Unravelling carbon metabolism in anaerobic cellulolytic bacteria
| العنوان: | Unravelling carbon metabolism in anaerobic cellulolytic bacteria |
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| المؤلفون: | Mickaël Desvaux |
| المساهمون: | Unité de Microbiologie (MIC), Institut National de la Recherche Agronomique (INRA) |
| المصدر: | Biotechnology Progress Biotechnology Progress, Wiley, 2006, 22 (5), pp.1229-1238. ⟨10.1021/bp060016e⟩ |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | CARBOHYDRATE-METABOLISM, [SDV]Life Sciences [q-bio], Carbohydrates, Cellulase, Cellobiose, CATALYTIC DOMAIN, CELLULOSE DEGRADATION, Clostridium cellulolyticum, Models, Biological, 03 medical and health sciences, chemistry.chemical_compound, Bioreactors, CLOSTRIDIUM-CELLULOLYTICUM, Cellodextrin, CRYSTAL-STRUCTURE, Biomass, NUCLEAR-MAGNETIC-RESONANCE, Cellulose, CELLULOLYTIC BACTERIA, 030304 developmental biology, Clostridium, 0303 health sciences, Fibrobacter succinogenes, FIBROBACTER-SUCCINOGENES S85, biology, 030306 microbiology, CELLULOSOME, STATE CONTINUOUS CULTURES, biology.organism_classification, BACTERIAL CELLULOSE, Carbon, Kinetics, chemistry, Biochemistry, Models, Chemical, Bacterial cellulose, biology.protein, ANAEROBIC METABOLISM, Clostridium thermocellum, ENDOGLUCANASE-A, CHEMICALLY-DEFINED MEDIUM, Biotechnology |
| الوصف: | International audience; Carbon metabolism in anaerobic cellulolytic bacteria has been investigated essentially in Clostridium thermocellum, Clostridium cellulolyticum, Fibrobacter succinogenes, Ruminococcus flaVefaciens, and Ruminococcus albus. While cellulose depolymerization into soluble sugars by various cellulases is undoubtedly the first step in bacterial metabolisation of cellulose, it is not the only one to consider. Among anaerobic cellulolytic bacteria, C. cellulolyticum has been investigated metabolically the most in the past few years. Summarizing metabolic flux analyses in continuous culture using either cellobiose (a soluble cellodextrin resulting from cellulose hydrolysis) or cellulose (an insoluble biopolymer), this review aims to stress the importance of the insoluble nature of a carbon source on bacterial metabolism. Furthermore, some general and specific traits of anaerobic cellulolytic bacteria trends, namely, the importance and benefits of (i) cellodextrins with degree of polymerization higher than 2, (ii) intracellular phosphorolytic cleavage, (iii) glycogen cycling on cell bioenergetics, and (iv) carbon overflows in regulation of carbon metabolism, as well as detrimental effects of (i) soluble sugars and (ii) acidic environment on bacterial growth. Future directions for improving bacterial cellulose degradation are discussed. |
| تدمد: | 8756-7938 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ecf1e6cf363b6bba4df0ed2b998a24Test https://pubmed.ncbi.nlm.nih.gov/17022659Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....83ecf1e6cf363b6bba4df0ed2b998a24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 87567938 |
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