All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS)
| العنوان: | All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS) |
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| المؤلفون: | Roelens, Maroussia, Bertisch, Barbara, Moradpour, Darius, Cerny, Andreas, Semmo, Nasser, Schmid, Patrick, Mülhaupt, Beat, Clerc, Olivier, Semela, David, Junker, Christoph, Negro, Francesco, Keiser, Olivia, Hepatitis C Cohort Study, Swiss |
| المساهمون: | University of Zurich, Roelens, Maroussia, Swiss Hepatitis C Cohort Study, Negro, F., Kaiser, L., Heim, M., Hirsch, H., Semmo, N., Suter, F., Moradpour, D., Aubert, V., Siegrist, H., Cerny, A., Martinetti-Lucchini, G., Clerc, O., Semela, D., Schmid, P., Dollenmaier, G., Müllhaupt, B., Probst-Müller, E., Benkert, P., Fabbro, T., Rutquist, M., Sluka, C., Kaiser, Laurent |
| المصدر: | Open forum infectious diseases, vol. 7, no. 8, pp. ofaa308 Roelens, Maroussia; Bertisch, Barbara; Moradpour, Darius; Cerny, Andreas; Semmo, Nasser; Schmid, Patrick; Mülhaupt, Beat; Clerc, Olivier; Semela, David; Junker, Christoph; Negro, Francesco; Keiser, Olivia; Hepatitis C Cohort Study, Swiss (2020). All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS). Open Forum Infectious Diseases, 7(8), ofaa308. Oxford University Press 10.1093/ofid/ofaa308 <http://dx.doi.org/10.1093/ofid/ofaa308Test> Open Forum Infectious Diseases, Vol. 7, No 8 (2020) P. ofaa308 Open Forum Infectious Diseases |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cohort, 610 Medicine & health, cohort, Switzerland, hepatitis C, mortality, risk factors, ddc:616.07, Hepatitis C, Major Articles, AcademicSubjects/MED00290, 10219 Clinic for Gastroenterology and Hepatology, 2728 Neurology (clinical), Risk factors, 2730 Oncology, Mortality, ddc:613 |
| الوصف: | Background.With direct-acting antiviral agents (DAAs), mortality rates and causes of death among persons with hepatitis C virus (HCV) infection may change over time. However, the emergence of such trends may be delayed by the slow progression of chronic hepatitis C. To date, detailed analyses of cause-specific mortality among HCV-infected persons over time remain limited.Methods.We evaluated changes in causes of death among Swiss Hepatitis C Cohort Study (SCCS) participants from 2008 to 2016. We analyzed risk factors for all-cause and cause-specific mortality, accounting for changes in treatment, fibrosis stage, and use of injectable drugs over time. Mortality ascertainment was completed by linking lost-to-follow-up participants to the Swiss Federal Statistical Office death registry.Results.We included 4700 SCCS participants, of whom 478 died between 2008 and 2016. The proportion of unknown causes of death decreased substantially after linkage, from 42% to 10%. Leading causes of death were liver failure (crude death rate 4.4/1000 person-years), liver cancer (3.4/1000 person-years), and nonliver cancer (2.8/1000 person-years), with an increasing proportion of cancer-related deaths over time. Cause-specific analysis showed that persons with sustained virologic response were less at risk for liver-related mortality than those never treated or treated unsuccessfully.Conclusions.Although the expected decrease in mortality is not yet observable, causes of death among HCV-infected persons have evolved over time. With the wider use of DAAs, liver-related mortality is expected to decline in the future. Continued moni-toring of cause-specific mortality will remain important to assess the long-term effect of DAAs and design effective interventions.Keywords. cohort; hepatitis C; mortality; risk factors; Switzerland. |
| وصف الملف: | ofaa308.pdf - application/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 2328-8957 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d81ecf99c14ec1a40256e587b53c08cTest https://doi.org/10.5167/uzh-198667Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d81ecf99c14ec1a40256e587b53c08c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23288957 |
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