Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
| العنوان: | Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery |
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| المؤلفون: | Zane Jaunmuktane, Sebastian Brandner, Annelies Quaegebeur, Miguel Viana-Baptista, Carolin Koriath, Ricardo Taipa, Simon Mead, Raf Sciot, Raquel Barbosa |
| المصدر: | Acta Neuropathologica |
| بيانات النشر: | Springer Berlin Heidelberg, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, Dura mater, Disease, Neurosurgical Procedures, 0302 clinical medicine, Traumatic brain injury, Fatal Outcome, Postoperative Complications, TBI, Medicine, CAA, Decontamination, Aβ, Aged, 80 and over, Transmission (medicine), Brain, Middle Aged, medicine.anatomical_structure, Female, Neurosurgery, Cerebral amyloid angiopathy, Adult, medicine.medical_specialty, Prion diseases, Context (language use), Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, mental disorders, Parenchyma, Transmission, Humans, Amyloid-β, Aged, Retrospective Studies, Original Paper, business.industry, Proteopathic seeding, medicine.disease, Head trauma, Transplantation, 030104 developmental biology, Intracerebral haemorrhage, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately three decades later, caused by severe CAA. None of these patients carried pathogenic mutations associated with early Aβ pathology development. In addition, we identified in the literature four patients with a history of neurosurgical intervention and subsequent development of CAA. These findings raise the possibility that Aβ pathology may be transmissible, as prion disease is, through neurosurgical procedures. Electronic supplementary material The online version of this article (10.1007/s00401-018-1822-2) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1432-0533 0001-6322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aa985b564307ae7a8572627ec2c8a6Test http://europepmc.org/articles/PMC5904220Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a2aa985b564307ae7a8572627ec2c8a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320533 00016322 |
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