التفاصيل البيبلوغرافية
العنوان:
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
المؤلفون:
Lazar, AJ , McLellan, MD , Bailey, MH , Miller, CA , Appelbaum, EL , Cordes, MG , Fronick, CC , Fulton, LA , Fulton, RS , Mardis, ER , Schmidt, HK , Wong, W , Wilson, RK , Yellapantula, V , Radenbaugh, AJ , Hoadley, KA , Hayes, DN , Parker, JS , Wilkerson, MD , Auman, JT , Balu, S , Bodenheimer, T , Hoyle, AP , Jefferys, SR , Jones, CD , Lehmann, K-V , Meng, S , Mieczkowski, PA , Mose, LE , Perou, CM , Roach, J , Senbabaoglu, Y , Shi, Y , Simons, JV , Skelly, T , Soloway, MG , Tan, D , Veluvolu, U , Davis, IJ , Hepperla, AJ , Brohl, AS , Kasaian, K , Mungall, K , Sadeghi, S , Barthel, FP , Verhaak, R , Hu, X , Chibon, F , Cherniack, AD , Shih, J , Beroukhim, R , Meyerson, M , Cibulskis, C , Gabriel, SB , Saksena, G , Schumacher, SE , Gao, Q , Wyczalkowski, M , Bowlby, R , Robertson, AG , Ally, A , Balasundaram, M , Brooks, D , Carlsen, R , Chuah, E , Dhalla, N , Holt, RA , Jones, SJM , Lee, D , Li, I , Ma, Y , Marra, MA , Mayo, M , Moore, RA , Mungall, AJ , Schein, JE , Sipahimalani, P , Tam, A , Thiessen, N , Wong, T , Danilova, L , Cope, L , Baylin, SB , Bootwalla, MS , Lai, PH , Laird, PW , Maglinte, DT , Van Den Berg, DJ , Weisenberger, DJ , Wrangle, J , Drill, E , Shen, R , Iype, L , Reynolds, SM , Shmulevich, I , Yau, C , Armenia, J , Liu, EM , Benz, C , Pastore, A , Sanchez-Vega, F , Schultz, N , Akbani, R , Hegde, AM , Liu, W , Lu, Y , Mills, GB , Weinstein, JN , Roszik, J , Anur, P , Spellman, P , Abeshouse, A , Chen, H-W , Gao, J , Heins, Z , Kundra, R , Larsson, E , Ochoa, A , Sander, C , Socci, N , Zhang, H , Noble, MS , Heiman, DI , Kim, J , Chin, L , Getz, G , Cho, J , Defreitas, T , Frazer, S , Gehlenborg, N , Lawrence, MS , Lin, P , Meier, S , Voet, D , Byers, L , Diao, L , Gay, CM , Wang, J , Newton, Y , Cooper, LAD , Gutman, DA , Lee, S , Nalisnik, M , Bowen, J , Gastier-Foster, JM , Gerken, M , Helsel, C , Hobensack, S , Leraas, KM , Lichtenberg, TM , Ramirez, NC , Wise, L , Zmuda, E , Anderson, ML , Castro, P , Ittmann, M , Gordienko, E , Paklina, O , Setdikova, G , Raut, CP , Karlan, BY , Lester, J , Belyaev, D , Fulidou, V , Potapova, O , Voronina, O , Demetri, GD , Ramalingam, SS , Behera, M , Delman, K , Owonikoko, TK , Sica, GL , Boyd, J , Magliocco, A , Salner, A , Bennett, J , Iacocca, M , Swanson, P , Dottino, P , Kalir, T , Pereira, E , Akeredolu, T , Crain, D , Curley, E , Gardner, J , Mallery, D , Morris, S , Paulauskis, J , Penny, R , Shelton, C , Shelton, T , Thompson, E , Hoon, DB , Parfitt, J , Birrer, M , Karseladze, A , Mariamidze, A , Dao, F , Levine, DA , Olvera, N , Maki, RG , Bartlett, J , Eschbacher, J , Dubina, M , Mozgovoy, E , Fedosenko, K , Manikhas, G , Sekhon, H , Ramirez, N , Ingram, DR , Torres, KE , DiSaia, P , Godwin, AK , Godwin, EM , Kuo, H , Madan, R , Reilly, C , Adebamowo, C , Adebamowo, SN , Bocklage, T , Higgins, K , Martinez, C , Boice, L , Grilley-Olson, JE , Huang, M , Perou, AH , Thorne, LB , Rathmell, WK , Gutmann, DH , Singer, S , Chudamani, S , Liu, J , Lolla, L , Naresh, R , Pihl, T , Sun, Q , Wan, Y , Wu, Y , Felau, I , Zenklusen, JC , Demchok, JA , Ferguson, ML , Hutter, CM , Sofia, HJ , Tarnuzzer, R , Wang, Z , Yang, L , Zhang, JJ , Demicco, EG , Doyle, LA , Hornick, JL , Rubin, BP , de Rijn, MV , Baker, L , Riedel, RF , Ding, L , Ladanyi, M , Novak, JE , Van Tine, BA , Davis, LE , Grilley-Olsen, JE , Pollock, RE , Jones, KB , Martignetti, JA , Tong, P , Network, CGAR
المصدر:
Lazar, AJ; McLellan, MD; Bailey, MH; Miller, CA; Appelbaum, EL; Cordes, MG; et al.(2017). Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. CELL, 171(4), 950-+. doi: 10.1016/j.cell.2017.10.014. UCLA: Retrieved from: http://www.escholarship.org/uc/item/47j3z4n7Test
بيانات النشر:
The University of North Carolina at Chapel Hill University Libraries, 2017.
سنة النشر:
2017
مصطلحات موضوعية:
0301 basic medicine , Leiomyosarcoma , Adult , Epigenomics , DNA Copy Number Variations , Genomics , Biology , General Biochemistry, Genetics and Molecular Biology , Undifferentiated Pleomorphic Sarcoma , Article , 03 medical and health sciences , Young Adult , 0302 clinical medicine , medicine , Cluster Analysis , Humans , ATRX , Aged , Comparative genomics , Aged, 80 and over , Genome, Human , Sarcoma , Middle Aged , medicine.disease , Synovial sarcoma , 030104 developmental biology , 030220 oncology & carcinogenesis , Immunology , DNA methylation , Mutation , Cancer research , Genome-Wide Association Study
الوصف:
Summary Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes ( TP53 , ATRX , RB1 ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.
وصف الملف:
application/pdf
اللغة:
English
DOI:
10.17615/jcyr-9v75
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c86ec3399a3a9a3d27362677c3acb09Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....6c86ec3399a3a9a3d27362677c3acb09
قاعدة البيانات:
OpenAIRE
