التفاصيل البيبلوغرافية
العنوان:
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
المؤلفون:
Nicole Probst-Hensch , Idil Yet , Rui Xia , Jordana T. Bell , Luigi Ferrucci , Hannah R Elliott , Jaakko Kaprio , Melanie Waldenberger , Mika Kähönen , Seyma Katrinli , Paul Elliott , Kathryn L. Lunetta , Josine L. Min , Teemu Palviainen , Scott M. Ratliff , Dan Mason , Xiaochuan Wang , Donna K. Arnett , Paolo Vineis , Stefania Bandinelli , Linda Broer , Toshiko Tanaka , Daniel L. McCartney , Falk W. Lohoff , Pei-Lun Kuo , Roger L. Milne , Ake T. Lu , Stephen S. Rich , Silvia Polidoro , Karen N. Conneely , Andrew M. McIntosh , Jeesun Jung , David Van Den Berg , Yunzhang Wang , Marianne Nygaard , Ayoung Jeong , Konstantin Strauch , Eric Boerwinkle , Massimo Mangino , Melissa C. Southey , Caroline Hayward , Jack A. Taylor , Eco J. C. de Geus , Therese Tillin , Steve Horvath , Beate Ritz , Peter Durda , Ann Zenobia Moore , André G. Uitterlinden , Annette Peters , Silva Kasela , David J. Porteous , James G. Wilson , Wei Zhao , Terho Lehtimäki , Maria K. Sobczyk , Elina Sillanpää , Adolfo Correa , Rebecca C. Richmond , Zongli Xu , Myriam Fornage , Pamela R. Matias-Garcia , Medea Imboden , Ian J. Deary , Alicia K. Smith , Jie Yao , John Wright , Dorret I. Boomsma , Joanne M. Murabito , Mette Soerensen , Gail Davies , James S. Pankow , Pashupati P. Mishra , Alexandra M. Binder , Jennifer A. Smith , Sara Hägg , Gibran Hemani , Joyce B. J. van Meurs , Christian Gieger , Miina Ollikainen , Jenny van Dongen , Oliver Robinson , Marguerite R. Irvin , Wei Chen , Pei-Chien Tsai , Caroline L. Relton , Shengxu Li , Jacob K. Kresovich , Riccardo E. Marioni , Jonas Mengel-From , Deborah A. Lawlor , Xiuqing Guo , Matthijs D. van der Zee , Nancy L. Pedersen , Sarah E. Harris , Dianjianyi Sun , Rosie M. Walker , Pierre Antoine Dugué , Olli T. Raitakari , Laura M. Raffield , Kaare Christensen , Hemant K. Tiwari , Dale P. Sandler , Alexander P. Reiner , Amit Patki , Lili Milani , Jerome I. Rotter , Tom G. Richardson , Sharon L.R. Kardia
بيانات النشر:
Cold Spring Harbor Laboratory, 2020.
سنة النشر:
2020
مصطلحات موضوعية:
African american , Genetics , 0303 health sciences , dNaM , Genome-wide association study , Biology , Genome , 3. Good health , 03 medical and health sciences , 0302 clinical medicine , Ageing , DNA methylation , Parental longevity , Epigenetics , 030217 neurology & neurosurgery , 030304 developmental biology
الوصف:
Biological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic architecture underlying epigenetic ageing and its shared genetic contributions with lifestyle factors and longevity.
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2c1881dadc6c863e5931c8f31b752dTest https://doi.org/10.1101/2020.06.29.133702Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi...........bb2c1881dadc6c863e5931c8f31b752d
قاعدة البيانات:
OpenAIRE
