التفاصيل البيبلوغرافية
العنوان:
Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity
المؤلفون:
Erik Volz , Verity Hill , John T. McCrone , Anna Price , David Jorgensen , Áine O’Toole , Joel Southgate , Robert Johnson , Ben Jackson , Fabricia F. Nascimento , Sara M. Rey , Samuel M. Nicholls , Rachel M. Colquhoun , Ana da Silva Filipe , James Shepherd , David J. Pascall , Rajiv Shah , Natasha Jesudason , Kathy Li , Ruth Jarrett , Nicole Pacchiarini , Matthew Bull , Lily Geidelberg , Igor Siveroni , Ian Goodfellow , Nicholas J. Loman , Oliver G. Pybus , David L. Robertson , Emma C. Thomson , Andrew Rambaut , Thomas R. Connor , Cherian Koshy , Emma Wise , Nick Cortes , Jessica Lynch , Stephen Kidd , Matilde Mori , Derek J. Fairley , Tanya Curran , James P. McKenna , Helen Adams , Christophe Fraser , Tanya Golubchik , David Bonsall , Catrin Moore , Sarah L. Caddy , Fahad A. Khokhar , Michelle Wantoch , Nicola Reynolds , Ben Warne , Joshua Maksimovic , Karla Spellman , Kathryn McCluggage , Michaela John , Robert Beer , Safiah Afifi , Sian Morgan , Angela Marchbank , Christine Kitchen , Huw Gulliver , Ian Merrick , Martyn Guest , Robert Munn , Trudy Workman , William Fuller , Catherine Bresner , Luke B. Snell , Themoula Charalampous , Gaia Nebbia , Rahul Batra , Jonathan Edgeworth , Samuel C. Robson , Angela Beckett , Katie F. Loveson , David M. Aanensen , Anthony P. Underwood , Corin A. Yeats , Khalil Abudahab , Ben E.W. Taylor , Mirko Menegazzo , Gemma Clark , Wendy Smith , Manjinder Khakh , Vicki M. Fleming , Michelle M. Lister , Hannah C. Howson-Wells , Louise Berry , Tim Boswell , Amelia Joseph , Iona Willingham , Paul Bird , Thomas Helmer , Karlie Fallon , Christopher Holmes , Julian Tang , Veena Raviprakash , Sharon Campbell , Nicola Sheriff , Matthew W. Loose , Nadine Holmes , Christopher Moore , Matthew Carlile , Victoria Wright , Fei Sang , Johnny Debebe , Francesc Coll , Adrian W. Signell , Gilberto Betancor , Harry D. Wilson , Theresa Feltwell , Charlotte J. Houldcroft , Sahar Eldirdiri , Anita Kenyon , Thomas Davis , Oliver Pybus , Louis du Plessis , Alex Zarebski , Jayna Raghwani , Moritz Kraemer , Sarah Francois , Stephen Attwood , Tetyana Vasylyeva , M. Estee Torok , William L. Hamilton , Ian G. Goodfellow , Grant Hall , Aminu S. Jahun , Yasmin Chaudhry , Myra Hosmillo , Malte L. Pinckert , Iliana Georgana , Anna Yakovleva , Luke W. Meredith , Samuel Moses , Hannah Lowe , Felicity Ryan , Chloe L. Fisher , Ali R. Awan , John Boyes , Judith Breuer , Kathryn Ann Harris , Julianne Rose Brown , Divya Shah , Laura Atkinson , Jack C.D. Lee , Adela Alcolea-Medina , Nathan Moore , Nicholas Cortes , Rebecca Williams , Michael R. Chapman , Lisa J. Levett , Judith Heaney , Darren L. Smith , Matthew Bashton , Gregory R. Young , John Allan , Joshua Loh , Paul A. Randell , Alison Cox , Pinglawathee Madona , Alison Holmes , Frances Bolt , James Price , Siddharth Mookerjee , Aileen Rowan , Graham P. Taylor , Manon Ragonnet-Cronin , Rob Johnson , Olivia Boyd , Erik M. Volz , Kirstyn Brunker , Katherine L. Smollett , Joshua Quick , Claire McMurray , Joanne Stockton , Sam Nicholls , Will Rowe , Radoslaw Poplawski , Rocio T. Martinez-Nunez , Jenifer Mason , Trevor I. Robinson , Elaine O'Toole , Joanne Watts , Cassie Breen , Angela Cowell , Catherine Ludden , Graciela Sluga , Nicholas W. Machin , Shazaad S.Y. Ahmad , Ryan P. George , Fenella Halstead , Venkat Sivaprakasam , James G. Shepherd , Patawee Asamaphan , Marc O. Niebel , Kathy K. Li , Rajiv N. Shah , Natasha G. Jesudason , Yasmin A. Parr , Lily Tong , Alice Broos , Daniel Mair , Jenna Nichols , Stephen N. Carmichael , Kyriaki Nomikou , Elihu Aranday-Cortes , Natasha Johnson , Igor Starinskij , Richard J. Orton , Joseph Hughes , Sreenu Vattipally , Joshua B. Singer , Antony D. Hale , Louissa R. Macfarlane-Smith , Katherine L. Harper , Yusri Taha , Brendan A.I. Payne , Shirelle Burton-Fanning , Sheila Waugh , Jennifer Collins , Gary Eltringham , Kate E. Templeton , Martin P. McHugh , Rebecca Dewar , Elizabeth Wastenge , Samir Dervisevic , Rachael Stanley , Reenesh Prakash , Claire Stuart , Ngozi Elumogo , Dheeraj K. Sethi , Emma J. Meader , Lindsay J. Coupland , Will Potter , Clive Graham , Edward Barton , Debra Padgett , Garren Scott , Emma Swindells , Jane Greenaway , Andrew Nelson , Wen C. Yew , Paola C. Resende Silva , Monique Andersson , Robert Shaw , Timothy Peto , Anita Justice , David Eyre , Derrick Crooke , Sarah Hoosdally , Tim J. Sloan , Nichola Duckworth , Sarah Walsh , Anoop J. Chauhan , Sharon Glaysher , Kelly Bicknell , Sarah Wyllie , Ethan Butcher , Scott Elliott , Allyson Lloyd , Robert Impey , Nick Levene , Lynn Monaghan , Declan T. Bradley , Elias Allara , Clare Pearson , Peter Muir , Ian B. Vipond , Richard Hopes , Hannah M. Pymont , Stephanie Hutchings , Martin D. Curran , Surendra Parmar , Angie Lackenby , Tamyo Mbisa , Steven Platt , Shahjahan Miah , David Bibby , Carmen Manso , Jonathan Hubb , Meera Chand , Gavin Dabrera , Mary Ramsay , Daniel Bradshaw , Alicia Thornton , Richard Myers , Ulf Schaefer , Natalie Groves , Eileen Gallagher , David Lee , David Williams , Nicholas Ellaby , Ian Harrison , Hassan Hartman , Nikos Manesis , Vineet Patel , Chloe Bishop , Vicki Chalker , Husam Osman , Andrew Bosworth , Esther Robinson , Matthew T.G. Holden , Sharif Shaaban , Alec Birchley , Alexander Adams , Alisha Davies , Amy Gaskin , Amy Plimmer , Bree Gatica-Wilcox , Caoimhe McKerr , Catherine Moore , Chris Williams , David Heyburn , Elen De Lacy , Ember Hilvers , Fatima Downing , Giri Shankar , Hannah Jones , Hibo Asad , Jason Coombes , Joanne Watkins , Johnathan M. Evans , Laia Fina , Laura Gifford , Lauren Gilbert , Lee Graham , Malorie Perry , Mari Morgan , Michelle Cronin , Noel Craine , Rachel Jones , Robin Howe , Sally Corden , Sara Rey , Sara Kumziene-Summerhayes , Sarah Taylor , Simon Cottrell , Sophie Jones , Sue Edwards , Justin O’Grady , Andrew J. Page , John Wain , Mark A. Webber , Alison E. Mather , David J. Baker , Steven Rudder , Muhammad Yasir , Nicholas M. Thomson , Alp Aydin , Ana P. Tedim , Gemma L. Kay , Alexander J. Trotter , Rachel A.J. Gilroy , Nabil-Fareed Alikhan , Leonardo de Oliveira Martins , Thanh Le-Viet , Lizzie Meadows , Anastasia Kolyva , Maria Diaz , Andrew Bell , Ana Victoria Gutierrez , Ian G. Charles , Evelien M. Adriaenssens , Robert A. Kingsley , Anna Casey , David A. Simpson , Zoltan Molnar , Thomas Thompson , Erwan Acheson , Jane A.H. Masoli , Bridget A. Knight , Andrew Hattersley , Sian Ellard , Cressida Auckland , Tabitha W. Mahungu , Dianne Irish-Tavares , Tanzina Haque , Yann Bourgeois , Garry P. Scarlett , David G. Partridge , Mohammad Raza , Cariad Evans , Kate Johnson , Steven Liggett , Paul Baker , Sarah Essex , Ronan A. Lyons , Laura G. Caller , Sergi Castellano , Rachel J. Williams , Mark Kristiansen , Sunando Roy , Charlotte A. Williams , Patricia L. Dyal , Helena J. Tutill , Yasmin N. Panchbhaya , Leysa M. Forrest , Paola Niola , Jacqueline Findlay , Tony T. Brooks , Artemis Gavriil , Lamia Mestek-Boukhibar , Sam Weeks , Sarojini Pandey , Lisa Berry , Katie Jones , Alex Richter , Andrew Beggs , Colin P. Smith , Giselda Bucca , Andrew R. Hesketh , Ewan M. Harrison , Sharon J. Peacock , Sophie Palmer , Carol M. Churcher , Katherine L. Bellis , Sophia T. Girgis , Plamena Naydenova , Beth Blane , Sushmita Sridhar , Chris Ruis , Sally Forrest , Claire Cormie , Harmeet K. Gill , Joana Dias , Ellen E. Higginson , Mailis Maes , Jamie Young , Leanne M. Kermack , Nazreen F. Hadjirin , Dinesh Aggarwal , Luke Griffith , Tracey Swingler , Rose K. Davidson , Thomas Williams , Carlos E. Balcazar , Michael D. Gallagher , Áine O'Toole , Stefan Rooke , Rachel Colquhoun , Jordan Ashworth , J.T. McCrone , Emily Scher , Xiaoyu Yu , Kathleen A. Williamson , Thomas D. Stanton , Stephen L. Michell , Claire M. Bewshea , Ben Temperton , Michelle L. Michelsen , Joanna Warwick-Dugdale , Robin Manley , Audrey Farbos , James W. Harrison , Christine M. Sambles , David J. Studholme , Aaron R. Jeffries , Alistair C. Darby , Julian A. Hiscox , Steve Paterson , Miren Iturriza-Gomara , Kathryn A. Jackson , Anita O. Lucaci , Edith E. Vamos , Margaret Hughes , Lucille Rainbow , Richard Eccles , Charlotte Nelson , Mark Whitehead , Lance Turtle , Sam T. Haldenby , Richard Gregory , Matthew Gemmell , Dominic Kwiatkowski , Thushan I. de Silva , Nikki Smith , Adrienn Angyal , Benjamin B. Lindsey , Danielle C. Groves , Luke R. Green , Dennis Wang , Timothy M. Freeman , Matthew D. Parker , Alexander J. Keeley , Paul J. Parsons , Rachel M. Tucker , Rebecca Brown , Matthew Wyles , Chrystala Constantinidou , Meera Unnikrishnan , Sascha Ott , Jeffrey K.J. Cheng , Hannah E. Bridgewater , Lucy R. Frost , Grace Taylor-Joyce , Richard Stark , Laura Baxter , Mohammad T. Alam , Paul E. Brown , Patrick C. McClure , Joseph G. Chappell , Theocharis Tsoleridis , Jonathan Ball , Dimitris Grammatopoulos , David Buck , John A. Todd , Angie Green , Amy Trebes , George MacIntyre-Cockett , Mariateresa de Cesare , Cordelia Langford , Alex Alderton , Roberto Amato , Sonia Goncalves , David K. Jackson , Ian Johnston , John Sillitoe , Steve Palmer , Mara Lawniczak , Matt Berriman , John Danesh , Rich Livett , Lesley Shirley , Ben Farr , Mike Quail , Scott Thurston , Naomi Park , Emma Betteridge , Danni Weldon , Scott Goodwin , Rachel Nelson , Charlotte Beaver , Laura Letchford , David A. Jackson , Luke Foulser , Liz McMinn , Liam Prestwood , Sally Kay , Leanne Kane , Matthew J. Dorman , Inigo Martincorena , Christoph Puethe , Jon-Paul Keatley , Gerry Tonkin-Hill , Christen Smith , Dorota Jamrozy , Mathew A. Beale , Minal Patel , Cristina Ariani , Michael Spencer-Chapman , Eleanor Drury , Stephanie Lo , Shavanthi Rajatileka , Carol Scott , Keith James , Sarah K. Buddenborg , Duncan J. Berger , Gaurang Patel , Maria V. Garcia-Casado , Thomas Dibling , Samantha McGuigan , Hazel A. Rogers , Adam D. Hunter , Emily Souster , Alexandra S. Neaverson
المساهمون:
Medical Research Council (MRC), Pascall, David [0000-0002-7543-0860], Apollo - University of Cambridge Repository
المصدر:
75.e11https://doi.org/10.1016/j.cell.2020.11.020Test https://doi.org/10.1016/j.cell.2020.11.020Test
بيانات النشر:
Elsevier (Cell Press), 2021.
سنة النشر:
2021
مصطلحات موضوعية:
Genome , Genetic analysis , 0302 clinical medicine , Clade , 11 Medical and Health Sciences , Genetics , 0303 health sciences , education.field_of_study , Phylogenetic tree , Virulence , C500 , COG-UK Consortium , C700 , Transmissibility (vibration) , 3. Good health , founder effect , Spike Glycoprotein, Coronavirus , epidemiology , Viral load , Population , Glycine , B100 , Genomics , Genome, Viral , Biology , Article , General Biochemistry, Genetics and Molecular Biology , 03 medical and health sciences , evolution , Humans , education , 030304 developmental biology , Aspartic Acid , Whole Genome Sequencing , Biochemistry, Genetics and Molecular Biology(all) , SARS-CoV-2 , COVID-19 , spike , The COVID-19 Genomics UK Consortium , A300 , 06 Biological Sciences , United Kingdom , Amino Acid Substitution , Evolutionary biology , Mutation , Biological dispersal , 030217 neurology & neurosurgery , Founder effect , Developmental Biology
الوصف:
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
وصف الملف:
application/pdf
اللغة:
English
تدمد:
0092-8674
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39323207c331e214a06a2be9bf69912Test https://eprints.gla.ac.uk/225771/1/225771.pdfTest
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....d39323207c331e214a06a2be9bf69912
قاعدة البيانات:
OpenAIRE
