نتائج البحث - "David Lagorce"

المساهمون: Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sperandio, Olivier

المصدر: Current Pharmaceutical Design
Current Pharmaceutical Design, Bentham Science Publishers, 2012, 18 (30), pp.4648-67
Protein-Protein Interactions in Drug Discovery

مصطلحات موضوعية: Druggability, protein-protein interactions, Bioinformatics, therapeutic targets, 01 natural sciences, Drug likeness, Drug Discovery, MESH: Proteins, Protein Interaction Maps, Enzyme Inhibitors, Chemical space, MESH: Protein Interaction Maps, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], Principal Component Analysis, 0303 health sciences, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Chemistry, Drug discovery, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], MESH: Enzyme Inhibitors, Design drugs, druggability, Protein Binding, enzymes, Computational biology, chemoinformatics, G-Protein Coupled Receptor (GPCR), Article, Protein–protein interaction, Small Molecule Libraries, 03 medical and health sciences, MESH: Computer Simulation, MESH: Drug Discovery, MESH: Small Molecule Libraries, MESH: Protein Binding, Computer Simulation, Set (psychology), 030304 developmental biology, Pharmacology, MESH: Principal Component Analysis, Binding Sites, 010405 organic chemistry, Proteins, compound collection, mutations, 0104 chemical sciences, MESH: Binding Sites, ADME, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50673bbfe618e15914c8a432263c815Test
https://www.hal.inserm.fr/inserm-00828202/file/Sperandio-CurrPharmDes-Oct2012-for-HAL.pdfTest

6

Tyrosine Kinase Syk Non-Enzymatic Inhibitors and Potential Anti-Allergic Drug-Like Compounds Discovered by Virtual and In Vitro Screening

المؤلفون: Pierre Martineau, Guillaume Laconde, Maria A. Miteva, Piona Dariavach, David Lagorce, Bruno O. Villoutreix

المساهمون: Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Le Ster, Yves, CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)

المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (6), pp.e21117. ⟨10.1371/journal.pone.0021117⟩
PLoS ONE, Vol 6, Iss 6, p e21117 (2011)

مصطلحات موضوعية: [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Drug Evaluation, Preclinical, Syk, lcsh:Medicine, Biology, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Drug Discovery, Anti-Allergic Agents, Animals, Syk Kinase, Mast Cells, Enzyme Inhibitors, lcsh:Science, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Molecular Structure, Drug discovery, Kinase, Allergy and Hypersensitivity, lcsh:R, Intracellular Signaling Peptides and Proteins, Computational Biology, Biological activity, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Protein-Tyrosine Kinases, Small molecule, In vitro, 3. Good health, Rats, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Biochemistry, 030220 oncology & carcinogenesis, [SDV.IMM]Life Sciences [q-bio]/Immunology, lcsh:Q, Tyrosine kinase, Research Article, Biotechnology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3125f2fa9b7f92f8f7768022cdb9942fTest
http://europepmc.org/articles/PMC3118801Test

7

DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening

المؤلفون: Tania Pencheva, Bruno O. Villoutreix, David Lagorce, Maria A. Miteva

المساهمون: Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre of Biomedical Engineering, Bulgarian Academy of Sciences (BAS), We would like to thank the Inserm institute, Paris Descartes University and Paris Diderot University for supports. TP thanks the 'Mairie de Paris' fellowship and the National Science Fund of Bulgaria, BMC, Ed.

المصدر: BMC Chemical Biology
BMC Chemical Biology, BioMed Central, 2009, 9 (1), pp.6. ⟨10.1186/1472-6769-9-6⟩
BMC Chemical Biology, Vol 9, Iss 1, p 6 (2009)

مصطلحات موضوعية: Computer science, In silico, Nanotechnology, Energy minimization, 01 natural sciences, Molecular mechanics, Computational science, lcsh:Biochemistry, 03 medical and health sciences, Drug Discovery, lcsh:QD415-436, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], 030304 developmental biology, 0303 health sciences, Virtual screening, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Drug discovery, Process (computing), [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Small molecule, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Software, Generator (mathematics)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa10968df03b3c22dbaed8f0f5dc908dTest
https://doi.org/10.1186/1472-6769-9-6Test

8

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

المؤلفون: Francesca De Giorgi, Naoual L Benali-Furet, François Ichas, Patrizia Paterlini-Bréchot, Rosario Rizzuto, Ludivine Houel, David Lagorce, Mounia Chami, Ralf Bartenschlager, Fabienne Vernejoul, Louis Buscail

المساهمون: CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Carcinogenèse Hépatique et Virologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Ferrara (UniFE), Signalisation et Mecanismes Moleculaires de l'Apoptose, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie et Pathologie Digestive, IFR 31 Louis Bugnard (IFR 31), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Molecular Virology, Universität Heidelberg [Heidelberg]

المصدر: Oncogene
Oncogene, Nature Publishing Group, 2005, 24 (31), pp.4921-33

مصطلحات موضوعية: Cancer Research, [SDV]Life Sciences [q-bio], aequorin, Hepacivirus, Endoplasmic Reticulum, Membrane Potentials, Mice, 0302 clinical medicine, LIVER-CANCER, Promoter Regions, Genetic, Endoplasmic Reticulum Chaperone BiP, Calcium signaling, 0303 health sciences, 3. Good health, Cell biology, Mitochondria, APOPTOSIS, cell death, Liver, 030220 oncology & carcinogenesis, HCV, ER stress, Liver cancer, Programmed cell death, HVC Core, chemistry.chemical_element, Mice, Transgenic, Calcium, Biology, Transfection, Models, Biological, 03 medical and health sciences, HCV core, Cell Line, Tumor, Genetics, In Situ Nick-End Labeling, Animals, Humans, Molecular Biology, 030304 developmental biology, Calcium metabolism, Apoptosis, Calcium signalling, Endoplasmic reticulum, Intracellular Membranes, Virology, CALCIUM SIGNALLING, Calcium ATPase, Mice, Inbred C57BL, chemistry, Unfolded protein response, endoplasmic reticulum, mitochondria

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328c4f3d8796110062c44fe0770ef41eTest
https://hal.archives-ouvertes.fr/hal-01259965Test

9

SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis

المؤلفون: Marc le Maire, Patrizia Paterlini-Bréchot, David Lagorce, Paolo Pinton, Christian Bréchot, Marisa Brini, Gérard Peaucellier, Devrim Gozuacik, Marie-Lyse Gougeon, Mounia Chami, Rosario Rizzuto, Pierre Falson, Hervé Lecoeur

المساهمون: Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Deleage, Gilbert

المصدر: Università degli Studi di Padova-IRIS
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2001, 153, pp.1301-1314
The Journal of Cell Biology

مصطلحات موضوعية: Adult, SERCA, RNA Splicing, Molecular Sequence Data, Gene Expression, chemistry.chemical_element, Calcium-Transporting ATPases, Biology, Calcium, Endoplasmic Reticulum, Protein Structure, Secondary, NO, Sarcoplasmic Reticulum Calcium-Transporting ATPases, 03 medical and health sciences, 0302 clinical medicine, Western blot, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Tumor Cells, Cultured, medicine, Humans, Protein Isoforms, Tissue Distribution, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, Cloning, Molecular, 030304 developmental biology, Calcium signaling, 0303 health sciences, calcium, splice variants, medicine.diagnostic_test, Endoplasmic reticulum, Apoptosis, SERCA1, Splice variants, apoptosis, Intracellular Membranes, Cell Biology, Molecular biology, Cell biology, Calcium ATPase, Cytosol, chemistry, 030220 oncology & carcinogenesis, Original Article, Dimerization, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df390fd4bb606b5ab2b90b2cdc6ea7b1Test
https://www.research.unipd.it/handle/11577/122797Test

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