The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota
| العنوان: | The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota |
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| المؤلفون: | Peng Wen, Dongmei Ouyang, Da Wang, Ya Song, Yu Wang, Jie Deng, Yuanming Sun, Yu-Zhong Chen, Yuxuan Liang, Hong Wang |
| المصدر: | International Journal of Molecular Sciences Volume 20 Issue 22 |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Constipation, medicine.medical_treatment, Substance P, Pharmacology, Gut flora, chemistry.chemical_compound, Mice, 0302 clinical medicine, RNA, Ribosomal, 16S, Defecation, Spectroscopy, Neurotransmitter Agents, biology, General Medicine, Biodiversity, Computer Science Applications, 030220 oncology & carcinogenesis, prebiotic, medicine.symptom, Acetylcholine, medicine.drug, neurotransmitter, Catalysis, Article, Nitric oxide, Inorganic Chemistry, 03 medical and health sciences, medicine, Animals, Physical and Theoretical Chemistry, 16S rRNA, Gastrointestinal Transit, Molecular Biology, Feces, Hexoses, gut microbiota, business.industry, Prebiotic, Organic Chemistry, constipation, biology.organism_classification, d-tagatose, Gastrointestinal Microbiome, 030104 developmental biology, Prebiotics, chemistry, Metagenomics, business |
| الوصف: | d-tagatose, a monosaccharide as well as a dietary supplement, has been reported as having a wide range of applicability in the food industry, however, the prebiotic activity, anticonstipation effects, and related mechanisms are still unclear. In this study, using the loperamide-induced constipation Kunming mice as the animal model, the effects of d-tagatose for the prevention of constipation were evaluated by gastrointestinal transit experiment and defecation experiment. Furthermore, the underlying mechanism was clarified by evaluating the change of the biochemical indicators and analyzing 16S rRNA amplicon of gut microbiota among the different mice groups. The results showed that the gastrointestinal transit rate, fecal number, and weight in six hours were significantly enhanced after the administration of d-tagatose. In addition, d-tagatose significantly increased the serum levels of acetylcholine (Ach) and substance P (SP), whereas the serum levels of nitric oxide (NO) were significantly decreased. Moreover, the 16S rRNA sequencing analysis revealed that the changes in the gut microbiota caused by constipation were restored by d-tagatose treatment. In conclusion, this study indicated that the administration of d-tagatose as a dietary supplement can effectively prevent and relieve constipation in Kunming mice, and it is a promising prebiotic candidate with constipation-relieving properties. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daace434f3b5b09006ed450834060e9Test http://europepmc.org/articles/PMC6887738Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8daace434f3b5b09006ed450834060e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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