Efficacy of levetiracetam for neonatal seizures in preterm infants
| العنوان: | Efficacy of levetiracetam for neonatal seizures in preterm infants |
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| المؤلفون: | In Goo Lee, Chung Joon Moon, In Kyung Sung, Young-Ah Youn, Ji Yoon Han |
| المصدر: | BMC Pediatrics, Vol 18, Iss 1, Pp 1-6 (2018) BMC Pediatrics |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Levetiracetam, Birth weight, Gestational Age, Infant, Premature, Diseases, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Seizures, 030225 pediatrics, medicine, Birth Weight, Humans, Adverse effect, Retrospective Studies, Maintenance dose, business.industry, Infant, Newborn, lcsh:RJ1-570, Brain, Gestational age, Preterm infants, Retrospective cohort study, lcsh:Pediatrics, Neonatal seizures, Magnetic Resonance Imaging, Phenobarbital, Pediatrics, Perinatology and Child Health, Anticonvulsants, Female, business, Infant, Premature, 030217 neurology & neurosurgery, Research Article, medicine.drug |
| الوصف: | Background Neonatal seizures remain a significant clinical problem, and therapeutic options are still not diverse with limited efficacy. Levetiracetam (LEV) is a relatively new and wide spectrum anti-seizure medication with favorable pharmacokinetics and safety profile. In the recent decades, LEV has been increasingly used for the treatment of neonatal seizures. The aim of this study was to describe the experience of using LEV as the first line anti-seizure medication for preterm infants. Methods A retrospective analysis of 37 preterm infants who were treated with LEV as the first-line anti-seizure medication was performed. Results Mean gestational age of the 37 preterm infants was 31.5 ± 1.9 weeks (range, 26 to 36+ 6 weeks). Twenty-one infants (57%) were seizure-free while given LEV at the end of the first week, and no additional anti-seizure medication was required. Loading doses of LEV ranged from 40 to 60 mg/kg (mean 56 mg/kg) and the maintenance dose ranged from 20 to 30 mg/kg (mean 23 mg/kg). No adverse effect was observed. Conclusions Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants. Prospective double blind controlled studies are needed in the future. |
| اللغة: | English |
| تدمد: | 1471-2431 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b770497760faf615e36e7df78030c8Test http://link.springer.com/article/10.1186/s12887-018-1103-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....13b770497760faf615e36e7df78030c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712431 |
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