Beneficial molecular adaptations in BRCA-mutation carriers by combined HIT/HIRT intervention: results from a pilot study
| العنوان: | Beneficial molecular adaptations in BRCA-mutation carriers by combined HIT/HIRT intervention: results from a pilot study |
|---|---|
| المؤلفون: | Stephanie Otto, Uwe Schumann, Florian Ebner, Jürgen M. Steinacker, Daniel A. Bizjak, Jens Huober, Sebastian Schulz, Johannes Kirsten, Wolfgang Janni, Elena Leinert |
| المصدر: | Cancers Volume 12 Issue 6 |
| بيانات النشر: | Universität Ulm, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Breast neoplasms, Genetics, Strength training, Genes, BRCA1, Genetic predisposition to disease, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, BRCA1 mutation, Downregulation and upregulation, Internal medicine, Oxidativer Stress, Gene expression, BRCA protein/gene expression, Brustkrebs, Medicine, ddc:610, Gen BRCA 1, Muscle biopsy, medicine.diagnostic_test, business.industry, BRCA mutation, Skeletal muscle, combination HIT/HIRT program, 030229 sport sciences, Biomarker, BRCA1, medicine.anatomical_structure, Endocrinology, Oncology, Oxidative stress, 030220 oncology & carcinogenesis, Increased inflammatory response, business, molecular adaptations, anti-oxidative stress/inflammatory response, Biomarkers |
| الوصف: | Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined the influence of regular exercise in human BRCA mutation carriers on their BRCA1 gene/protein expression and inflammatory/oxidative response. Sixteen BRCA-mutation carriers were assigned to an intervention (IG) or control group (CG). IG received a combination of high-intensity interval endurance (HIT) and strength training (HIRT) for six weeks, whereas CG received a low-intensity activity program. Before (T0) and at the end of the intervention (T1), muscle biopsy, physiological performance, blood withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, peak oxygen capacity (VO2peak) and 1-repetition maximum (1-RM) at six different training machines. VO2peak and 1-RM of IG were increased at T1 compared to T0, whereas CG performance, physiological and molecular parameters remained unchanged. IG showed increased BRCA1 protein concentration as well as anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory and oxidative damage did not differ between time points. Combined HIT/HIRT increases aerobic and strength performance of BRCA-mutation carriers with up regulated BRCA1 protein expression and improved anti-oxidative status without showing an increased inflammatory response. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b30cebd4ca7dccac8778387356f77eeTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b30cebd4ca7dccac8778387356f77ee |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |