Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin
| العنوان: | Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin |
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| المؤلفون: | József Balla, John W. Eaton, Viktória Jeney, György Balla |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2013 (2013) |
| بيانات النشر: | Hindawi Publishing Corporation, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Aging, Erythrocytes, Contusions, Review Article, Heme, Klinikai orvostudományok, Endocytosis, Biochemistry, Methemoglobin, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, Hemoglobins, 0302 clinical medicine, Animals, Humans, Globin, lcsh:QH573-671, 030304 developmental biology, 0303 health sciences, Autoxidation, lcsh:Cytology, Chemistry, Orvostudományok, Cell Biology, General Medicine, 3. Good health, Hemoglobin, CD163, Oxidation-Reduction, 030217 neurology & neurosurgery |
| الوصف: | Numerous disease states are associated with hemolysis or hemorrhage. Because red cells in the extravascular space tend to lyse quickly, hemoglobin (Hb) is released and is prone to autoxidation producing MetHb. Inorganic and organic peroxides may convert Hb and MetHb to higher oxidation states such as ferrylHb. FerrylHb is not a single chemical entity but is a mixture of globin- and porphyrin-centered radicals and covalently cross-linked Hb multimers. Oxidized Hb species are potent prooxidants caused mainly by heme release from oxidized Hb. Moreover, ferrylHb is a strong proinflammatory agonist that targets vascular endothelial cells. This proinflammatory effect of ferrylHb requires actin polymerization, is characterized by the upregulation of proinflammatory adhesion molecules, and is independent of heme release. Deleterious effects of native Hb are controlled by haptoglobin (Hp) that binds cell-free Hb avidly and facilitates its removal from circulation through the CD163 macrophage scavenger receptor-mediated endocytosis. Under circumstances of Hb oxidation, Hp can prevent heme release from MetHb, but unfortunately the Hp-mediated removal of Hb is severely compromised when Hb is structurally altered such as in ferrylHb allowing deleterious downstream reactions to occur even in the presence of Hp. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ea4cb3a481fd69ee64aef80c9b7134Test http://europepmc.org/articles/PMC3671564Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7ea4cb3a481fd69ee64aef80c9b7134 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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