Ingestion of a Pre-bedtime Protein Containing Beverage Prevents Overnight Induced Negative Whole Body Protein Balance in Healthy Middle-Aged Men: A Randomized Trial
| العنوان: | Ingestion of a Pre-bedtime Protein Containing Beverage Prevents Overnight Induced Negative Whole Body Protein Balance in Healthy Middle-Aged Men: A Randomized Trial |
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| المؤلفون: | Leonidas G. Karagounis, Maurice Beaumont, Laurence Donato-Capel, Jean-Philippe Godin, Anne-France Kapp, Dimitrios Draganidis, Stéphane Pinaud, Jacques Vuichoud, Maya Shevlyakova, Koraljka Rade-Kukic, Denis Breuillé |
| المصدر: | Frontiers in Nutrition, Vol 6 (2019) Karagounis, Leonidas; Beaumont, Maurice; Donato-Capel, Laurence; Godin, Jean-Philippe; Kapp, Anne-France; Draganidis, Dimitrios; Pinaud, Stéphane; Vuichoud, Jacques; Shevlyakova, Maya; Rade-Kukic, Koraljka; Breuillé, Denis (2019). Ingestion of a Pre-bedtime Protein Containing Beverage Prevents Overnight Induced Negative Whole Body Protein Balance in Healthy Middle-Aged Men: A Randomized Trial. Frontiers in Nutrition, 6, p. 181. Frontiers Media 10.3389/fnut.2019.00181 <http://dx.doi.org/10.3389/fnut.2019.00181Test> Frontiers in Nutrition |
| بيانات النشر: | Frontiers Media SA, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Evening, muscle, Endocrinology, Diabetes and Metabolism, Protein metabolism, 610 Medicine & health, lcsh:TX341-641, 030209 endocrinology & metabolism, Bedtime, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 360 Social problems & social services, milk protein, Internal medicine, medicine, Ingestion, sleep, Nutrition, Original Research, 030109 nutrition & dietetics, Muscle biopsy, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, aging, protein balance, medicine.disease, Endocrinology, chemistry, Sarcopenia, Milk protein concentrate, Lean body mass, business, lcsh:Nutrition. Foods and food supply, Food Science |
| الوصف: | Age related muscle wasting leads to overall reductions of lean body mass, reduced muscle strength, and muscle function resulting in compromised quality of life. Utilizing novel nutritional strategies to attenuate such losses is of great importance in elderly individuals. We aimed to test if a complete dietary supplement containing 25 g of milk proteins and ingested in the evening before bed would improve protein metabolism in terms of whole body protein balance over a 10 h overnight period following ingestion of the test drink in healthy middle-aged male subjects. In addition we also assessed the rates of muscle protein synthesis during the second half of the night in order to see if previously reported extended amino acidemia during sleep results in increased rates of muscle protein synthesis. Seventeen healthy middle-aged male subjects (59.4 ± 3.2 year) consumed a dietary supplement drink at 21:00 containing either 25 g milk protein concentrate, 25 g maltodextrin, 7.75 g canola oil (treatment group), or an isocaloric protein void drink (placebo group). Muscle protein synthesis was assessed from a muscle biopsy following the continuous intravenous infusion of 13C-phenylalanine for 5 h (from 03:00 to 08:00). Whole body protein balance was greater in the treatment group (−0.13 ± 11.30 g prot/10 h) compared to placebo (−12.22 ± 6.91 g prot/10 h) (P ≤ 0.01). In contrast, no changes were observed on rates of muscle protein synthesis during the second half of the night. Ingestion of a dietary supplement containing 25 g of milk proteins significantly reduced the negative protein balance observed during the night. Therefore, pre-bedtime protein ingestion may attenuate overnight losses of lean tissue in healthy elderly men. Despite increases in aminoacidemia during the second part of the night, no changes were observed in the rates of muscle protein synthesis during this time. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02041143. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-861X |
| DOI: | 10.3389/fnut.2019.00181 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a4d5dde531935a29547c29a1e3edd7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....55a4d5dde531935a29547c29a1e3edd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296861X |
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| DOI: | 10.3389/fnut.2019.00181 |