Metabolic changes in schizophrenia and human brain evolution
| العنوان: | Metabolic changes in schizophrenia and human brain evolution |
|---|---|
| المؤلفون: | Khaitovich, P, Lockstone, HE, Wayland, MT, Tsang, TM, Jayatilaka, SD, Guo, AJ, Zhou, J, Somel, M, Harris, LW, Holmes, E, Paeaebo, S, Bahn, S |
| المساهمون: | OpenMETU, Wayland, Matthew [0000-0002-8095-858X], Apollo - University of Cambridge Repository |
| المصدر: | Genome Biology |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Pan troglodytes, Bioinformatics, Formal thought-disorder, 05 Environmental Sciences, Nmr-Spectroscopy, Gene Expression, behavioral disciplines and activities, Homo-sapiens, Cognition, mental disorders, Animals, Humans, RNA, Messenger, Gene-expression, Magnetic-resonance-spectroscopy, Nuclear Magnetic Resonance, Biomolecular, Aged, Oligonucleotide Array Sequence Analysis, Genetics & Heredity, Science & Technology, Human genome, Research, Gene Expression Profiling, Brain, 06 Biological Sciences, Middle Aged, Biological Evolution, Macaca mulatta, Positive selection, Biotechnology & Applied Microbiology, Dysfunction, Schizophrenia, Cortex, Female, 08 Information and Computing Sciences, sense organs, Proton, Energy Metabolism, Life Sciences & Biomedicine |
| الوصف: | Human cognitive evolution involved genes implicated in energy metabolism and energy-expensive brain functions that are also altered in schizophrenia, suggesting that human brains may have reached their metabolic limit, with schizophrenia as a costly by-product. Background Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA sequence and mRNA expression differences between humans and other primates but, in the absence of other information, it has proved very difficult to identify molecular pathways relevant to human cognition. Results Here, we compare changes in gene expression and metabolite concentrations in the human brain and compare them to the changes seen in a disorder known to affect human cognitive abilities, schizophrenia. We find that both genes and metabolites relating to energy metabolism and energy-expensive brain functions are altered in schizophrenia and, at the same time, appear to have changed rapidly during recent human evolution, probably as a result of positive selection. Conclusion Our findings, along with several previous studies, suggest that the evolution of human cognitive abilities was accompanied by adaptive changes in brain metabolism, potentially pushing the human brain to the limit of its metabolic capabilities. |
| وصف الملف: | application/pdf; application/msword; text/xml; application/vnd.ms-excel |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::69f4c0c5e71a63c34ee780ba74a45a82Test https://hdl.handle.net/11511/38395Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....69f4c0c5e71a63c34ee780ba74a45a82 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |