المؤلفون: Sadanori Okada, Takehiro Sugiyama, Tomoaki Imamura, Tomoya Myojin, Hitoshi Ishii, Tsuneyuki Higashino, Tatsuya Noda, Shinichiro Kubo, Hiroki Nakajima, Yuichi Nishioka

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1797-1804 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Rate ratio, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Japan, Diabetes mellitus type 1, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, medicine, Humans, Poisson regression, Child, education, Aged, Retrospective Studies, Type 1 diabetes, education.field_of_study, business.industry, Incidence, Infant, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, medicine.disease, RC648-665, Confidence interval, Influenza, Diabetes Mellitus, Type 1, 030104 developmental biology, Child, Preschool, Cohort, symbols, Female, Original Article, business

الوصف: Aim This study aimed to determine whether there is an association between influenza and new‐onset type 1 diabetes. Materials and methods This population‐based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check‐ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new‐onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding. Results The data of 10,400 patients with new‐onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3‐fold (95% confidence interval: 1.15–1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times. Conclusions In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes increased after being diagnosed with influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2addc8fa0427d6b6ec3052b564d1117Test
https://doaj.org/article/6e005e4f525042c88b95614b668a0c6dTest

المؤلفون: Ya Hui Chang, Chung Yi Li, Santi Martini, Chin-Li Lu, Ming-Fong Chang

المصدر: Journal of Epidemiology
Journal of Epidemiology, Vol 31, Iss 9, Pp 503-510 (2021)

مصطلحات موضوعية: Adult, Male, Medicine (General), medicine.medical_specialty, standardized mortality ratio, Adolescent, type 1 diabetes, Epidemiology, Population, Taiwan, 030209 endocrinology & metabolism, Cohort Studies, Young Adult, 03 medical and health sciences, R5-920, 0302 clinical medicine, Cause of Death, Internal medicine, Diabetes mellitus, medicine, Humans, Clinical Epidemiology, 030212 general & internal medicine, Child, education, Cause of death, Type 1 diabetes, education.field_of_study, business.industry, Mortality rate, Infant, Newborn, Infant, General Medicine, Middle Aged, medicine.disease, mortality, Diabetes Mellitus, Type 1, Standardized mortality ratio, underlying cause of death, Child, Preschool, Cohort, Original Article, Female, business, Cohort study

الوصف: Background: To investigate all-cause and cause-specific mortality in Taiwanese patients with type 1 diabetes. Methods: A cohort of 17,203 patients with type 1 diabetes were identified from Taiwan’s National Health Insurance claims in the period of 1998–2014. Person-years were accumulated for each individual from date of type 1 diabetes registration to date of death or the last day of 2014. Age, sex, and calendar year standardized mortality ratios (SMRs) were calculated with reference to the general population. Results: In up to 17 years of follow-up, 4,916 patients died from 182,523 person-years. Diabetes (30.15%), cancer (20.48%), circulatory diseases (13.14%), and renal diseases (11.45%) were the leading underlying causes of death. Mortality rate (26.93 per 1,000 person-years) from type 1 diabetes in Taiwan was high, the cause of death with the highest mortality rate was diabetes (8.12 per 1,000 person-years), followed by cancer (5.52 per 1,000 person-years), and circulatory diseases (3.54 per 1,000 person-years). The all-cause SMR was significantly elevated at 4.16 (95% confidence interval, 4.04–4.28), with a greater all-cause SMR noted in females than in males (4.62 vs 3.79). The cause-specific SMR was highly elevated for diabetes (SMR, 16.45), followed by renal disease (SMR, 14.48), chronic hepatitis and liver cirrhosis (SMR, 4.91) and infection (SMR, 4.59). All-cause SMRs were also significantly increased for all ages, with the greatest figure noted for 15–24 years (SMR, 8.46). Conclusions: Type 1 diabetes in both genders and all ages was associated with significantly elevated SMRs for all-cause and mostly for diabetes per se and renal disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6e9ab22ff81a7a316d1593bcfc6bbdTest
https://doi.org/10.2188/jea.je20200026Test

المؤلفون: Elizabeth A. Cummings, Pam Talbot, Emily Haynes, Margaret Jean Dunbar, Marissa Ley

المصدر: Canadian Journal of Diabetes. 45:395-402

مصطلحات موضوعية: Adult, Male, Parents, Insulin pump, Gerontology, Financing, Government, Adolescent, Patients, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, media_common.quotation_subject, 030209 endocrinology & metabolism, Context (language use), Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Endocrinology, Quality of life (healthcare), Internal Medicine, medicine, Humans, 030212 general & internal medicine, Young adult, Child, Qualitative Research, media_common, Type 1 diabetes, business.industry, Insulin, General Medicine, medicine.disease, Government Programs, Diabetes Mellitus, Type 1, Nova Scotia, Quality of Life, Female, Worry, business, Program Evaluation, Qualitative research

الوصف: Background The Nova Scotia Insulin Pump Program (NSIPP) subsidizes the cost of insulin pump therapy for young patients (≤25 years) with type 1 diabetes. The first NSIPP evaluation focused on clinical outcomes rather than quality of life. Existing research on insulin pumps and quality of life is mostly survey based, with limited first-voice experiences. In this qualitative study, we examined patient and parent perspectives on how insulin pumps affect quality of life in the context of a government-funded program. Methods In this investigation, we used a phenomenological approach, guided by a conceptual model. In-depth semistructured telephone interviews (median, 37 minutes) were completed with NSIPP enrollees and/or their parents. Saturation was reached after 23 interviews. Verbatim transcripts were coded independently by 2 researchers. Coding discrepancies were discussed and resolved using concept mapping to clarify relationships between codes and to identify main themes. Results There were 2 main themes: 1) NSIPP financial support was necessary for those without private insurance and 2) control over life and diabetes with subthemes of social experiences and worry. Participants expressed this theme differently depending on their stage of life. For example, some children experienced shame and even hid their pump, whereas teens were more self-confident with the discreetness of pumps and young adults wore their pump with pride. Conclusions Insulin pump therapy, subsidized through the NSIPP, led to improved quality of life, which was experienced differently depending on stage of life.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740f7cfc04ec2e8c06737a3ec9b9a9b3Test
https://doi.org/10.1016/j.jcjd.2020.08.101Test

المؤلفون: Donna Cross, Tarini Chetty, Timothy W. Jones, Elizabeth A. Davis, Jennifer A. Nicholas, Leanne Fried, Lauren J. Breen, Tanyana Jackiewicz, Heather Roby

المصدر: Canadian Journal of Diabetes. 45:421-427

مصطلحات موضوعية: Adult, Male, Parents, Health Knowledge, Attitudes, Practice, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Social Stigma, Psychological intervention, 030209 endocrinology & metabolism, Developmental psychology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Young adult, Exercise, Competence (human resources), Qualitative Research, media_common, Type 1 diabetes, business.industry, General Medicine, Focus Groups, medicine.disease, Focus group, Diabetes Mellitus, Type 1, Content analysis, Female, business, Autonomy, Qualitative research

الوصف: Background Benefits of physical activity are well recognized for youth with type 1 diabetes mellitus (T1DM), but being active is challenging. In this study, we aimed to investigate the challenges experienced by adolescents, their parents and young adults with T1DM when they are physically active. Methods Six focus groups involving adolescents (13 to 18 years old, n=14) and young adults (19 to 25 years old, n=7) and 4 focus groups with parents (n=14) of the adolescents (13 to 18 years) were established. Data were analyzed using content analysis. Results Adolescents and young adults with T1DM identified challenges of unpredictability, knowledge, trust and stigma when they were physically active. Parent challenges were specifically unpredictability and trust. Conclusions Interventions are needed that provide adolescents and young adults with T1DM and parents of adolescents with T1DM more in-depth information about managing physical activity in a manner that enhances their perceived competence and builds autonomy. Interventions can also target peer and community support.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac29d98575b48616c61e7c1d9f1fcfaTest
https://doi.org/10.1016/j.jcjd.2020.09.010Test

المؤلفون: Ayman A. Al Hayek, Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert

المصدر: Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 15:747-751

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Saudi Arabia, Insulin delivery, 030209 endocrinology & metabolism, Glycemic Control, Hypoglycemic episodes, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Hypoglycemic Agents, Insulin, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Glycemic, Type 1 diabetes, business.industry, General Medicine, Prognosis, medicine.disease, Hypoglycemia, Diabetes Mellitus, Type 1, Postprandial, Patient Satisfaction, Female, business, Biomarkers, Follow-Up Studies

الوصف: Background and aims To determine the efficacy of i-Port Advance system on patients satisfaction and glycemic control among patients with type 1 diabetes (T1D). Methods This prospective study was performed among 73 patients with T1D (13–29 years) at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Demographic data were collected at baseline and clinical characteristics were collected at baseline and 12 weeks. Patients’ responses to Morisky Medication Adherence Scale (MMAS-8) and Insulin Delivery Satisfaction Survey (IDSS) were recorded at baseline and 12 weeks after initiating the i-Port Advance system. Results At 12 weeks, significant improvement was evident in the IDSS subscales, which comprises the IDSS effective (p = 0.048), burdensome (p = 0.032), and IDSS inconvenient (p = 0.001), with the total baseline IDSS score being 2.6 ± 0.42, and at 12 weeks being 3.7 ± 0.72 (p = 0.037). The MMAS total score at baseline was 4.6 ± 1.2, and at 12 weeks, it increased to 6.4 (p = 0.028). HbA1c level was 8.4% at baseline and decreased to 7.9% (p = 0.001) at 12 weeks. The total daily dose of insulin at baseline registered 0.9 ± 0.13, which declined to 0.8 ± 0.12 (p = 0.048) at 12 weeks. Fasting blood sugar value was 197 ± 23.4 at baseline, which dropped to 182 ± 24.5 at 12 weeks (p = 0.01); and the postprandial glucose at baseline was 195 ± 21.4 and declined to 177 ± 19.2 at 12 weeks (p = 0.01). The hypoglycemic episodes revealed a noteworthy reduction after the i-Port Advance system usage. Conclusion Use of i-Port Advance system was found to raise the patients’ satisfaction levels and lower both the hypoglycemic episodes as well as the HbA1c levels.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6747559d045720ca60ae9f0e324eaba1Test
https://doi.org/10.1016/j.dsx.2021.03.028Test

المؤلفون: Niels Jessen, Bjørn Richelsen, Steen B. Pedersen, Peter Breining, Jacob B. Hansen, Mads Kjolby

المصدر: Breining, P, Pedersen, S B, Kjolby, M, Hansen, J B, Jessen, N & Richelsen, B 2021, ' Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning ', European Journal of Endocrinology, vol. 184, no. 5, pp. 687-697 . https://doi.org/10.1530/EJE-20-0713Test

مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, Adipose Tissue, Brown/metabolism, Lipolysis, Endocrinology, Diabetes and Metabolism, Receptor expression, Parathyroid hormone, Adipose tissue, Parathyroid Hormone/pharmacology, 030209 endocrinology & metabolism, White adipose tissue, Lipolysis/drug effects, Adipose Tissue/drug effects, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Adipose Tissue, Brown, Receptor, Parathyroid Hormone, Type 1/metabolism, Adipocyte, Internal medicine, Brown adipose tissue, Adipocytes, medicine, Humans, Uncoupling Protein 1, Receptor, Parathyroid Hormone, Type 1, Aged, Chemistry, Thermogenesis/drug effects, Thermogenesis, Uncoupling Protein 1/metabolism, General Medicine, Middle Aged, Thermogenin, Cross-Sectional Studies, medicine.anatomical_structure, Adipose Tissue, Parathyroid Hormone, 030220 oncology & carcinogenesis, Female, hormones, hormone substitutes, and hormone antagonists, Adipocytes/drug effects

الوصف: Objective Activation of brown adipose tissue is a promising strategy to treat and prevent obesity and obesity-related disorders. Activation of uncoupling protein 1 (UCP1) leads to uncoupled respiration and dissipation of stored energy as heat. Induction of UCP1-rich adipocytes in white adipose tissue, a process known as ‘browning’, serves as an alternative strategy to increase whole body uncoupling capacity. Here, we aim to assess the association between parathyroid hormone (PTH) receptor expression and UCP1 expression in human adipose tissues and to study PTH effects on human white and brown adipocyte lipolysis and UCP1 expression. Design A descriptive study of human neck adipose tissue biopsies substantiated by an interventional study on human neck-derived adipose tissue cell models. Methods Thermogenic markers and PTH receptor gene expression are assessed in human neck adipose tissue biopsies and are related to individual health records. PTH-initiated lipolysis and thermogenic gene induction are assessed in cultured human white and brown adipocyte cell models. PTH receptor involvement is investigated by PTH receptor silencing. Results PTH receptor gene expression correlates with UCP1 gene expression in the deep-neck adipose tissue in humans. In cell models, PTH receptor stimulation increases lipolysis and stimulates gene transcription of multiple thermogenic markers. Silencing of the PTH receptor attenuates the effects of PTH indicating a direct PTH effect via this receptor. Conclusion PTH 1 receptor stimulation by PTH may play a role in human adipose tissue metabolism by affecting lipolysis and thermogenic capacity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9393d6212f2abdcb21a7db48ea58f29Test
https://doi.org/10.1530/eje-20-0713Test

المؤلفون: Tomasz Klupa, Tomasz Pałka, Maciej T. Malecki, Łukasz Tota, Małgorzata Morawska, Sandra Mrozinska, Beata Kieć-Wilk, Bartłomiej Matejko

المصدر: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1377-1385 (2021)

مصطلحات موضوعية: Blood Glucose, Male, Anaerobic Threshold, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Body fat percentage, Running, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, Type 1 diabetes, Insulin, 030212 general & internal medicine, Meals, Adiposity, Sex Characteristics, VO2 max, Articles, General Medicine, Clinical Science and Care, Original Article, Female, Adult, Insulin pump, medicine.medical_specialty, 030209 endocrinology & metabolism, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Lactic Acid, Cardiorespiratory fitness, Glycemic, Glycated Hemoglobin, Physical activity, business.industry, Blood Glucose Self-Monitoring, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, Physical Fitness, business, Stress, Psychological

الوصف: Aims/Introduction Regular physical activity for adults with type 1 diabetes mellitus improves cardiorespiratory fitness (CF) and quality of life. The aim of our study was to evaluate clinical and biochemical features that might be associated with CF in a homogenous group of adults with type 1 diabetes mellitus who are all treated with a personal insulin pump (continuous subcutaneous insulin infusion). Materials and Methods We assessed CF in 62 patients (74.2% of whom were men) who fulfilled the eligibility criteria. To determine maximal oxygen consumption, the march‐running test on the treadmill was carried out. Two hours before the test, the patients consumed a defined meal covered by a dose of rapid acting insulin analog that was reduced by 25% from their regular dose. Basal insulin infusion was reduced by 50% for an hour. Additionally, the Perceived Stress Scale‐10 questionnaire was used to measure the perception of stress. Results There was no episode of severe hypoglycemia during or after the test. In the final model, independent predictors of maximal oxygen consumption were sex, body fat percentage, lactate at 20 min after CF test and Perceived Stress Scale‐10 score. Of interest, neither short‐term (continuous glucose monitoring) nor long‐term (glycosylated hemoglobin) metabolic control parameters were predictors of CF. Conclusions In our selected homogenous group of patients with type 1 diabetes mellitus treated with personal insulin pumps, higher CF was associated with a lower percentage of body fat, male sex, higher lactate level after the CF test and the Perceived Stress Scale‐10 score. The proposed protocol in our cohort proved to be safe with regard to glycemic control.
Higher cardiorespiratory fitness (CF) was associated with a lower percentage of body fat, male sex, higher lactate level after the CF test and a Perceived Stress Scale‐10 score. Neither short‐term (continuous glucose monitoring) nor long‐term (glycosylated hemoglobin) metabolic control parameters were predictors of CF. We presented a simple protocol for carrying out CF tests which proved to be safe with regard to glycemic control in our cohort.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e872120d765f4f2c176dd850e4d51ca3Test
https://doi.org/10.1111/jdi.13490Test

المؤلفون: Marian C. Brennan, Nikos Ntoumanis, Janie Brown, Gavin D. Leslie

المصدر: Brennan, M C, Brown, J, Leslie, G D & Ntoumanis, N 2022, ' Acceptability of Self-Management Group Education to Reduce Fear of Hypoglycemia as a Barrier to Physical Activity in Adults With Type 1 Diabetes : A Mixed Methods Approach ', Canadian Journal of Diabetes, vol. 46, no. 1, pp. 16-25.e2 . https://doi.org/10.1016/j.jcjd.2021.04.008Test

مصطلحات موضوعية: diabetes mellitus type 1, fear of hypoglycemia, Adult, medicine.medical_specialty, self-management, Randomization, Adolescent, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Fidelity, 030209 endocrinology & metabolism, Hypoglycemia/prevention & control, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Randomized controlled trial, law, Intervention (counseling), Internal Medicine, adults, health education, Medicine, Humans, 030212 general & internal medicine, Child, Exercise, media_common, Self-management, exercise, business.industry, Self-Management, General Medicine, Fear, Focus group, Hypoglycemia, Diabetes Mellitus, Type 1, Helpfulness, Family medicine, Female, Diabetes Mellitus, Type 1/therapy, business, Social cognitive theory

الوصف: Objectives Mixed methods were used to evaluate a group self-management education intervention to address type 1 diabetes (T1D)-specific barriers to physical activity (PA). We evaluated the acceptability of study resources and procedures. Methods Consenting participants from a quantitative evaluation (n=70) were invited to participate in 1 of 5 focus groups. Interviews explored the acceptability of procedures across the randomized controlled trial schedule, acceptability of the intervention/control workshops and resources and the perceived effectiveness of the intervention/control on participant outcomes. The use and helpfulness of intervention take-home resources, Facebook data and fidelity coding were also examined to inform other aspects of intervention acceptability. Results Twenty-one focus group participants from control or intervention arms participated in 1 of the 5 focus groups. Participants were 46±10 years of age; about half were female and had been living with T1D for 23±16 years. Study procedures were widely accepted; however, randomization and some aspects of the questionnaire were of concern to a small number of participants. Group education was acceptable and preferred, but participants expressed ambivalence toward the private Facebook group. Control participants indicated that basic information on PA guidelines and hypoglycemia risk are not currently being provided in standard care. Fidelity assessment confirmed the intervention was delivered consistently and was facilitated using behaviours and communication skills based on Social Cognitive Theory. Conclusions Future definitive evaluation of this promising intervention should utilize a blinded randomized controlled trial study design. Alterations to the control workshop are required to better reflect standard care in Australia. Our qualitative findings suggest that group education can be an acceptable and preferred method of education in T1D management for PA.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a0bc2fa8394134e91bdcb1ae19bb78Test
https://findresearcher.sdu.dk:8443/ws/files/182064944/1_s2.0_S1499267121001295_main.pdfTest

المؤلفون: Darío Parra, Oscar Muñoz, Diana Henao, Marisol Vergara Pinilla, Martín Rondón, Alfonso Kerguelen, Ana María Gómez

المصدر: Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Diabetes & Metabolic Syndrome

مصطلحات موضوعية: Male, TIR, Time in range, Endocrinology, Diabetes and Metabolism, MDI, Multiple Doses of Insulin, Multiple dosing, Cohort Studies, SH, severe hypoglycemia, 0302 clinical medicine, Medicine, Prospective Studies, 030212 general & internal medicine, Zoom, Prospective cohort study, TBR, Time below the range, SAP, Sensor-augmented pump therapy, Sensor-augmented pump therapy (SAPT), General Medicine, Middle Aged, Telemedicine, T1D, Type 1 Diabetes, HCL, Hybrid Closed Loop, Type 1 diabetes, TAR, Time above the range, HU, hypoglycemia unawareness, CV%, coefficient of variation, Female, Cohort study, Adult, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), A1c, glycosylated hemoglobin, 030209 endocrinology & metabolism, Colombia, Article, Automated insulin delivery system (AID), Young Adult, 03 medical and health sciences, Insulin Infusion Systems, Physical medicine and rehabilitation, Patient Education as Topic, Internal Medicine, Humans, Hypoglycemic Agents, Virtual training, GMI, Glucose management indicator, CGM, continuous glucose monitoring, Aged, Glycemic, business.industry, Blood Glucose Self-Monitoring, COVID-19, IQR, Interquartile range, medicine.disease, Diabetes Mellitus, Type 1, PLGM, Predictive low-glucose management, Time in range, AID, Automated insulin delivery system, business, Hybrid closed loop (HCL), Follow-Up Studies

الوصف: Background and aims In Colombia, the government established mandatory isolation after the first case of COVID-19 was reported. As a diabetes care center specialized in technology, we developed a virtual training program for patients with type 1 diabetes (T1D) who were upgrading to hybrid closed loop (HCL) system. The aim of this study is to describe the efficacy and safety outcomes of the virtual training program. Method ology: A prospective observational cohort study was performed, including patients with diagnosis of T1D previously treated with multiple doses of insulin (MDI) or sensor augmented pump therapy (SAP) who were updating to HCL system, from March to July 2020. Virtual training and follow-up were done through the Zoom video conferencing application and Medtronic Carelink System version 3.1 software. CGM data were analyzed to compare the time in range (TIR), time below range (TBR) and glycemic variability, during the first two weeks corresponding to manual mode with the final two weeks of follow-up in automatic mode. Results 91 patients were included. Mean TIR achieved with manual mode was 77.3 ± 11.3, increasing to 81.6% ± 7.6 (p
Highlights • Hybrid closed-loop (HCL) systems allows type 1 diabetes (T1D) patients to improve Time in Range (TIR). • HCL training has been delivered in person. However, during COVID-19 pandemic we had to switch to a virtual modality. • Subjects with virtual training had an increase in TIR regardless of initial therapy after two weeks of automatic use. • This is the largest prospective non-sponsored study including adults treated with HCL trained through a virtual platform.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5881bb55526593b3ea173a4a4b845eTest
https://doi.org/10.1016/j.dsx.2020.12.041Test

المؤلفون: Rachel J. Burns, Kimia Fardfini

المصدر: Canadian Journal of Diabetes. 45:601-606

مصطلحات موضوعية: Adult, Male, Canada, medicine.medical_specialty, Sociodemographic Factors, Generalized anxiety disorder, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Health Behavior, education, 030209 endocrinology & metabolism, Type 2 diabetes, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Prevalence, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Psychiatry, Aged, media_common, business.industry, Flourishing, General Medicine, Middle Aged, Mental illness, medicine.disease, Health Surveys, Mental health, 3. Good health, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Mental Health, Diabetes Mellitus, Type 2, Community health, Happiness, Major depressive disorder, Female, business

الوصف: Objectives Current definitions of mental health are no longer limited to presence or absence of mental illness. Although dimensions of mental illness have been well studied among people with diabetes, little is known about positive mental health. Optimal positive mental health is referred to as “flourishing” and is characterized by happiness, psychological well-being and social well-being. Therefore, the purpose of this study was to examine the prevalence and correlates of flourishing mental health among Canadian adults diagnosed with diabetes. Methods Data came from participants >19 years of age in the Canadian Community Health Survey---Mental Health 2012, a national, cross-sectional survey. Positive mental health was measured with the Mental Health Continuum---Short Form, which categorizes individuals into flourishing, moderate and languishing mental health. Results Although the majority of participants with diabetes reported flourishing mental health (73.22%), flourishing mental health was more common among people without diabetes (76.56%). Among people with diabetes (n=2,024), those who were flourishing reported greater physical activity, better self-rated health, fewer comorbidities, less functional disability and were less likely to smoke compared with those who were not flourishing. Those who were flourishing were less likely to have a lifetime history of major depressive disorder or generalized anxiety disorder and were distinguished by some demographic characteristics. Conclusion Among people with diabetes, flourishing mental health was associated with distinct behavioural, health and sociodemographic correlates.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e70cd882802f2297cb7dbea623d865Test
https://doi.org/10.1016/j.jcjd.2020.12.001Test