Robinson, S , Gosselin, G , Vizel, S , Hoag, G , Bourgeois, R , Morisset, A , Sabbah, E , Sussex, B , Kouz, S , MacDonald, P , Diaz, A , Michaud, N , Fell, D , Leung, R , Vuurmans, T , Lai, C , Nigro, F , Davies, R , Nogareda, G , Vijayaraghavan, R , Ducas, J , Lepage, S , Mehta, S , Cha, J , Dupuis, R , Fong, P , Rodes-Cabau, J , Fadlallah, H , Cleveland, D , Thao, H , Bata, I , Hameed, A , Pincetti, C , Potthoff, S , Prieto, JC , Acevedo, M , Aguirre, A , Vejar, M , Yanez, M , Araneda, G , Fernandez, M , Perez, L , Varleta, P , Florenzano, F , Huidobro, L , Raffo, CA , Olivares, C , Nahuelpan, L , Montecinos, H , Chen, J , Dong, Y , Huang, W , Wang, J , Huang, S , Yao, Z , Li, X , Cui, L , Lin, W , Sun, Y , Li, J , Zhang, X , Zhu, H , Chen, D , Huang, L , Dong, S , Su, G , Xu, B , Su, X , Cheng, X , Lin, J , Zong, W , Li, H , Feng, Y , Xu, D , Yang, X , Ke, Y , Lin, X , Zhang, Z , Zheng, Z , Luo, Z , Chen, Y , Ding, C , Zheng, Y , Peng, D , Li, Y , Wei, M , Liu, S , Yu, Y , Qu, B , Jiang, W , Zhou, Y , Zhao, X , Yuan, Z , Guo, Y , Xu, X , Shi, X , Ge, J , Fu, G , Bai, F , Fang, W , Shou, X , Lu, Q , Zhang, R , Zhu, J , Xu, Y , Fan, Z , Li, T , Wu, C , Jaramillo, N , Vallejo, GS , Botia, DCL , Lopez, RB , De Salazar, DIM , Bonfanti, AJC , Higuera, JD , Silva, SIB , Lozada, HJG , Arroyo, JAC , Mendoza, JLA , Ruiz, RLF , Jatin, FGM , Herazo, AS , Parada, JC , Triana, MAU , Strozzi, M , Car, S , Milicic, D , Bencic, ML , Pintaric, H , Prvulovic, D , Sikic, J , Persic, V , Mileta, D , Stambuk, K , Zdravko, B , Tomulic, V , Krstulovic, SM , Starcevic, B , Spinar, J , Horak, D , Stasek, J , Alan, D , Machova, V , Linhart, A , Novotny, V , Kaucak, V , Rokyta, R , Naplava, R , Coufal, Z , Adamkova, V , Podpera, I , Zizka, J , Motovska, Z , Marusincova, I , Svab, P , Heinc, P , Kuchar, J , Povolny, P , Matuska, J , Raungaard, B , Clemmensen, P , Bang, LE , May, O , Bottcher, M , Hove, JD , Frost, L , Gislason, G , Larsen, J , Johansen, PB , Hald, F , Jeppesen, J , Nielsen, T , Kristensen, KS , Walichiewicz, PM , Lomholdt, JD , Klausen, IC , Nielsen, PK , Davidsen, F , Videbaek, L , Soots, M , Vahula, V , Hedman, A , Soopold, U , Martsin, K , Kristjan, A , Taskinen, M-R , Porthan, K , Airaksinen, JK , Juonala, M , Kiviniemi, T , Vikman, S , Posio, P , Taurio, J , Huikuri, H , Kaikkonen, K , Coste, P , Ferrari, E , Morel, O , Montalescot, G , Barone-Rochette, G , Mansourati, J , Cottin, Y , Leclercq, F , Belhassane, A , Delarche, N , Boccara, F , Paganelli, F , Clerc, J , Schiele, F , Aboyans, V , Probst, V , Berland, J , Lefevre, T , Citron, B , Khintibidze, I , Shaburishvili, T , Pagava, Z , Ghlonti, R , Lominadze, Z , Khabeishvili, G , Hemetsberger, R , Rauch-Kroehnert, U , Stratmann, M , Appel, K-F , Schmidt, E , Omran, H , Stellbrink, C , Dorsel, T , Lianopoulos, E , Marx, R , Zirlik, A , Schellenberg, D , Heitzer, T , Laufs, U , Gielen, S , Winkelmann, B , Behrens, S , Sydow, K , Simonis, G , Muenzel, T , Werner, N , Leggewie, S , Boecker, D , Braun-Dullaeus, R , Toursarkissian, N , Jeserich, M , Weissbrodt, M , Schaeufele, T , Weil, J , Voeller, H , Waltenberger, J , Natour, M , Schmitt, S , Steiner, S , Heidenreich, L , Gremmler, U , Killat, H , Rieker, W , Patsilinakos, S , Kartalis, A , Manolis, A , Sionis, D , Skoumas, I , Athyros, V , Vardas, P , Parthenakis, F , Alexopoulos, D , Hahalis, G , Lekakis, J , Hatzitolios, A , Ovando, SRF , Benecke, JLA , De Leon, ERR , Yan, BPY , Siu, DCW , Turi, T , Merkely, B , Ungi, I , Lupkovics, G , Nagy, L , Katona, A , Edes, I , Muller, G , Horvath, I , Kapin, T , Falukozy, J , Kumbla, M , Sandhu, M , Annam, S , Proddutur, NR , Premchand, RK , Mahajan, A , Abhyanakar, AD , Kerkar, P , Govinda, RA , Oomman, A , Sinha, D , Patil, SN , Kahali, D , Sawhney, J , Joshi, AB , Chaudhary, S , Harkut, P , Guha, S , Porwal, S , Jujjuru, S , Pothineni, RB , Monteiro, MR , Khan, A , Iyengar, SS , Grewal, JS , Chopda, M , Fulwani, MC , Patange, A , Chopra, VK , Goyal, NK , Shinde, R , Manakshe, GV , Patki, N , Sethi, S , Munusamy, V , Karna, S , Adhyapak, S , Pandurangi, U , Mathur, R , Kalashetti, S , Bhagwat, A , Raghuraman, B , Yerra, SK , Bhansali, P , Borse, R , Das, S , Abdullakutty, J , Saathe, S , Palimkar, P , Abdullkutty, J , Sathe, S , Atar, S , Shechter, M , Mosseri, M , Arbel, Y , Lotan, C , Rosenschein, U , Katz, A , Henkin, Y , Francis, A , Klutstein, M , Nikolsky, E , Turgeman, Y , Halabi, M , Kornowski, R , Jonas, M , Amir, O , Rozenman, Y , Fuchs, S , Hussein, O , Gavish, D , Vered, Z , Caraco, Y , Elias, M , Tov, N , Lishner, M , Elias, N , Piovaccari, G , De Pellegrin, A , Guardigli, G , Licciardello, G , Auguadro, C , Cuccia, C , Salvioni, A , Musumeci, G , Calabro, P , Novo, S , Faggiano, P , De Cesare, NB , Berti, S , Cavallini, C , Puccioni, E , Galvani, M , Tespili, M , Piatti, P , Palvarini, M , De Luca, G , Violini, R , De Leo, A , Filardi, PP , Ferratini, M , Ricca, V , Dai, K , Kamiya, H , Ando, K , Takeda, Y , Morino, Y , Hata, Y , Kimura, K , Kishi, K , Michishita, I , Uehara, H , Higashikata, T , Hirayama, A , Hirooka, K , Sakagami, S , Taguchi, S , Koike, A , Fujinaga, H , Koba, S , Kozuma, K , Kawasaki, T , Ono, Y , Shimizu, M , Katsuda, Y , Wada, A , Shinke, T , Ako, J , Fujii, K , Takahashi, T , Sakamoto, T , Furukawa, Y , Sugino, H , Mano, T , Utsu, N , Ito, K , Haraguchi, T , Ueda, Y , Nishibe, A , Fujimoto, K , Masutani, M , Yoon, JH , Park, HS , Chae, I-H , Kim, MH , Jeong, MH , Rha, S , Kim, C , Kim, H-S , Hong, T , Tahk, S-J , Kim, Y , Busmane, A , Pontaga, N , Strelnieks, A , Mintale, I , Sime, I , Petrulioniene, Z , Kavaliauskiene, R , Jurgaitiene, R , Sakalyte, G , Slapikas, R , Norkiene, S , Misonis, N , Kibarskis, A , Kubilius, R , Bojovski, S , Lozance, N , Kjovkaroski, A , Doncovska, S , Ong, TK , Kasim, S , Maskon, O , Kandasamy, B , Liew, HB , Mohamed, WMIW , Garcia Castillo, A , Carrillo Calvillo, J , Fajardo Campos, P , Nunez Fragoso, JC , Bayram Llamas, EA , Alcocer Gamba, MA , Carranza Madrigal, J , Gonzalez Salas, LG , Lopez Rosas, E , Gonzalez Diaz, B , Salcido Vazquez, E , Nacoud Ackar, A , Llamas Esperon, GA , Martinez Sanchez, CR , Guerrero De Leon, M , Suarez Otero, R , Fanghanel Salmon, G , Perez Rios, JA , Garza Ruiz, JA , Breedveld, RW , Hoogslag, PAM , Suryapranata, H , Oomen, A , Wiersma, JJ , Van Der Wal, RMA , Van Huysduynen-Monraats, PSH , Karalis, I , Verdel, GJE , Brueren, BRG , Troquay, RP , Viergever, EP , Al-Windy, NYY , Bartels, GL , Cornel, JH , Hermans, WRM , Herrman, JPR , Bos, RJ , Groutars, RGEJ , Van Der Zwaan, CC , Kaplan, R , Ronner, E , Groenemeijer, BE , Bronzwaer, PNA , Liem, AAH , Rensing, BJWM , Bokern, MJJA , Nijmeijer, R , Hersbach, FMRJ , Willems, FF , Gosselink, ATM , Elliott, J , Wilkins, G , Fisher, R , Scott, D , Hart, H , Stewart, R , Harding, S , Ternouth, I , Fisher, N , Aitken, D , Anscombe, R , Davidson, L , Tomala, T , Nygard, O , Sparby, JA , Andersen, K , Gullestad, L , Jortveit, J , Munk, PS , Singsaas, EG , Hurtig, U , Calderon Ticona, JR , Durand Velasquez, JR , Negron Miguel, SA , Sanabria Perez, ES , Carrion Chambilla, JM , Chavez Ayala, CA , Castillo Leon, RP , Vargas Gonzales, RJ , Hernandez Zuniga, JD , Camacho Cosavalente, LA , Bravo Mannucci, JE , Heredia Landeo, J , Llerena Navarro, NC , Roldan Concha, YM , Rodriguez Chavez, V-CE , Anchante Hernandez, HA , Zea Nunez, CA , Mogrovejo Ramos, W , Ferrolino, A , Sy, RAG , Tirador, L , Matiga, G , Coching, RM , Bernan, A , Rogelio, G , Morales, DD , Tan, E , Sulit, DJ , Wlodarczak, A , Jaworska, K , Skonieczny, G , Pawlowicz, L , Wojewod, P , Busz-Papiez, B , Bednarski, J , Goch, A , Staneta, P , Dulak, E , Saminsk, K , Krasowski, W , Sudnik, W , Zurakowski, A , Skorski, M , Lysek, R , Miklaszewicz, B , Kubica, J , Lipko, JA , Kostarska-Srokosz, E , Piepiorka, M , Drzewiecka, A , Sciborski, R , Stasiewski, A , Blicharski, T , Bystryk, L , Szpajer, M , Korol, M , Czerski, T , Mirek-Bryniarska, E , Gniot, J , Lubinski, A , Gorny, J , Franek, E , Raczak, G , Szwed, H , Monteiro, P , Bastos, JM , Pereira, HH , Martins, D , Seixo, F , Mendonca, C , Botelho, A , Minescu, B , Istratoaie, O , Tesloianu, DN , Cristian, G , Podoleanu, CGC , Constantinescu, MCA , Bengus, CM , Militaru, C , Rosu, D , Parepa, IR , Matei, AV , Alexandru, TM , Coman, I , Cioranu, RS , Dimulescu, D , Shvarts, Y , Orlikova, O , Kobalava, Z , Barbarash, OL , Markov, V , Lyamina, N , Gordienko, A , Zrazhevsky, K , Vishnevsky, AY , Gurevich, V , Stryuk, R , Lomakin, NV , Bokarev, I , Shalaev, S , Khaisheva, L , Chizhov, P , Viktorova, I , Osokina, N , Akatova, E , Chumakova, G , Libov, I , Voevoda, MI , Tretyakova, TV , Baranov, E , Shustov, S , Yakushin, S , Gordeev, I , Khasanov, N , Reshetko, O , Sotnikova, T , Molchanova, O , Nikolaev, K , Gapon, L , Baranova, E , Shogenov, Z , Kosmachova, E , Povzun, A , Egorova, L , Tyrenko, VV , Ivanov, IG , Kanorsky, S , Simic, D , Ivanovic, N , Davidovic, G , Tasic, N , Asanin, MR , Stojic, S , Apostolovic, SR , Ilic, S , Putnikovic, B , Stankovic, A , Arandjelovic, A , Radovanovic, S , Balinovac, J , Dincic, DV , Seferovic, P , Dodic, S , Dimkovic, S , Poh, K-K , Ong, HY , Micko, K , Nociar, J , Pella, D , Fulop, P , Hranai, M , Palka, J , Mazur, J , Majercak, I , Dzupina, A , Fazekas, F , Gonsorcik, J , Bugan, V , Selecky, J , Kamensky, G , Strbova, J , Smik, R , Dukat, A , Olexa, P , Zuran, I , Poklukar, J , Suligoj, NC , Cevc, M , Cyster, HP , Ranjith, N , Corbett, C , Bayat, J , Makotoko, EM , Kapp, IE , Basson, MMDV , Lottering, H , Van Zyl, LJ , Sebastian, PJ , Pillay, T , Saaiman, JA , Commerford, PJ , Cassimjee, S , Ebrahim, IO , Sarvan, M , Mynhardt, JH , Reuter, H , Moodley, R , Vida, M , Cequier Fillat, AR , Peris, VB , Jimenez, FF , Marin, F , Cruz Fernandez, JM , Gil-Extremera, B , Diz, FW , Garcia-Dorado, D , Iniguez, A , Tunon Fernandez, J , Gonzalez-Juanatey, JR , Fernandez Portales, J , Civeira Murillo, F , Matas Pericas, L , Luis Zamorano, J , De Mora Martin, M , Bruguera Cortada, J , Alonso Martin, JJ , De Berrazueta Fernandez, JR , Diaz Fernandez, JF , Garcia Lledo, JA , Cosin Sales, J , Botas Rodriguez, J , Gusi Tragant, G , Benedicto, A , Gonzalez-Juanatey, C , Camprubi Potau, M , Plaza Perez, I , Moris De La Tassa, C , Loma-Osorio Rincon, P , Balaguer Recena, J , Escudier, JM , Coca Payeras, A , Alonso Orcajo, N , Valdivielso, P , Constantine, G , Haniffa, R , Tissera, N , Amarasekera, S , Fernando, N , Jayawardena, J , Santharaj, W , Ekanayaka, R , Mendis, S , Senaratne, V , Mayurathan, G , Sirisena, T , Rajapaksha, A , Herath, JI , Amarasena, N , Berglund, S , Rasmanis, G , Witt, N , Mourtzinis, G , Nicol, P , Hansen, O , Romeo, S , Jensen, SA , Torstensson, I , Ahremark, U , Sundelin, T , Moccetti, T , Mach, F , Binder, R , Tsai, W-C , Ueng, K-C , Lai, W-T , Liu, M-E , Hwang, J-J , Yin, W-H , Hsieh, I-C , Lin, WH , Kuo, J-Y , Huang, T-Y , Fang, C-Y , Kaewsuwanna, P , Soonfuang, W , Jintapakorn, W , Sukonthasarn, A , Wongpraparut, N , Sastravaha, K , Sansanayudh, N , Kehasukcharoen, W , Piyayotai, D , Chotnoparatpat, P , Camsari, A , Kultursay, H , Mutlu, B , Ersanli, M , Demirtas, M , Kirma, C , Ural, E , Koldas, L , Karpenko, O , Prokhorov, A , Vakaluyk, I , Myshanych, H , Reshotko, D , Batushkin, V , Rudenko, L , Kovalskyi, I , Kushnir, M , Tseluyko, V , Mostovoy, Y , Stanislavchuk, M , Kyiak, Y , Karpenko, Y , Malynovsky, Y , Klantsa, A , Kutniy, O , Amosova, E , Tashchuk, V , Leshchuk, O , Rishko, M , Kopytsya, M , Yagensky, A , Vatutin, M , Bagriy, A , Barna, OM , Ushakov, O , Dzyak, G , Goloborodko, B , Rudenko, A , Zheleznyy, V , Trevelyan, J , Zaman, A , Lee, K , Moriarty, A , Aggarwal, RK , Clifford, P , Wong, Y-K , Iqbal, SMR , Subkovas, E , Braganza, D , Sarkar, D , Storey, R , Griffiths, H , Mcclure, S , Muthusamy, R , Kurian, J , Levy, T , Barr, C , Kadr, H , Gerber, R , Simaitis, A , Soran, H , Mathur, A , Brodison, A , Oliver, R , Mudawi, T , Reynolds, T , Sharman, D , Butler, R , Wilkinson, P , Lip, GYH , Halcox, J , Vardi, G , Baldari, D , Brabham, D , Treasure, C , Dahl, C , Palmer, B , Wiseman, A , Puri, S , Mohart, AE , Ince, C , Flores, E , Wright, S , Cheng, S-C , Rosenberg, M , Rogers, W , Kosinski, E , Forgosh, L , Waltman, J , Khan, M , Shoukfeh, M , Dagher, G , Lieber, I , Kumar, P , East, C , Krichmar, P , White, L , Knickelbine, T , Haldis, T , Gillespie, E , Suh, D , Arif, I , Akhter, F , Carlson, E , D'Urso, M , El-Ahdab, F , Nelson, W , Harris, B , Cohen, S , Carter, L , Sabatino, K , Haddad, T , Malik, A , Rao, S , Mulkay, A , Jovin, I , Klancke, K , Malhotra, V , Devarapalli, SK , Koren, M , Chandna, H , Dodds, G , Janik, M , Moran, J , Sumner, A , Kobayashi, J , Davis, W , Yazdani, S , Pasquini, J , Thakkar, M , Vedere, A , Leimbach, W , Rider, J , Singh, N , Shah, AV , Janosik, D , Pepine, C , Berman, B , Gelormini, J , Daniels, C , Keating, F , Kondo, NI , Shetty, S , Waider, W , Takata, T , Abu-Fadel, M , Shah, V , Aggarwal, R , Izzo, M , Kumar, A , Hattler, B , Link, C , Bortnick, A , Kinzfogl, G , Ghitis, A , Larry, J , Teufel, E , Kuhlman, P , Mclaurin, B , Zhang, W , Thew, S , Abbas, J , White, M , Ranadive, N , Gring, C , Henderson, D , Schuchard, T , Farhat, N , Kline, G , Mahal, S , Whitaker, J , Speirs, S , Andersen, R , Daboul, N , Horwitz, P , Ponce, G , Jafar, Z , Mcgarvey, J , Panchal, V , Voyce, S , Blok, T , Sheldon, W , Azizad, MM , Schmalfuss, C , Picone, M , Herzog, W , Lindsey, J , Nowins, R , Lepor, N , El Shahawy, M , Weintraub, H , Irimpen, A , May, W , Galski, T , Chu, A , Mody, F , Hodes, Z , Rose, G , Fairlamb, J , Lambert, C , Raisinghani, A , Abbate, A , King, M , Carey, C , Gerber, J , Younis, L , Park, HT , Vidovich, M , Knutson, T , Friedman, D , Chaleff, F , Loussararian, A , Rozeman, P , Kimmelstiel, C , Silver, K , Foster, M , Tonnessen, G , Amlani, M , Wali, A , 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المساهمون:
ODYSSEY OUTCOMES Comm, İÜC, Ege Üniversitesi, Rushton-Smith, Sophie, ODYSSEY OUTCOMES Committees and Investigators
المصدر:
Circulation Steg, P G, Szarek, M, Bhatt, D L, Bittner, V A, Bregeault, M-F, Dalby, A J, Diaz, R, Edelberg, J M, Goodman, S G, Hanotin, C, Harrington, R A, Jukema, J W, Lecorps, G, Mahaffey, K W, Moryusef, A, Ostadal, P, Parkhomenko, A, Pordy, R, Roe, M T, Tricoci, P, Vogel, R, White, H D, Zeiher, A M, Schwartz, G G, ODYSSEY OUTCOMES Committees and Investigators, Clemmensen, P, Gislason, G, Davidsen, F & Videbaek, L 2019, ' Effect of Alirocumab on Mortality After Acute Coronary Syndromes : An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial ', Circulation, vol. 140, no. 2, pp. 103-112 . https://doi.org/10.1161/CIRCULATIONAHA.118.038840Test CIRCULATION r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Circulation, 140(2), 103-112. LIPPINCOTT WILLIAMS & WILKINS Circulation : an official journal of the American Heart Association 140(2), 103-112 (2019). doi:10.1161/CIRCULATIONAHA.118.038840
سنة النشر:
2019
مصطلحات موضوعية:
Male , Cardiac & Cardiovascular Systems , MONOCLONAL-ANTIBODY , alirocumab , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , law.invention , PCSK9 , chemistry.chemical_compound , Randomized controlled trial , law , Cardiac and Cardiovascular Systems , 1102 Cardiorespiratory Medicine and Haematology , Hypercholesterolemia/blood , Kardiologi , Hazard ratio , Middle Aged , Treatment Outcome , SAFETY , Cardiology , Female , Drug Therapy, Combination , Cholesterol, LDL/antagonists & inhibitors , Cardiology and Cardiovascular Medicine , Life Sciences & Biomedicine , REDUCING LIPIDS , Akutes Koronarsyndrom , acute coronary syndrome , cholesterol , mortality , PCSK9 protein , Antibodies, Monoclonal, Humanized/administration & dosage , medicine.medical_specialty , Acute coronary syndrome , Injections, Subcutaneous , Hypercholesterolemia , Placebo , Antibodies, Monoclonal, Humanized , 1117 Public Health and Health Services , Sterblichkeit , Double-Blind Method , Physiology (medical) , Internal medicine , medicine , Humans , ddc:610 , Alirocumab , Aged , Science & Technology , Cholesterol , business.industry , EVOLOCUMAB , 1103 Clinical Sciences , Cholesterol, LDL , medicine.disease , EFFICACY , Increased risk , chemistry , Peripheral Vascular Disease , Cardiovascular System & Hematology , Cardiovascular System & Cardiology , Acute Coronary Syndrome/blood , Cholesterin , Human medicine , Hydroxymethylglutaryl-CoA Reductase Inhibitors , business , Follow-Up Studies
الوصف:
bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Tse, Hung Fat/0000-0002-9578-7808; Gislason, Gunnar H/0000-0002-0548-402X; Taskinen, Marja-Riitta/0000-0002-6229-3588; Racca, Vittorio/0000-0002-4465-3789; Keskin, Kudret/0000-0002-9049-1530; Sherwood, Matthew/0000-0002-4305-5883; Sandhu, Manjinder/0000-0003-2538-2079; Nikolaev, Konstantin/0000-0003-4601-6203; Ersanli, Murat/0000-0003-1847-3087; Raffel, Owen C/0000-0001-5470-7050; Abbate, Antonio/0000-0002-1930-785X; Muenzel, Thomas/0000-0001-5503-4150; Leonardi, Sergio/0000-0002-4800-6132; Chumakova, Galina A/0000-0002-2810-6531; Podoleanu, Cristian/0000-0001-9987-2519; Pereira, Helder/0000-0001-8656-4883; Reshetko, Olga/0000-0003-3107-7636 WOS: 000476768100007 PubMed: 31117810 Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. in a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). in the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low. Sanofi; Regeneron Pharmaceuticals, Inc. The trial was funded by Sanofi and Regeneron Pharmaceuticals, Inc.
وصف الملف:
application/pdf; Print-Electronic; application/octet-stream
اللغة:
English
تدمد:
0009-7322
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4916ac726c042210182cdbd1d204ce0Test https://hdl.handle.net/10067/1812340151162165141Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....c4916ac726c042210182cdbd1d204ce0
قاعدة البيانات:
OpenAIRE