Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism
| العنوان: | Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism |
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| المؤلفون: | Furse, Samuel, Watkins, Adam J., Hojat, Nima, Smith, James, Williams, Huw E. L., Chiarugi, Davide, Koulman, Albert |
| المساهمون: | Koulman, Albert [0000-0001-9998-051X], Apollo - University of Cambridge Repository, Furse, Samuel [0000-0003-4267-2051], Watkins, Adam J. [0000-0002-0842-1251], Hojat, Nima [0000-0002-3255-1638], Smith, James [0000-0002-7465-6067], Williams, Huw E. L. [0000-0002-2623-6287], Chiarugi, Davide [0000-0003-2752-3189] |
| المصدر: | Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021) Communications Biology |
| بيانات النشر: | Nature Research, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Medicine (miscellaneous), Adipose tissue, chemistry.chemical_compound, Mice, Traffic Analysis, 0302 clinical medicine, 631/114/2398, Pregnancy, Triglyceride metabolism, Tissue Distribution, Biology (General), Dietary intake, article, Lipids, Prenatal Exposure Delayed Effects, Paternal Exposure, lipids (amino acids, peptides, and proteins), Female, General Agricultural and Biological Sciences, medicine.medical_specialty, Offspring, QH301-705.5, Phospholipid, 101/58, Biology, General Biochemistry, Genetics and Molecular Biology, Nutritional programming, 03 medical and health sciences, Computational platforms and environments, Internal medicine, medicine, Dietary Carbohydrates, Animals, 631/136/2435, Carbohydrate intake, 631/92/608, Lipidomics, Reprogramming, Lipid metabolism, Lipid Metabolism, Diet, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, chemistry, Animals, Newborn, 030217 neurology & neurosurgery |
| الوصف: | In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detailed lipid profiles were acquired from F1 neonate (3 weeks), F1 adult (16 weeks) and F2 neonate offspring in serum, liver, brain, heart and abdominal adipose tissues by MS and NMR. Using a purpose-built computational tool for analysing both phospholipid and fat metabolism as a network, we characterised the number, type and abundance of lipid variables in and between tissues (Lipid Traffic Analysis), finding a variety of reprogrammings associated with paternal diet. These results are important because they describe the long-term metabolic result of dietary intake by fathers. This analytical approach is important because it offers unparalleled insight into possible mechanisms for alterations in lipid metabolism throughout organisms. Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism. They use it to show that high paternal carbohydrate intake influences lipid metabolism in offspring two generations hence. |
| وصف الملف: | application/pdf; |
| تدمد: | 2399-3642 |
| DOI: | 10.17863/cam.63156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764ff7bfb187ee10819af4a149c38f5fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....764ff7bfb187ee10819af4a149c38f5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23993642 |
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| DOI: | 10.17863/cam.63156 |