Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
| العنوان: | Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients |
|---|---|
| المؤلفون: | Monica Moresco, Marco Filardi, Fabio Pizza, Vincenzo Donadio, Rocco Liguori, Luigi Ferini-Strambi, Alex Incensi, Stefano Vandi, Giuseppe Plazzi, Yuri L Sosero, Elena Antelmi, Sara Marelli, Raffaele Ferri |
| المساهمون: | Antelmi, E., Pizza, F., Donadio, V., Filardi, M., Sosero, Y. L., Incensi, A., Vandi, S., Moresco, M., Ferri, R., Marelli, S., Ferini-Strambi, L., Liguori, R., Plazzi, G., Antelmi, Elena, Pizza, Fabio, Donadio, Vincenzo, Filardi, Marco, Sosero, Yuri L, Incensi, Alex, Vandi, Stefano, Moresco, Monica, Ferri, Raffaele, Marelli, Sara, Ferini-Strambi, Luigi, Liguori, Rocco, Plazzi, Giuseppe |
| المصدر: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1872-1876 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Biopsy, Polysomnography, REM sleep behavior disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, narcolepsy, REM Sleep Behavior Disorder, Brief Communication, Gastroenterology, RBD, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, biomarkers, RC346-429, Pathological, Aged, Skin, medicine.diagnostic_test, business.industry, General Neuroscience, NARCOLEPSY, Middle Aged, medicine.disease, Pathophysiology, 030104 developmental biology, BIOMARKERS, REM SLEEP BEHAVIOR DISORDER, Skin biopsy, Sleep behavior, alpha-Synuclein, Female, Neurology. Diseases of the nervous system, Neurology (clinical), Corrigendum, business, Brief Communications, 030217 neurology & neurosurgery, Biomarkers, RC321-571, Narcolepsy |
| الوصف: | To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α‐synuclein deposits and whole‐night video‐polysomnography. Skin biopsy was positive for phosphorylated α‐synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video‐polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995c02c1f54ecd31ea3b74d1399633e1Test http://hdl.handle.net/11562/1008479Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....995c02c1f54ecd31ea3b74d1399633e1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |