المؤلفون: Ginger Tomberlin, Jeff Smith, James B. Stewart, Ugne Zekonyte, Claudia V. Pereira, Sandra R. Bacman, Carlos T. Moraes, Derek Jantz, Wendy Shoop

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nat Commun

مصطلحات موضوعية: 0301 basic medicine, Mitochondrial DNA, Mitochondrial Diseases, Science, Mutant, Genetic Vectors, Primary Cell Culture, General Physics and Astronomy, Mice, Transgenic, RNA, Transfer, Ala, Double-strand DNA breaks, Biology, medicine.disease_cause, DNA, Mitochondrial, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Gene therapy, medicine, Animals, Humans, Point Mutation, Gene, Genetics, Gene Editing, Transcription activator-like effector nuclease, Mutation, Multidisciplinary, Molecular medicine, Point mutation, General Chemistry, DNA Restriction Enzymes, Genetic Therapy, Dependovirus, Fibroblasts, Heteroplasmy, Mitochondria, Disease Models, Animal, 030104 developmental biology, Meganuclease, 030217 neurology & neurosurgery, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f9acba0c101ef2d066a602759ef34Test
https://pubmed.ncbi.nlm.nih.gov/34050192Test

المؤلفون: Diana Mnatsakanova, Tyler C. Huff, K. Mathews, Adriana P. Rebelo, Michael E. Shy, Eric A. Schon, Lisa Abreu, Amjad Farooq, Carlos T. Moraes, Claudia V. Pereira, Stephan Züchner, Hua Yang, Dimah Saade

المصدر: Brain. 141:662-672

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, biology, business.industry, ATP7A, Cardiomyopathy, Heterozygote advantage, medicine.disease, Compound heterozygosity, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, biology.protein, Cytochrome c oxidase, Missense mutation, Charcot-Marie-Tooth disease type 4, Neurology (clinical), Copper deficiency, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::44c66eb8a325a342af3577fd9425cef7Test
https://doi.org/10.1093/brain/awx369Test

المؤلفون: Francisca Diaz, Sandra R. Bacman, Tania Arguello, Susana Peralta, Claudia V. Pereira, Carlos T. Moraes

المصدر: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Medicine (General), medicine.medical_specialty, Genetic enhancement, Protein subunit, Reversion, NDUFS3, mitochondrial myopathies, QH426-470, medicine.disease_cause, Article, 03 medical and health sciences, Mice, R5-920, 0302 clinical medicine, Mitochondrial myopathy, Internal medicine, Conditional gene knockout, Genetics, medicine, Animals, Myopathy, Muscle, Skeletal, Adeno-associated virus, Musculoskeletal System, Mice, Knockout, Electron Transport Complex I, business.industry, complex I, adeno‐associated virus, Skeletal muscle, NADH Dehydrogenase, Genetic Therapy, medicine.disease, gene therapy, Mitochondria, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Molecular Medicine, Female, Genetics, Gene Therapy & Genetic Disease, medicine.symptom, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09372d14b1075861f9a5d80e6fbdedc1Test
https://pubmed.ncbi.nlm.nih.gov/31916679Test

المؤلفون: Antonio Moreno, Kendall B. Wallace, Francisco B. Pereira, Mariusz R. Wieckowski, Gonçalo C. Pereira, Nuno Lourenço, Paulo J. Oliveira, José A. Lumini, Claudia V. Pereira, José Magalhães, António Ascensão, Susana P. Pereira, James A. Bjork

المصدر: Pereira, G C, Pereira, S P, Pereira, F B, Lourenço, N, Lumini, J A, Pereira, C V, Bjork, J A, Magalhães, J, Ascensão, A, Wieckowski, M R, Moreno, A J, Wallace, K B & Oliveira, P J 2019, ' Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats ', Toxicological Sciences, vol. 169, no. 1, pp. 137-150 . https://doi.org/10.1093/toxsci/kfz026Test

مصطلحات موضوعية: 0301 basic medicine, Animal study, Male, Time Factors, Anthracycline, Heart Diseases, Cell Respiration, Principal component analysis, animal study, cardiotoxicity, doxorubicin, feature correlation analysis, mitochondrial permeability transition, principal component analysis, Mitochondrion, Pharmacology, Toxicology, Mitochondria, Heart, 03 medical and health sciences, 0302 clinical medicine, medicine, polycyclic compounds, Animals, Doxorubicin, Myocytes, Cardiac, Rats, Wistar, Mitochondrial permeability transition, Kidney, Cardiotoxicity, Antibiotics, Antineoplastic, business.industry, Hydrogen Peroxide, Feature correlation analysis, medicine.disease, Mitochondrial toxicity, 030104 developmental biology, medicine.anatomical_structure, Mitochondrial respiratory chain, Mitochondrial permeability transition pore, Electron Transport Chain Complex Proteins, Calcium, business, 030217 neurology & neurosurgery, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b914f9d2fbf032b2206e6d7eb5a5deeTest
https://pubmed.ncbi.nlm.nih.gov/30698778Test

المؤلفون: Sandra R. Bacman, Carlos T. Moraes, Claudia V. Pereira

المصدر: Mitochondrial Biology and Experimental Therapeutics ISBN: 9783319733432

مصطلحات موضوعية: 0301 basic medicine, Genetics, Transcription activator-like effector nuclease, Mitochondrial DNA, Mitochondrial disease, Point mutation, Haplotype, Mitochondrion, Biology, medicine.disease, Heteroplasmy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Genome editing, medicine, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::232136d24436de435c28ac8157b2ae4eTest
https://doi.org/10.1007/978-3-319-73344-9_24Test

المؤلفون: Roberta Brambilla, Mehran Taherian, Dmitry Ivanov, Han Gao, Galina Dvoriantchikova, Milena F. Pinto, Carlos T. Moraes, Stephanie McCarthy, Shreyans Patel, Kenji F. Tanaka, Claudia V. Pereira, Shaffiat Karmally, Pernille M. Madsen

المصدر: Madsen, P M, Pinto, M, Patel, S, McCarthy, S, Gao, H, Taherian, M, Karmally, S, Pereira, C V, Dvoriantchikova, G, Ivanov, D, Tanaka, K F, Moraes, C T & Brambilla, R 2017, ' Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury, and CNS inflammation ', Journal of Neuroscience, vol. 37, no. 42, pp. 10185-10199 . https://doi.org/10.1523/JNEUROSCI.1378-17.2017Test

مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Male, Axonal loss, Mitochondrion, DNA, Mitochondrial/genetics, Nerve Degeneration/genetics, Mice, 0302 clinical medicine, Inflammation/genetics, DNA Breaks, Double-Stranded, Research Articles, General Neuroscience, Experimental autoimmune encephalomyelitis, Mitochondria, Oligodendroglia/pathology, Oligodendroglia, medicine.anatomical_structure, Locomotion/physiology, Central Nervous System/pathology, Female, Demyelination, Locomotion, Mitochondrial DNA, Encephalomyelitis, Autoimmune, Experimental, Encephalomyelitis, Autoimmune, Experimental/genetics, Demyelinating Diseases/genetics, Mice, Transgenic, Biology, Neuroprotection, DNA, Mitochondrial, Multiple sclerosis, 03 medical and health sciences, medicine, Animals, Animal model, Oxidative phosphorylation, Remyelination, Inflammation, medicine.disease, Oligodendrocyte, Axons, Mice, Inbred C57BL, 030104 developmental biology, Axons/pathology, Nerve Degeneration, Neuroscience, 030217 neurology & neurosurgery, Demyelinating Diseases

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a5567ec98e9636c91559b0cac7181Test
https://pubmed.ncbi.nlm.nih.gov/28931570Test

المؤلفون: Alexandra Durr, Dagmar Timmann, Carlos T. Moraes, Lena Guillot-Noel, Adriana P. Rebelo, Giulia Coarelli, Claire Guissart, Christine Tranchant, Michel Koenig, Stephan Züchner, Claudia V. Pereira, Ludger Schöls, Matthis Synofzik, Giovanni Stevanin, Mathieu Anheim, Jack Howell, Andreas Traschütz, Vívian Pedigone Cintra, Ilse Eidhof, Bart P.C. van de Warrenburg, Annette Schenck

المساهمون: University of Miami Leonard M. Miller School of Medicine (UMMSM), Radboud university [Nijmegen], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Duisburg-Essen, University of Tübingen, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Deutsches Zentrum für Neurodegenerative Erkrankungen [Ulm] (DZNE)

المصدر: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, 144 (5), pp.1467-1481. ⟨10.1093/brain/awab071⟩
Brain, 144, 1467-1481
Brain 144(5), 1467-1481 (2021). doi:10.1093/brain/awab071
Brain, 144, 5, pp. 1467-1481

مصطلحات موضوعية: 0301 basic medicine, Male, Cerebellum, Peroxiredoxin III, MESH: Drosophila, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Medizin, Mitochondrion, medicine.disease_cause, 0302 clinical medicine, Loss of Function Mutation, MESH: Peroxiredoxin III, genetics [Oxidative Stress], MESH: Animals, genetics [Peroxiredoxin III], MESH: Middle Aged, MESH: Oxidative Stress, genetics [Cerebellar Ataxia], Neurodegeneration, ROS, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], 3. Good health, Pedigree, MESH: Cerebellar Ataxia, medicine.anatomical_structure, Cerebellar atrophy, Drosophila, Female, medicine.symptom, Adult, Ataxia, Cerebellar Ataxia, MESH: Pedigree, Biology, pathology [Cerebellar Ataxia], PRDX3, 03 medical and health sciences, metabolism [Cerebellar Ataxia], medicine, Animals, Humans, ddc:610, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], MESH: Humans, Cerebellar ataxia, ataxia, MESH: Adult, MESH: Loss of Function Mutation, medicine.disease, MESH: Male, Oxidative Stress, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Cancer research, Neurology (clinical), MESH: Female, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd12c82ab37550fb16aaa37fcee8ffTest