Prognostic analysis of very early onset pancreatic cancer: a population-based analysis
| العنوان: | Prognostic analysis of very early onset pancreatic cancer: a population-based analysis |
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| المؤلفون: | Yanmei Wang, Dongjun Dai, Xinyang Hu, Xian Wang, Hongchuan Jin |
| المصدر: | PeerJ, Vol 8, p e8412 (2020) PeerJ |
| بيانات النشر: | PeerJ Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Multivariate statistics, Epidemiology, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Age, Pancreatic cancer, Internal medicine, Medicine, Very early onset pancreatic cancer, business.industry, General Neuroscience, lcsh:R, Cancer, General Medicine, Nomogram, medicine.disease, Prognosis, Regression, Competing risk model, 030220 oncology & carcinogenesis, Cohort, Adenocarcinoma, 030211 gastroenterology & hepatology, General Agricultural and Biological Sciences, business, Pancreatic adenocarcinoma |
| الوصف: | Background We aimed to use competing risk model to assess whether very early onset pancreatic cancer (VEOPC ) ( Methods We selected pancreatic adenocarcinoma (PDAC) patients as our cohort from the Surveillance, Epidemiology, and End Results (SEER) database. The impact of cancer specific death was estimated by competing risk analysis. Multivariate Fine-Gray regression for proportional hazards modeling of the subdistribution hazard (SH) model based nomogram was constructed, which was internally validated by discrimination and calibration with 1,000 bootstraps. Results Our cohort included 1,386 VEOPC patients and 53,940 older patients. We observed that in unresectablePDAC patients, VEOPC had better cancer specific survival (CSS) than each older group (45–59 years, 60–69 years, 70–79 years and >79 years). There was no significant prognostic difference between VEOPC and each older group in resectablePDAC. Our competing nomogram showed well discrimination and calibration by internal validation. Conclusion For unresectable PDAC patients, VEOPC had better CSS than older patients. Our competing risk nomogram might be an easy-to-use tool for the specific death prediction of VEOPC patients with PDAC. |
| اللغة: | English |
| تدمد: | 2167-8359 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bd802c80e9bc051f1655e4d7ea2c5aTest https://peerj.com/articles/8412Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....52bd802c80e9bc051f1655e4d7ea2c5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21678359 |
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