نتائج البحث - "Type I interferon production"

1

Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route

المؤلفون: Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani

المصدر: Journal of Medicinal Chemistry. 64:6902-6923

مصطلحات موضوعية: Transplantation, Heterologous, Inflammation, 01 natural sciences, Phosphates, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Binding Sites, Innate immune system, Chemistry, Membrane Proteins, Type I interferon production, Acquired immune system, eye diseases, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Sting, Pyrimidines, Stimulator of interferon genes, Cancer research, Molecular Medicine, Administration, Intravenous, Cytokine secretion, Immunotherapy, Nucleotides, Cyclic, medicine.symptom, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442fTest
https://doi.org/10.1021/acs.jmedchem.1c00374Test

2

SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

المؤلفون: Sin-Yee Fung, Dong-Yan Jin, Huayue Lin, Man Lung Yeung, Kam-Leung Siu

المصدر: International Journal of Biological Sciences

مصطلحات موضوعية: medicine.medical_treatment, viruses, NSP5, Applied Microbiology and Biotechnology, 03 medical and health sciences, TANK-binding kinase 1, Interferon, Chlorocebus aethiops, medicine, Animals, Humans, Phosphorylation, skin and connective tissue diseases, Molecular Biology, Vero Cells, Ecology, Evolution, Behavior and Systematics, Coronavirus 3C Proteases, 030304 developmental biology, Cell Nucleus, 0303 health sciences, Protease, Chemistry, SARS-CoV-2, fungi, virus diseases, COVID-19, SARS-CoV, Cell Biology, biochemical phenomena, metabolism, and nutrition, IRF3, Type I interferon production, Cell biology, Protein Transport, type I interferons, Interferon Type I, Vero cell, Interferon Regulatory Factor-3, 3C-like protease, Interferon type I, Developmental Biology, medicine.drug, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd8d7f3983cacd8bd1d4e79b7e340fbTest
http://europepmc.org/articles/PMC8071772Test

3

The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms

المؤلفون: Victoria Lovins, Elin Movert, Esther Nobs, Christine Valfridsson, Fredric Carlsson, Julia Lienard

المصدر: Proceedings of the National Academy of Sciences. 117:1160-1166

مصطلحات موضوعية: 0303 health sciences, Multidisciplinary, Host cell cytosol, Innate immune system, biology, 030306 microbiology, Chemistry, Mutant, Mitochondrion, Type I interferon production, biology.organism_classification, Cell biology, 03 medical and health sciences, Cytosol, Secretion, Mycobacterium marinum, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::939ab839df337e899234c1380c34d17aTest
https://doi.org/10.1073/pnas.1911646117Test

4

An Antiviral Drug Screening Platform with a FRET Biosensor for Measurement of Arenavirus Z Assembly

المؤلفون: Jiro Yasuda, Tatsuaki Mizutani, Yusuke Ohba, Shuzo Urata, Satoshi Mizuta

المصدر: Cell structure and function. 45(2)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23000e21533c48c4b9b3b0aa500a8d29Test
https://pubmed.ncbi.nlm.nih.gov/33191384Test

5

Regulation and Consequences of cGAS Activation by Self-DNA

المؤلفون: Hironori Funabiki, Christian Zierhut

المصدر: Trends Cell Biol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0a8ee2ef639bb9d419d3f4307c9e7cTest
https://pubmed.ncbi.nlm.nih.gov/32546434Test

6

Marek's Disease Virus RLORF4 Inhibits Type I Interferon Production by Antagonizing NF-κB Activation

المؤلفون: Yongzhen Liu, Dan Luo, Kai Li, Li Gao, Xiaomei Wang, Hongyu Cui, Yu Zhang, Xiaole Qi, Zengkun Xu, Yulong Gao, Yanping Zhang, Changjun Liu

المصدر: Journal of virology. 93(18)

مصطلحات موضوعية: Cellular immunity, animal structures, viruses, Immunology, Chick Embryo, Virus Replication, Microbiology, Virus, 03 medical and health sciences, chemistry.chemical_compound, Viral Proteins, Interferon, Virology, medicine, Marek Disease, Animals, Humans, Herpesvirus 2, Gallid, 030304 developmental biology, 0303 health sciences, Marek's disease, biology, 030302 biochemistry & molecular biology, NF-kappa B, DNA virus, NF-κB, Interferon-beta, Type I interferon production, biology.organism_classification, Immunity, Innate, Cell biology, Virus-Cell Interactions, HEK293 Cells, chemistry, Insect Science, Stimulator of interferon genes, DNA, Viral, Chickens, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d03e56ac76ec2f08d0cdcee1788408Test
https://pubmed.ncbi.nlm.nih.gov/31243133Test

7

Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing

المؤلفون: Yong Cheng, Jeffery S. Schorey

المصدر: EMBO reports. 20

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0ac2fa400b536d10d486ac8882fd2ee6Test
https://doi.org/10.15252/embr.201846613Test

8

Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection

المؤلفون: Genhong Cheng, Brian Zarnegar, Andrea K. Perry, Gustavo A. Miranda, Supriya K. Saha, Jeff F. Miller, Tadatsugu Taniguchi, Bidong O. Nguyen, Kevin W. Bruhn, Sagar A. Vaidya, Ryan M. O'Connell, Timothy F. Lane

المصدر: The Journal of Experimental Medicine

مصطلحات موضوعية: Lipopolysaccharide, IFN target gene, Apoptosis, IFNAR, Receptor, Interferon alpha-beta, medicine.disease_cause, Polymerase Chain Reaction, Mice, chemistry.chemical_compound, 0302 clinical medicine, Immunology and Allergy, Listeriosis, Receptor, Receptors, Interferon, 0303 health sciences, intracellular bacteria, 3. Good health, DNA-Binding Proteins, medicine.anatomical_structure, Liver, Interferon Type I, Disease Susceptibility, medicine.drug, Immunoblotting, Immunology, Enzyme-Linked Immunosorbent Assay, Spleen, Biology, Article, 03 medical and health sciences, Listeria monocytogenes, In Situ Nick-End Labeling, medicine, Animals, DNA Primers, 030304 developmental biology, Macrophages, Intracellular parasite, Membrane Proteins, IRF3, Type I interferon production, Virology, Mice, Inbred C57BL, chemistry, Interferon Regulatory Factor-3, Interferon type I, Transcription Factors, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b61ffe7a6364dfbeb22f54c33041e33Test
https://doi.org/10.1084/jem.20040712Test

9

Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus

المؤلفون: Timothy B. Niewold, Meena Shrivastav

المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 4 (2013)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3a5f790869aabc7bbebca036353b45Test
https://doi.org/10.3389/fimmu.2013.00319Test

10

The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses

المؤلفون: Jennifer P. Wang, Daniel H. Libraty, Rachel Madera

المصدر: PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e29412 (2011)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Time Factors, Anatomy and Physiology, medicine.medical_treatment, Interleukin-1beta, lcsh:Medicine, Adaptive Immunity, chemistry.chemical_compound, Mice, 0302 clinical medicine, Interferon, Interleukin-1alpha, Immune Physiology, Molecular Cell Biology, lcsh:Science, Immune Response, 0303 health sciences, Multidisciplinary, T Cells, Vaccination, Pattern recognition receptor, Imidazoles, Innate Immunity, 3. Good health, Cell biology, Interferon Type I, Cytokines, Medicine, Signal transduction, Resiquimod, Adjuvant, Cell Division, medicine.drug, Signal Transduction, Research Article, Immune Cells, Immunology, Biology, Immunomodulation, 03 medical and health sciences, Immune system, Adjuvants, Immunologic, Vaccine Development, medicine, Animals, RNA, Messenger, 030304 developmental biology, Cytokinesis, lcsh:R, Immunity, Dendritic Cells, Th1 Cells, Molecular Development, Type I interferon production, Poly I-C, chemistry, Immune System, Myeloid Differentiation Factor 88, RNA, lcsh:Q, Clinical Immunology, Interferon type I, 030215 immunology, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaa786fc5fb3afd58f1e99e8a19c603Test
https://pubmed.ncbi.nlm.nih.gov/22206014Test

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