Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM)
| العنوان: | Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM) |
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| المؤلفون: | Lázaro Luciana, Eizaguirre Bárbara, Saladino María Laura, Hryb Javier, Tkachuk Verónica, Alves Pinheiro Amelia, Cohen Leila, Luetic Geraldine, Silva Emanuel, Agustín Pappolla, Deri Norma, Vrech Carlos, Barboza Andres, Carra Adriana, Balbuena María Eugenia, López Pablo, Carnero Contentti Edgar, RelevarEM investigators, Pita Cecilia, Garcea Orlando, Fernández Liguori Nora, Quarracino Cecilia, Alonso Ricardo, Divi Pablo, Menichini María Laura, Edgardo Cristiano, Zanga Gisela, Silva Berenice, Liliana Patrucco, Steinberg Judith, Jimena Miguez, Tavolini Dario, Rojas Juan Ignacio, Volman Gabriel |
| المصدر: | Neurological Sciences. 41:3329-3335 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pediatrics, Neurology, Expanded Disability Status Scale, business.industry, Multiple sclerosis, Dermatology, General Medicine, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Epidemiology, medicine, Ocrelizumab, 030212 general & internal medicine, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery, Neuroradiology, Cohort study, medicine.drug |
| الوصف: | Primary progressive multiple sclerosis (PPMS) is an infrequent clinical form of multiple sclerosis (MS). Scarce information is available about PPMS in Latin America. The aim of this work is to describe the clinical and demographic characteristics of PPMS patients in Argentina. RelevarEM is a longitudinal, strictly observational registry in Argentina. Clinical and epidemiological data from PPMS patients were described. There were 144 cases of PPMS. They represented 7% of MS patients. The mean age was 44.1 years. The female:male ratio was 1.08. The mean Expanded Disability Status Scale (EDSS) score was 5.5 and the mean disease evolution time was 10.6 years. Oligoclonal bands were found in 72.9%. At the time of diagnosis, magnetic resonance imaging showed spinal cord lesions in 82.6% and contrast-enhancing brain lesions in 18.1% of patients. Almost one third of patients were treated with a disease-modifying drug, and ocrelizumab was the most frequently used (55.8%). PPMS is an infrequent subtype of MS and its recognition is of the highest importance as it has its own evolution, treatment, and prognosis. The importance of our research resides in providing local data and contributing to a better understanding of PPMS and its treatment in Latin America. |
| تدمد: | 1590-3478 1590-1874 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5163b3e891ab540db8fdf270d9c850b8Test https://doi.org/10.1007/s10072-020-04680-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........5163b3e891ab540db8fdf270d9c850b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15903478 15901874 |
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