Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample
| العنوان: | Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample |
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| المؤلفون: | Bishwanath Pal, Ebony Liu, Rohan W Essex, Sotoodeh Abhary, Georgia Kaidonis, Jamie E Craig, Mark C Gillies, Alicia J. Jenkins, Ecosse L. Lamoureux, Jonathan M. Gleadle, John H Chang, Jolly Gilhotra, Kathryn P. Burdon, Nikolai Petrovsky, Mark Daniell, Alex W. Hewitt, Stewart Lake |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, endocrine system diseases, genetic structures, lcsh:Medicine, Type 2 diabetes, Severity of Illness Index, Haplogroup, 0302 clinical medicine, Polymorphism (computer science), 10. No inequality, lcsh:Science, Aged, 80 and over, Multidisciplinary, Diabetic retinopathy, Middle Aged, Mitochondria, Phenotype, Female, Adult, medicine.medical_specialty, Adolescent, Genotype, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Macular Edema, White People, Article, Young Adult, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, Aged, Glycated Hemoglobin, Diabetic Retinopathy, business.industry, lcsh:R, Australia, Case-control study, medicine.disease, United Kingdom, eye diseases, Diabetes Mellitus, Type 1, 030104 developmental biology, Diabetes Mellitus, Type 2, Case-Control Studies, lcsh:Q, business, 030217 neurology & neurosurgery, Human mitochondrial DNA haplogroup |
| الوصف: | Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d24796f4c0fbd3b73adca8cd063fcd3Test http://link.springer.com/article/10.1038/s41598-018-37388-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4d24796f4c0fbd3b73adca8cd063fcd3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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