Time to Conversion to an Everolimus-Based Regimen: Renal Outcomes in Liver Transplant Recipients From the EVEROLIVER Registry
| العنوان: | Time to Conversion to an Everolimus-Based Regimen: Renal Outcomes in Liver Transplant Recipients From the EVEROLIVER Registry |
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| المؤلفون: | Christophe Duvoux, Daniel Eyraud, Rodolphe Sobesky, Guillaume Lasailly, Audrey Coilly, Sylvie Tresson, Olivier Boillot, Didier Samuel, Teresa Antonini, Valérie Cailliez, Yvon Calmus, Georges Philippe Pageaux, Martine Neau-Cransac, Faouzi Saliba, Ephrem Salamé, Eléonora Demartin, Sylvie Radenne, Jean Guguenheim, Jérôme Dumortier, Filomena Conti, Olivier Guillaud, Sébastien Dharancy |
| المساهمون: | Centre hépato-biliaire (CHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et traitement des maladies du foie, Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Hôpital Edouard Herriot [CHU - HCL], Centre Hospitalier Universitaire de Nice (CHU Nice), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), CHU Bordeaux [Bordeaux], Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| المصدر: | Liver Transplantation Liver Transplantation, Wiley, 2020, 26 (11), pp.1465-1476. ⟨10.1002/lt.25879⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Graft Rejection, MESH: Registries, medicine.medical_treatment, 030230 surgery, Liver transplantation, urologic and male genital diseases, 0302 clinical medicine, Registries, Graft Survival, Immunosuppression, 3. Good health, Liver, 030211 gastroenterology & hepatology, Female, MESH: Immunosuppressive Agents, France, Immunosuppressive Agents, medicine.drug, Glomerular Filtration Rate, medicine.medical_specialty, MESH: Liver Transplantation, MESH: Graft Survival, MESH: Transplant Recipients, Calcineurin Inhibitors, Urology, Renal function, MESH: Graft Rejection, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Everolimus, 03 medical and health sciences, medicine, Humans, Everolimus, Transplantation, MESH: Humans, Hepatology, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, Transplant Recipients, Liver Transplantation, Calcineurin, MESH: France, Regimen, MESH: Glomerular Filtration Rate, MESH: Calcineurin Inhibitors, Surgery, business, MESH: Female, Kidney disease, MESH: Liver |
| الوصف: | International audience; Longterm use of a calcineurin inhibitor (CNI)-based regimen is one of the major reasons for chronic renal failure in liver transplantation recipients (LTRs). The Everolimus Liver registry (EVEROLIVER) evaluated renal function in LTRs who were converted to everolimus (EVR). This observational registry included all LTRs receiving EVR across 9 centers from France. Data are being collected in an electronic database over 10 years (12 visits/patient) to evaluate efficacy, renal function (estimated glomerular filtration rate [eGFR]), and safety of EVR use in clinical practice, and the current analysis is reporting up to 60 months of findings. Until September 2017, 1045 patients received EVR after a mean time of 3.6 ± 5.1 years. CNI withdrawal was feasible in 57.7% of patients as of month 60. Mean eGFR improved in patients with baseline eGFR |
| تدمد: | 1527-6473 1527-6465 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd311cb690c91a9010f7f7518885564Test https://pubmed.ncbi.nlm.nih.gov/32890436Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6cd311cb690c91a9010f7f7518885564 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15276473 15276465 |
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