نتائج البحث - "Type I interferon production"

1

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

المؤلفون: Marco Russo, Giovanni Capranico, Giulia Miglietta, Renée C. Duardo

المساهمون: Miglietta G., Russo M., Duardo R.C., Capranico G.

المصدر: Nucleic Acids Research

مصطلحات موضوعية: AcademicSubjects/SCI00010, Melanoma, Experimental, Micronuclei, Nucleotidyltransferase, Antineoplastic Agent, Mice, MCF-7 Cell, 0302 clinical medicine, Aminoquinoline, Interferon, Cytotoxic T cell, Picolinic Acids, Membrane Protein, Regulation of gene expression, 0303 health sciences, Fused-Ring Compounds, Nucleotidyltransferases, 030220 oncology & carcinogenesis, Aminoquinolines, MCF-7 Cells, Female, Signal transduction, Breast Neoplasm, Human, medicine.drug, Transcriptional Activation, Cytostatic Agent, Picolinic Acid, Antineoplastic Agents, Breast Neoplasms, Biology, Cell Line, 03 medical and health sciences, Chemical Biology and Nucleic Acid Chemistry, G-Quadruplexe, Genetics, medicine, Animals, Humans, Gene, Micronuclei, Chromosome-Defective, 030304 developmental biology, Innate immune system, Membrane Proteins, Interferon-beta, Type I interferon production, Cytostatic Agents, Fused-Ring Compound, Immunity, Innate, G-Quadruplexes, Cancer cell, Cancer research, Interferon Regulatory Factor-3

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b20edeb20e0351eeb8d735154aa2edTest
http://europepmc.org/articles/PMC8266585Test

2

Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route

المؤلفون: Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani

المصدر: Journal of Medicinal Chemistry. 64:6902-6923

مصطلحات موضوعية: Transplantation, Heterologous, Inflammation, 01 natural sciences, Phosphates, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Binding Sites, Innate immune system, Chemistry, Membrane Proteins, Type I interferon production, Acquired immune system, eye diseases, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Sting, Pyrimidines, Stimulator of interferon genes, Cancer research, Molecular Medicine, Administration, Intravenous, Cytokine secretion, Immunotherapy, Nucleotides, Cyclic, medicine.symptom, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442fTest
https://doi.org/10.1021/acs.jmedchem.1c00374Test

3

SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

المؤلفون: Sin-Yee Fung, Dong-Yan Jin, Huayue Lin, Man Lung Yeung, Kam-Leung Siu

المصدر: International Journal of Biological Sciences

مصطلحات موضوعية: medicine.medical_treatment, viruses, NSP5, Applied Microbiology and Biotechnology, 03 medical and health sciences, TANK-binding kinase 1, Interferon, Chlorocebus aethiops, medicine, Animals, Humans, Phosphorylation, skin and connective tissue diseases, Molecular Biology, Vero Cells, Ecology, Evolution, Behavior and Systematics, Coronavirus 3C Proteases, 030304 developmental biology, Cell Nucleus, 0303 health sciences, Protease, Chemistry, SARS-CoV-2, fungi, virus diseases, COVID-19, SARS-CoV, Cell Biology, biochemical phenomena, metabolism, and nutrition, IRF3, Type I interferon production, Cell biology, Protein Transport, type I interferons, Interferon Type I, Vero cell, Interferon Regulatory Factor-3, 3C-like protease, Interferon type I, Developmental Biology, medicine.drug, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd8d7f3983cacd8bd1d4e79b7e340fbTest
http://europepmc.org/articles/PMC8071772Test

4

The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms

المؤلفون: Victoria Lovins, Elin Movert, Esther Nobs, Christine Valfridsson, Fredric Carlsson, Julia Lienard

المصدر: Proceedings of the National Academy of Sciences. 117:1160-1166

مصطلحات موضوعية: 0303 health sciences, Multidisciplinary, Host cell cytosol, Innate immune system, biology, 030306 microbiology, Chemistry, Mutant, Mitochondrion, Type I interferon production, biology.organism_classification, Cell biology, 03 medical and health sciences, Cytosol, Secretion, Mycobacterium marinum, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::939ab839df337e899234c1380c34d17aTest
https://doi.org/10.1073/pnas.1911646117Test

5

SOCS-1 inhibition of type I interferon restrains Staphylococcus aureus skin host defense

المؤلفون: Sydney Castellanos, Nathan Klopfenstein, C. Henrique Serezani, Matthias Gunzer, Stephanie L. Brandt, Amondrea Blackman

المصدر: PLoS Pathogens, Vol 17, Iss 3, p e1009387 (2021)
PLoS Pathogens

مصطلحات موضوعية: Neutrophils, Staphylococcus, Biopsy, Medizin, Skin infection, medicine.disease_cause, Biochemistry, White Blood Cells, Mice, 0302 clinical medicine, Medical Conditions, Interferon, Animal Cells, Medicine and Health Sciences, Biology (General), Pathology and laboratory medicine, Skin, 0303 health sciences, Phagocytes, Effector, Medical microbiology, Infectious Diseases, Staphylococcus aureus, Interferon Type I, Staphylococcal Skin Infections, medicine.symptom, Pathogens, Cellular Types, medicine.drug, Research Article, Skin Infections, Methicillin-Resistant Staphylococcus aureus, QH301-705.5, Immune Cells, Immunology, Inflammation, Surgical and Invasive Medical Procedures, Dermatology, Biology, Skin Diseases, Microbiology, 03 medical and health sciences, Suppressor of Cytokine Signaling 1 Protein, Virology, Genetics, medicine, otorhinolaryngologic diseases, Animals, Molecular Biology, 030304 developmental biology, Innate immune system, Blood Cells, Biology and life sciences, Bacteria, Suppressor of cytokine signaling 1, Macrophages, Organisms, Proteins, Cell Biology, RC581-607, medicine.disease, Type I interferon production, Microbial pathogens, Mice, Inbred C57BL, Parasitology, Bacterial pathogens, Interferons, Immunologic diseases. Allergy, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6ca3bf6e5ea34f9af1269656212964Test
https://doaj.org/article/1779f18dc5e84c0fbac6cebf2508449dTest

6

E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase

المؤلفون: Wentao Zhang, Yanyu Guo, Lei Zhang, Jinhai Huang, Kun Tan, Chen Chen, Lilin Zhang, Jing He, Ruiqiao Li

المصدر: Virology. 532:55-68

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Swine, Ubiquitin-Protein Ligases, animal diseases, Suppressor of Cytokine Signaling Proteins, IκB kinase, Viral Nonstructural Proteins, Virus Replication, Cell Line, 03 medical and health sciences, Ubiquitin, Virology, Macrophages, Alveolar, Animals, Humans, Porcine respiratory and reproductive syndrome virus, 030304 developmental biology, 0303 health sciences, Innate immune system, biology, Protein Stability, Kinase, 030302 biochemistry & molecular biology, Ubiquitination, Porcine reproductive and respiratory syndrome virus, biology.organism_classification, Type I interferon production, I-kappa B Kinase, Ubiquitin ligase, Cell biology, IκBα, HEK293 Cells, Gene Expression Regulation, Host-Pathogen Interactions, Proteolysis, biology.protein, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf77ec1d110abb171f0a3a9d8fbae5Test
https://doi.org/10.1016/j.virol.2019.04.004Test

7

Inhibition of fowl adenovirus serotype 4 replication in Leghorn male hepatoma cells by SP600125 via blocking JNK MAPK pathway

المؤلفون: Jun Tang, Shijun J. Zheng, Xiaoqi Li, Hong Cao, Zhiyuan He, Mengjiao Fu, Xiang Chen, Yongqiang Wang

المصدر: Veterinary Microbiology. 228:45-52

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5bf3171beab39d77728c39f634f64fTest
https://doi.org/10.1016/j.vetmic.2018.11.014Test

8

Enterovirus D68 Protease 2A(pro) Targets TRAF3 To Subvert Host Innate Immune Responses

المؤلفون: Jinyan Cheng, Tao Wang, Wenjie Tan, Pang Zheng, Sihua Liu, Xianhuang Li, Jun Kang, Peiyuan Liu, Zhiyun Wang, Zhenwei Zhou

المصدر: J Virol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4892573ceeead7d8c51b287d78aaf073Test
https://europepmc.org/articles/PMC7925118Test/

9

Porcine haemagglutinating encephalomyelitis virus deactivates transcription factor IRF3 and limits type I interferon production

المؤلفون: Zi Li, Jing Zhang, Yungang Lan, Hongbin He, Huijun Lu, Junchao Shi, Rongyi Xu, Kui Zhao, Yawen Yang, Wenqi He, Jiyu Guan, Feng Gao

المصدر: Veterinary Microbiology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4345a5e6a142ff82a88d26826eb9a6Test

10

An Antiviral Drug Screening Platform with a FRET Biosensor for Measurement of Arenavirus Z Assembly

المؤلفون: Jiro Yasuda, Tatsuaki Mizutani, Yusuke Ohba, Shuzo Urata, Satoshi Mizuta

المصدر: Cell structure and function. 45(2)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23000e21533c48c4b9b3b0aa500a8d29Test
https://pubmed.ncbi.nlm.nih.gov/33191384Test

تنقيح النتائج