Post-transplant manifestation of ankylosing spondylitis: a case report and review of literature
| العنوان: | Post-transplant manifestation of ankylosing spondylitis: a case report and review of literature |
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| المؤلفون: | Ilona Kurnatowska, Olga Brzezińska, Anna Zawiasa-Bryszewska, Joanna Makowska |
| المصدر: | BMC Nephrology BMC Nephrology, Vol 22, Iss 1, Pp 1-7 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nephrology, medicine.medical_specialty, medicine.medical_treatment, Chronic back pain, Case Report, lcsh:RC870-923, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Prednisone, Internal medicine, medicine, Back pain, Humans, Spondylitis, Ankylosing, 030212 general & internal medicine, Kidney transplantation, 030203 arthritis & rheumatology, Ankylosing spondylitis, business.industry, Correction, Immunosuppression, Middle Aged, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, Kidney Transplantation, Connective tissue disease, Immunosuppressive treatment, Surgery, Transplantation, Female, medicine.symptom, Ankylosing spondylitis case report, business, medicine.drug |
| الوصف: | Background Ankylosing spondylitis (AS) is an insidiously progressive and debilitating form of arthritis involving the axial skeleton, characterized by chronic back pain and progressive spinal stiffness, and lessening of pain and stiffness with exercise. Due to subsequent manifestation in different organs, AS causes reduction in life expectancy, so early diagnosis and treatment are of great importance. No AS cases have been reported in solid-organ transplant recipients yet. Case presentation A 58-year-old woman with end-stage renal disease due to chronic glomerulonephritis, after allogenic kidney transplantation 25 years earlier, with stable, good graft function, treated with chronic immunosuppressive therapy based on cyclosporine A, mycophenolate mofetil, and prednisone, with no previous history of a connective tissue disease presented fever up to 39 °C accompanied by pain localized in sacroiliac region radiating to the left lower limb. Detailed diagnostic procedures and x-rays of the lumbar spine and of the targeted sacroiliac joints revealed lesions characteristic of AS. Sulphasalazine was added to standard immunosuppression regimen with good clinical results. Conclusions We report an adult kidney transplant recipient with a new onset of AS. The risk of relapse or new onset of inflammatory disease in transplant recipients is extremely low due to immunosuppressive therapy following transplantation. However, when it occurs, the clinical presentation is commonly atypical, often leading to delayed diagnosis. |
| تدمد: | 1471-2369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515f501a623c479a333de01e07c3bd92Test https://doi.org/10.1186/s12882-021-02252-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....515f501a623c479a333de01e07c3bd92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712369 |
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