Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial
| العنوان: | Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial |
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| المؤلفون: | Roberto Reverberi, Elena Borotti, Maria Vittoria Riontino, Roberta Chicchi, M. R. Gamberini, Ruggero Buonocore, Daniela Lasagni, Giuseppina Angela Portararo, Monica Fortini, Eleonora Calori, Donatella Venturelli, Francesco Fagnoni, Maurizio Govoni, Alice Stievano, G. Ceccherelli, Rino Biguzzi |
| المصدر: | Transfusion |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Erythrocytes, Thalassemia, Immunology, Buffy coat, 030204 cardiovascular system & hematology, urologic and male genital diseases, Gastroenterology, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Immunology and Allergy, Medicine, Prospective Studies, Whole blood, Cross-Over Studies, Red Cell, Transfusion Medicine, business.industry, Transfusion Reaction, Plasmapheresis, Hematology, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Clinical trial, Treatment Outcome, Leukoreduction, Quartile, Female, Hemoglobin, Leukocyte Reduction Procedures, Erythrocyte Transfusion, business, RBC transfusion, 030215 immunology |
| الوصف: | Background The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences. Study Design and Methods The effects of two types of RCC (RCC‐A, RCC‐B) on transfusion regime were compared in a non‐blinded, prospective, randomized, two‐period, and crossover clinical trial. RCC‐A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC‐B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion‐dependent thalassemia (TDT). Results RCC‐A contained 63.9 (60.3–67.8) grams of hemoglobin per unit (median with 1st and 3rd quartile), RCC‐B 54.5 (51.0–58.2) g/unit. Fifty‐one patients completed the study. With RCC‐B, the average pre‐transfusion hemoglobin concentration was 9.3 ± 0.5 g/dl (mean ± SD), the average transfusion interval 14.2 (13.7–16.3) days, the number of RCC units transfused per year 39.3 (35.4–47.3), and the transfusion power index (a composite index) 258 ± 49. With RCC‐A, the average pre‐transfusion hemoglobin concentration was 9.6 ± 0.5 g/dl (+2.7%, effect size 0.792), the average transfusion interval 14.8 (14.0–18.5) days (+4.1%, effect size 0.800), the number of RCC units transfused per year 34.8 (32.1–42.5) (−11.4%, effect size −1.609), and the transfusion power index 272 ± 61 (+14.1%, effect size 0.997). All differences were statistically highly significant (p |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce97eb2cad00c7df448f5d2fa07a56fTest https://doi.org/10.1111/trf.16432Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dce97eb2cad00c7df448f5d2fa07a56f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
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