Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health
| العنوان: | Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health |
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| المؤلفون: | David J. Edwards, Stephen Baker, Juliëtte A. Severin, Thomas R. Connor, Jonathan J. Wilksch, Kathryn E. Holt, Catrin E. Moore, Richard A. Strugnell, Paul N. Newton, Hanwei Cao, Mark B. Schultz, Martijn Mensink, David A. B. Dance, Trinh Tuyet Dao, Trung Vu Nguyen, Nguyen Thi Khanh Nhu, Kuntaman Kuntaman, Vien Le Minh, Ruth N. Zadoks, Adam Jenney, Kinh Van Nguyen, Constance Schultsz, Claire L. Gorrie, Sylvain Brisse, Nicholas R. Thomson, Li Yang Hsu, Chris A. Whitehouse, Heiman F. L. Wertheim |
| المساهمون: | Graduate School, AII - Amsterdam institute for Infection and Immunity, Global Health, Medical Microbiology & Infectious Diseases, Pediatric Surgery |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3574-E3581. National Academy of Sciences Proceedings of the National Academy of Sciences of the U.S.A., 112(27), E3574-E3581. National Academy of Sciences |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Klebsiella pneumoniae, Population Dynamics, Virulence, Genomics, Drug resistance, Klebsiella variicola, Genome, Microbiology, 03 medical and health sciences, Antibiotic resistance, Anti-Infective Agents, Bacterial Proteins, Species Specificity, SDG 3 - Good Health and Well-being, Drug Resistance, Multiple, Bacterial, Animals, Humans, Phylogeny, 030304 developmental biology, Cross Infection, 0303 health sciences, Multidisciplinary, biology, 030306 microbiology, Genetic Variation, Outbreak, Sequence Analysis, DNA, biology.organism_classification, Klebsiella Infections, 3. Good health, PNAS Plus, Genes, Bacterial, Public Health, Genome, Bacterial |
| الوصف: | Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more than 300 human and animal isolates spanning four continents. Our data provide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K. variicola). Further, for K. pneumoniae (KpI), the entity most frequently associated with human infection, we show the existence of >150 deeply branching lineages including numerous multidrug-resistant or hypervirulent clones. We show K. pneumoniae has a large accessory genome approaching 30,000 protein-coding genes, including a number of virulence functions that are significantly associated with invasive community-acquired disease in humans. In our dataset, antimicrobial resistance genes were common among human carriage isolates and hospital-acquired infections, which generally lacked the genes associated with invasive disease. The convergence of virulence and resistance genes potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-genome framework against which to track the emergence of such threats. |
| اللغة: | English |
| تدمد: | 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4db5023e28c5d45cc315ec6d6813dfTest https://pure.amc.nl/en/publications/genomic-analysis-of-diversity-population-structure-virulence-and-antimicrobial-resistance-in-klebsiella-pneumoniae-an-urgent-threat-to-public-healthTest(05c8c211-dec8-48c9-9201-77553357550b).html |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a4db5023e28c5d45cc315ec6d6813df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 |
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