The different morphologies of yeast and filamentous fungi trigger distinct killing and feeding mechanisms in a fungivorous amoeba
| العنوان: | The different morphologies of yeast and filamentous fungi trigger distinct killing and feeding mechanisms in a fungivorous amoeba |
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| المؤلفون: | Falk Hillmann, Iuliia Ferling, Jakob L. Sprague, Silvia Radosa, Martin Westermann |
| المصدر: | Environmental Microbiology. 21:1809-1820 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | food.ingredient, Hypha, Hyphae, Hyphal tip, macromolecular substances, Microbiology, Amoeba (genus), Cell wall, 03 medical and health sciences, food, Phagocytosis, Cell Wall, Yeasts, Amoeba, Candida albicans, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, Innate immune system, biology, 030306 microbiology, fungi, Fungi, biology.organism_classification, Yeast, Spore |
| الوصف: | Size and diverse morphologies pose a primary challenge for phagocytes such as innate immune cells and predatory amoebae when encountering fungal prey. Although filamentous fungi can escape phagocytic killing by pure physical constraints, unicellular spores and yeasts can mask molecular surface patterns or arrest phagocytic processing. Here, we show that the fungivorous amoeba Protostelium aurantium was able to adjust its killing and feeding mechanisms to these different cell shapes. Yeast-like fungi from the major fungal groups of basidiomycetes and ascomycetes were readily internalized by phagocytosis, except for the human pathogen Candida albicans whose mannoprotein coat was essential to escape recognition by the amoeba. Dormant spores of the filamentous fungus Aspergillus fumigatus also remained unrecognized, but swelling and the onset of germination induced internalization and intracellular killing by the amoeba. Mature hyphae of A. fumigatus were mostly attacked from the hyphal tip and killed by an actin-mediated invasion of fungal filaments. Our results demonstrate that predatory pressure imposed by amoebae in natural environments selects for distinct survival strategies in yeast and filamentous fungi but commonly targets the fungal cell wall as a crucial molecular pattern associated to prey and pathogens. |
| تدمد: | 1462-2920 1462-2912 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9248d628b788ff46db9bee4887434933Test https://doi.org/10.1111/1462-2920.14588Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9248d628b788ff46db9bee4887434933 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14622920 14622912 |
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