Functional and morphological cardiovascular alterations associated with neurofibromatosis 1
| العنوان: | Functional and morphological cardiovascular alterations associated with neurofibromatosis 1 |
|---|---|
| المؤلفون: | Antonio Cutruzzolà, Concetta Irace, Agostino Gnasso, Jolanda Sabatino, Salvatore De Rosa, Ciro Indolfi, Rosa Gullace, Carmen Spaccarotella, Daniela Concolino, Marco Frazzetto |
| المساهمون: | Cutruzzola, A., Irace, C., Frazzetto, M., Sabatino, J., Gullace, R., De Rosa, S., Spaccarotella, C., Concolino, D., Indolfi, C., Gnasso, A. |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Blood viscosity, Hemodynamics, lcsh:Medicine, 030204 cardiovascular system & hematology, 0302 clinical medicine, Cardiovascular Disease, Brachial artery, lcsh:Science, Multidisciplinary, Heart Function Test, Middle Aged, Blood Viscosity, Peripheral, Carotid Arteries, Cardiovascular Diseases, Heart Function Tests, Cardiology, Female, Carotid artery structure, Disease Susceptibility, Human, Adult, Carotid Arterie, Cardiac function curve, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Neurofibromatosis 1, Adolescent, Ischemia, Article, Young Adult, 03 medical and health sciences, Internal medicine, medicine.artery, medicine, Humans, Hemodynamic, Neurofibromatosis, business.industry, lcsh:R, Biomarker, medicine.disease, nervous system diseases, 030104 developmental biology, Risk factors, Biomarkers, lcsh:Q, business |
| الوصف: | Subjects with Neurofibromatosis 1 (NF1) develop vascular complications. The protein product of the gene affected in NF1, neurofibromin, physiologically modulates endothelial function and preserves vascular and myocardial structure. Our study aimed to verify whether subjects with NF1 have early, preclinical abnormalities of carotid artery structure, brachial artery function, and cardiac function. We recruited 22 NF1 subjects without previous cardiovascular events and 22 healthy control subjects. All subjects underwent measurement of carotid artery intima-media thickness (IMT), evaluation of brachial artery endothelial function after ischemia and exercise, and cardiac function. Mean IMT was 543 ± 115 μ in NF1 subjects and 487 ± 70 μ in Controls (p p p p |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c1ae4921a393ac7cd1e4f1c10ec6efTest http://link.springer.com/article/10.1038/s41598-020-68908-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7c1ae4921a393ac7cd1e4f1c10ec6ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|