Stent and Dual Antiplatelet Therapy Duration Comparisons in the Setting of a Multicenter Randomized Controlled Trial: Can the Operator Experience Affect the Study Results?
| العنوان: | Stent and Dual Antiplatelet Therapy Duration Comparisons in the Setting of a Multicenter Randomized Controlled Trial: Can the Operator Experience Affect the Study Results? |
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| المؤلفون: | Alberto Cremonesi, Stephan Windecker, Federico Colombo, Marco Valgimigli, Fausto Castriota, Giuseppe Gargiulo, Gianfranco Percoco, Carlo Tumscitz, Gianluca Campo, Andrea Zuffi, Dik Heg, Fabrizio Ferrari |
| المساهمون: | Gargiulo, G., Heg, D., Ferrari, F., Percoco, G., Campo, G., Tumscitz, C., Colombo, F., Zuffi, A., Castriota, F., Cremonesi, A., Windecker, S., Valgimigli, M. |
| المصدر: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Gargiulo, Giuseppe; Heg, Dik; Ferrari, Fabrizio; Percoco, Gianfranco; Campo, Gianluca; Tumscitz, Carlo; Colombo, Federico; Zuffi, Andrea; Castriota, Fausto; Cremonesi, Alberto; Windecker, Stephan; Valgimigli, Marco (2017). Stent and Dual Antiplatelet Therapy Duration Comparisons in the Setting of a Multicenter Randomized Controlled Trial: Can the Operator Experience Affect the Study Results? Journal of the American Heart Association, 6(12), e007150. American Heart Association 10.1161/JAHA.117.007150 <http://dx.doi.org/10.1161/JAHA.117.007150Test> |
| بيانات النشر: | John Wiley and Sons Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, medicine.medical_treatment, Coronary Artery Disease, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Operator (computer programming), Randomized controlled trial, Coronary Restenosi, Retrospective Studie, law, Clinical endpoint, randomized trial, Stent, 030212 general & internal medicine, Myocardial infarction, 610 Medicine & health, Original Research, Clinical outcome, Interventional Cardiology, clinical outcomes, Drug Therapy, Combination, Female, Stents, Cardiology and Cardiovascular Medicine, 360 Social problems & social services, Human, medicine.medical_specialty, Time Factor, Affect (psychology), Drug Administration Schedule, Follow-Up Studie, NO, Coronary Restenosis, 03 medical and health sciences, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Pharmacology, business.industry, Platelet Aggregation Inhibitor, percutaneous coronary intervention, Percutaneous coronary intervention, medicine.disease, Clinical trial, operator, business, Platelet Aggregation Inhibitors, Follow-Up Studies |
| الوصف: | Background Operator experience influences outcomes after percutaneous coronary intervention, but this association in the controlled setting of a randomized, clinical trial is unclear. Methods and Results We investigated operator‐related outcomes (30‐day and 2‐year efficacy and safety end points) among patients undergoing percutaneous coronary intervention and randomized to different dual antiplatelet therapy durations and stent types. A total of 2003 patients were analyzed, and 7 operator groups were compared. The majority of preprocedural and postprocedural characteristics were imbalanced. The primary end point of the study, the composite of death, myocardial infarction, or cerebrovascular accidents, did not differ among operators at 30 days or 2 years. There were no significant differences also for all other individual and composite end points analyzed at 30 days and 2 years, except for 2‐year stent thrombosis ( P =0.048) and bleeding events ( P =0.022 for Bleeding Academic Research Consortium type 2, 3, or 5). Adjusted comparisons for the main end points showed slight differences among operators at 30 days, but not at 2 years. There was no interaction of operator with dual antiplatelet therapy duration ( P =0.112) or stent type ( P =0.300). Results remained entirely consistent when operators were stratified by their experience. Conclusions There was a weak signal of heterogeneity across study operators for the 30‐day, but not the 2‐year, main study outcomes. No clear effect of operator or operator experience was observed for the comparative efficacy and safety profile of the randomized stent types or dual antiplatelet therapy duration regimens. Clinical Trial Registration URL : http://www.clinicaltrials.govTest . Unique identifier: NCT 00611286. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2047-9980 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc69933da1cf0c04e8384254404da62Test http://europepmc.org/articles/PMC5779027Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0dc69933da1cf0c04e8384254404da62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20479980 |
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