نتائج البحث - "Primary bone"

1

Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature

المؤلفون: Wen-Hao Wu, Hai-Jun Huang, Meijuan Chen, Wei Zheng, Yi-Cheng Huang, Qiaoqiao Yin, Hongying Pan, Tian-Chen Hui, Rong Yan, Qingqing Wu

المصدر: World Journal of Clinical Cases

الوصف: BACKGROUND Primary bone lymphoma (PBL) is an uncommon extranodal disease that represents approximately 1%-3% of lymphomas. Anaplastic lymphoma kinase (ALK) positive anaplastic large-cell lymphoma (ALCL) is an extremely rare type of PBL. The aim of this report is describe the symptoms, diagnosis, and treatment of primary bone ALK-positive ALCL. CASE SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 mo. After extensive evaluation, positron emission tomography-computed tomography (CT) examination showed multiple osteolytic bone lesions without other sites lesions. CT-guided biopsy of the T10 vertebral body was performed, and the pathology results showed that neoplastic cells were positive for ALK-1, CD30, and CD3. A diagnosis of primary bone ALK positive ALCL was ultimately made. The patient was in partial response after four cycle soft cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy, and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of therapy. CONCLUSION Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement, and lymphoma should be considered in the differential diagnosis of primary bone lesions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723306de7178f54c84347d898fd32ba5Test
https://doi.org/10.12998/wjcc.v9.i14.3403Test

2

Primary liposarcoma of the fibular head: A rare location for a rare tumor: A case report

المؤلفون: Y. Aznague, M.A. Benhima, H. Saidi, B. Boanimbek, I. Abkari, A. El Moula

المصدر: International Journal of Surgery Case Reports

الوصف: Highlights • This article aims to present a rare tumor due to its nature and location. Which will allow professionals a rapid recognition and adequate management of this type of tumor. • It also presents the peculiarities of histological diagnosis. • Our work talks about the specificity of the management of fibular head tumors. • Finally it deals with the stability of the knee post-surgery.
Introduction Primary bone liposarcoma are extremely rare tumors and their location in the fibular head is exceptional. Case report A 19 year-old patient with a pain on the lateral of the proximal leg. The X-ray found an osteolytic lesion; MRI of the knee revealed a proximal epiphyseal-metaphyseal lesion process of the right fibula contours with cortical lysis and local medullary damage. The pathological study, follow by the immunohistochemical exam and the FISH concluded in an amplification of MDM2 (Murine double minute 2) confirming the presence of a liposarcoma. Discussion The primary bone localization of liposarcomas remains rare. Their localization at the level of the fibular head is exceptional. The proximal fibula is mainly affected by benign tumors, in particular giant cell. Malignant tumors localized to the head of the fibula as well as aggressive benign tumors most often require en bloc resection. Conclusion Although rare, primary liposarcomas can localize to the head of the fibula. It is necessary to establish a clinical, radiological and histological diagnosis for adequate management.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b800bdf1dc66904531676c8450f70efTest
https://doi.org/10.1016/j.ijscr.2020.12.026Test

3

Resection arthrodesis and osteoarticular allografts reconstruction after resection of primary bone tumors around the knee: Long‐term clinical outcomes and prognostic factors for failure of biological reconstruction

المؤلفون: Winai Sirichativapee, Weerachai Kosuwon, Taweechok Wisanuyotin, Permsak Paholpak

المصدر: Asia-Pacific Journal of Clinical Oncology. 18:240-248

الوصف: Aim The biological reconstruction of the knee with osteoarticular allografts and resection arthrodesis have been reported but there has not yet been a direct comparison between both these procedures. This study aimed to identify the prognostic factors that influence failure of biological reconstruction and compared the results between both procedures. Methods Between 1994 and 2017, we performed 92 limb-sparing procedures using resection arthrodesis (n = 53) and osteoarticular allograft reconstruction (n = 39) for the management of primary bone tumors around the knee. The minimum follow-up time was 2 years in both groups. Results The failure rate of reconstruction in the osteoarticular allograft and resection arthrodesis group was 48.7% and 39.6%, respectively (p = 0.75). The mean MSTS score in the osteoarticular allograft and resection arthrodesis group was 23.7 and 21.8, respectively (p = 0.01). The significant risk factor for failure after biological reconstruction was the administration of chemotherapy (p = 0.001; HR = 3.39; 95% CI, 1.60-7.17). Conclusion Patients who underwent osteoarticular allograft had a better functional outcome than those who underwent resection arthrodesis reconstruction, but clinical outcomes between the groups were comparable. Chemotherapy is a significant adverse prognostic factor for failure of biological reconstruction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a59907c643c8a3d2128e31b96efa2dTest
https://doi.org/10.1111/ajco.13607Test

4

Bone tumors distribution in diagnostic and excisional biopsies

المؤلفون: Mutaz Ahmad Ghabashneh, Ahmad Khaled Almigdad, Ola Mohammad Alwaqfi, Hamzeh Ahmad Alfqaha, Bara’ Zaid Dagher

المصدر: Journal of Musculoskeletal Surgery and Research. 5:159-168

مصطلحات موضوعية: 0301 basic medicine, Osteochondroma, medicine.medical_specialty, business.industry, Bone pathology, medicine.disease, Malignancy, Benign tumor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Primary bone, 030220 oncology & carcinogenesis, medicine, Enchondroma, Osteosarcoma, Femur, Radiology, business

الوصف: Objectives: Bone tumors are uncommon. Nevertheless, bone is a common site for metastasis. Due to limited data regarding bone tumors in Jordan, this study aims to understand better bone tumor epidemiology and distribution in the Jordanian population. Methods: A part of a retrospective, single-center study, all biopsy reports confirming the diagnosis of a bone tumor between January 2017 and December 2019 were abstracted from Princess Iman Research Center records. The patients’ age, gender, anatomical location, and histopathological type of the tumors were obtained and analyzed. Results: Two hundred eighty-four diagnostic and excisional biopsies were reviewed. Most of the patients (60.2%) were males. The mean age for the patients was 26.74(±16.29) years. Malignant bone tumors were diagnosed in 15.5%. The femur was the most common site of biopsy diagnosed tumor followed by the tibia. Osteochondroma was the most commonly diagnosed benign tumor and accounted for 39.4%, followed by aneurysmal bone cysts (14.8%), and enchondroma (10.2%). The metastatic bone tumors were the most frequent malignant bone pathology (6.7%), while osteosarcoma was the most common primary sarcoma, diagnosed in 5.6% of the sample. Increasing age, pelvic, and spine location of bone tumors were found to be significantly associated with malignancy. Conclusion: In our 284 samples, osteochondromas were the most commonly diagnosed tumors (39.4%), followed by aneurysmal bone cysts (14.8%), and enchondromas (10.2%). Metastatic tumors were the most common malignant bone pathologies, while osteosarcomas were the most common primary bone sarcomas. Femur and tibia were the most common tumor-located sites. Breast and lung deposition were the most common metastasis primaries. Additionally, increasing age, pelvic, and spine-located bone tumors were significantly associated with malignancy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8eb8c74f6d0557f9344ac69992a2590aTest
https://doi.org/10.25259/jmsr_49_2021Test

5

Distal Tibial Reconstruction in the Management of Primary Bone Tumors in Children and Adolescents

المؤلفون: Bartosz Pachuta, Katarzyna Bilska, Carlos Rodriguez-Galindo, Anna Raciborska, Iwona Malesza

المصدر: Foot & Ankle International. 42:1447-1453

الوصف: Background: Distal tibial primary bone tumors are rare, and options for limb salvage surgery are limited and challenging. Importantly, local control has shown to be crucial and necessary for cure, and radical surgery is one of the most important components of therapy for some bone sarcomas. We investigated the feasibility and functional and oncological outcomes of distal tibial reconstruction using endoprosthesis in children with malignant bone tumors. Methods: Fourteen patients (median age 13.6 years) with primary bone tumors (4 Ewing sarcoma [ES], 10 osteosarcoma) of the distal tibiae were treated during 2013-2019. All patients had reconstruction using a modular (13 patients) or expandable custom-made titanium bone replacement system (1 patient). All patients received chemotherapy before and after surgery. Results: Twelve patients (85.7%) are alive with a median follow-up 20 months from diagnosis. Five-year estimates of event-free survival and overall survival were 60.6% and 76.4%, respectively. Three patients had postoperative complications requiring second surgery. Maximum dorsiflexion and plantar flexion of the foot were 20 degrees (range 0-20 degrees) and 20 degrees (range 5-20 degrees), respectively. Conclusion: For select distal tibial sarcomas, after neoadjuvant chemotherapy pretreatment and radical resection, reconstruction using an endoprosthesis as a radical surgery provides an option was associated with a low rate of short-term local complications and relatively good early function. Level of Evidence: Level IV, therapeutic study.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240739768b33b95828ff738443dad5f7Test
https://doi.org/10.1177/10711007211012690Test

6

The ‘other’ bone sarcomas in Japan: a retrospective study of primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, using data from the Bone Tumuor Registry in Japan

المؤلفون: Yutaka Nishimoto, Akira Kawai, Akihito Nagano, Haruhiko Akiyama, Masanori Tsugita

المصدر: Japanese Journal of Clinical Oncology. 51:1430-1436

الوصف: Background To date, no standard treatments for primary bone sarcomas other than those for osteosarcoma, Ewing sarcoma and chondrosarcoma have been developed. Methods The clinical characteristics and prognostic factors of 330 patients with primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, listed in a nationwide tumour registry (Bone and Soft Tissue Tumor Registry in Japan) were investigated. The effects of adjuvant chemotherapy were determined by comparing the outcomes of patients with non-metastatic bone tumours who received surgery plus chemotherapy with those of patients who underwent surgery alone. Results The most common diagnosis was undifferentiated high-grade pleomorphic sarcoma. Axial site tumours (47.8%) and distant metastases at presentation (24.5%) were frequent. The 5-year overall and progression-free survival rates were 44.9 and 39.9%, respectively. Prognostic factor analysis identified surgery as an independent predictor of overall survival, and distant metastases at presentation was significant and independent predictor of both overall and progression-free survival. No significant difference in outcome was observed between patients treated with surgery alone and those treated with surgery plus chemotherapy (P = 0.71). Conclusions Patients with bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma without metastasis at presentation have a relatively good prognosis with definitive surgery; however, the benefit of adjuvant chemotherapy is unclear.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651fbe0e88b55590cc220e6f5ffc8659Test
https://doi.org/10.1093/jjco/hyab090Test

7

Effects of different vardenafil doses on bone healing in a rat fracture model

المؤلفون: Mehmet Akif Güleç, Tolgahan Atçı, Derya Karabulut, Abdurrahman Acar, Elif Yaprak Sarac, Hakan Özbay, Mustafa Fatih Daşcı, Ender Alagöz

المصدر: Joint Diseases and Related Surgery

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Urology, Nitric Oxide Synthase Type II, Bone healing, Tadalafil, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta3, Vardenafil Dihydrochloride, Bone Density, medicine, Animals, Orthopedics and Sports Medicine, Femur, rat, vardenafil, Bony Callus, Saline, Bone mineral, Fracture Healing, 030222 orthopedics, Phosphodiesterase-5 Inhibitor, business.industry, Rehabilitation, NF-kappa B, Beta, Bone fracture, X-Ray Microtomography, Phosphodiesterase 5 Inhibitors, medicine.disease, Biomechanical Phenomena, Rats, Nitric-Oxide, Disease Models, Animal, Primary bone, Vardenafil, 030220 oncology & carcinogenesis, Callus, Surgery, Original Article, femur, Mechanism, business, Femoral Fractures, Repair, medicine.drug

الوصف: Objectives: We aimed to investigate the radiological, biomechanical, histopathological, histomorphometric, and immunohistochemical effects of different doses of vardenafil on fracture healing. Materials and methods: Fifty-one rats were divided into three groups. Group V5 was given 5 mg/kg/day of vardenafil; Group V10 was given 10 mg/kg/day of vardenafil; and the control group was given the same volume of saline. Six rats from each group were sacrificed on Day 14 (early period) and the remaining rats were sacrificed on Day 42 (late period). Callus/femoral volume and bone mineral density were measured using micro- computed tomography. Five femurs from each group in the late period were examined by biomechanical tests. In addition to the histopathological and histomorphometric evaluations, immunohistochemical analyses were performed to examine the levels of inducible nitric oxide synthase (iNOS), transforming growth factor-3 (TGF-β3), and nuclear factor kappa B (NF-κB) proteins. Results: Both doses of vardenafil increased primary bone volume and maximal bone fracture strength in late period, compared to the control group (p^lt;0.05). Histological healing scores of vardenafil groups were significantly higher in early period (p Conclusion: During the first period of fracture healing process in which vasodilation is mostly required with increasing inflammation, vardenafil has ameliorating effects on the bone union and supports fracture healing.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254fa1b94c3e68b6bf6134038a9c68e6Test
http://europepmc.org/articles/PMC8343867Test

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Multicentric Giant Cell Tumor of Bone: Metachronous Presentation—a Case Report

المؤلفون: W. I. Faisham, Nur Asma Sapiai, W. S. Wan Fatihah, M. Z. Anani Aila

المصدر: Indian J Surg Oncol

الوصف: Giant cell tumors (GCT) of bone are a benign aggressive tumor with features of frequent local recurrence. It has the potential for metastasis and malignant transformation. GCT of bone represents about 4–9.5% of primary bone tumors. Metachronous GCT happen in less than 1% while metastatic spread in these lesions is very uncommon. Furthermore, reports of multicentric metachronous GCT are very rare in literature. We present a case of a 35-year-old male patient, who suffered from multicentric metachronous GCT, which involved the radius, humerus, femur, and pelvic with pulmonary metastasis. Local control by multiple resections of the tumor and chemotherapy for pulmonary metastases was able to control the disease with long-term survival and good functional outcome. These tumors had a typical radiological appearance and the diagnosis was confirmed on histopathology. Long follow-up needed in this case in view the illness occurs for long period.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0223e6f1214a9d3e32532ebeffd476a8Test
https://doi.org/10.1007/s13193-021-01331-7Test

9

Harmine targets inhibitor of DNA binding‐2 and activator protein‐1 to promote preosteoclast PDGF‐BB production

المؤلفون: Yong Zhou, You-You Li, Hui Xie, Hao Yin, Zheng-Zhao Liu, Jie Huang, Yi-Yi Wang, Chun-Yuan Chen, Xiong-Ke Hu, Meng-Lu Chen, Kun Xia, Zhen-Xing Wang, Zheng-Guang Wang, Jia Cao

المصدر: Journal of Cellular and Molecular Medicine

الوصف: Osteoporosis is one of the most common metabolic bone diseases affecting millions of people. We previously found that harmine prevents bone loss in ovariectomized mice via increasing preosteoclast platelet‐derived growth factor‐BB (PDGF‐BB) production and type H vessel formation. However, the molecular mechanisms by which harmine promotes preosteoclast PDGF‐BB generation are still unclear. In this study, we revealed that inhibitor of DNA binding‐2 (Id2) and activator protein‐1 (AP‐1) were important factors implicated in harmine‐enhanced preosteoclast PDGF‐BB production. Exposure of RANKL‐induced Primary bone marrow macrophages (BMMs), isolated from tibiae and femora of mice, to harmine increased the protein levels of Id2 and AP‐1. Knockdown of Id2 by Id2‐siRNA reduced the number of preosteoclasts as well as secretion of PDGF‐BB in RANKL‐stimulated BMMs administrated with harmine. Inhibition of c‐Fos or c‐Jun (components of AP‐1) both reversed the stimulatory effect of harmine on preosteoclast PDGF‐BB production. Dual‐luciferase reporter assay analyses determined that PDGF‐BB was the direct target of AP‐1 which was up‐regulated by harmine treatment. In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF‐BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870dac0fbdb71bc549a6b9e0d01f952Test
https://doi.org/10.1111/jcmm.16562Test

10

COMPARATIVE ANALYSIS OF QUANTITATIVE COMPUTED TOMOGRAPHY DATA AND HISTOLOGICAL FINDINGS IN PATIENTS WITH GIANT CELL BONE TUMOR TREATED WITH DENOSUMAB

المؤلفون: S. A. Tabakaev, I. G. Frolova, I. I. Anisenya, N. V. Vasilyev, A. V. Bogoutdinova, P. K. Sitnikov

المصدر: Sibirskij Onkologičeskij Žurnal, Vol 20, Iss 2, Pp 22-28 (2021)

الوصف: Background . Giant cell tumor of bone (GCTB) is a common benign lesion accounting for 4–9.5 % of all primary bone tumors. Although surgery is considered the method of choice in the treatment of GCT, however, denosumab, a genetically engineered drug with a novel mechanism of action, has been recently used to treat GCTB. Histological examination of a surgical specimen is undoubtedly the most objective method for assessing the effectiveness of the treatment. However, in some cases it is necessary to assess the effectiveness of conservative therapy at the stages of its implementation. The purpose of the study was to compare CT-densitometry findings with histological findings in GCTB patients treated with denosumab. Material and Methods. The study included 30 patients aged from 28 to 59 years with histologically verified GCTB, who received targeted therapy with denosumab followed by surgery. The changes in tumor structure during denosumab therapy and surgical specimens of the tumor were assessed. Results. The relationship between the CT-densitometry findings and histopathological findings of surgical specimens was revealed in GCTB patients treated with denosumab. Conclusion. CT-densitometry findings were shown can be used to predict pathological response of the tumor to denosumab treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fba444078943437128539e0977623eTest
https://doi.org/10.21294/1814-4861-2021-20-2-22-28Test

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