Evaluation of epicardial coronary resistance using computed tomography angiography
| العنوان: | Evaluation of epicardial coronary resistance using computed tomography angiography |
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| المؤلفون: | Emanuelle Barbato, Danny Schoors, Takuya Mizukami, Johan De Mey, Dries Belsack, Bram Roosens, J. F. Argacha, Bert Vandeloo, Kaoru Tanaka, Stijn Lochy, Daniele Andreini, Carlos Collet, Jeroen Sonck, Bernard De Bruyne, Bernard Cosyns, Hiroshi Suzuki |
| المساهمون: | Radiology, Medical Imaging, Clinical sciences, Cardiology, Cardio-vascular diseases, Intensive Care, Supporting clinical sciences, Body Composition and Morphology, Translational Imaging Research Alliance, Mizukami, T., Tanaka, K., Sonck, J., Vandeloo, B., Roosens, B., Lochy, S., Argacha, J. F., Schoors, D., Suzuki, H., Belsack, D., Andreini, D., Barbato, E., De Mey, J., De Bruyne, B., Cosyns, B., Collet, C., Graduate School, ACS - Heart failure & arrhythmias |
| المصدر: | Journal of cardiovascular computed tomography, 14(2), 177-184. Elsevier Inc. |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Coronary Vessels/diagnostic imaging, Fractional flow reserve, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Proof of Concept Study, 030218 nuclear medicine & medical imaging, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Pullback, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Coronary resistance, Computed tomography angiography, Cardiac catheterization, Aged, Medicine(all), medicine.diagnostic_test, business.industry, Coronary ct angiography, Middle Aged, medicine.disease, Coronary Vessels, medicine.anatomical_structure, fractional flow reserve, myocardial, Radiology Nuclear Medicine and imaging, Vascular resistance, Cardiology, Feasibility Studies, Female, Vascular Resistance, reproducibility of results, Cardiology and Cardiovascular Medicine, business, computed tomography angiography, Pericardium, Coronary Artery Disease/diagnostic imaging |
| الوصف: | Aims: Fractional flow reserve (FFR) pullback allows to assess the distribution of pressure loss along the coronary vessels. FFR derived from CT (FFR CT) provides a virtual pullback curve that may also aid in the assessment of the distribution of epicardial coronary resistance in the non-invasive setting. The present study aims to determine the accuracy of the virtual FFR CT pullback curve using a motorized invasive FFR pullback as reference in patients with stable coronary artery disease. Methods and results: FFR values were extracted from coronary vessels at approximately 1 mm to generate pullback curves. Invasive motorized FFR pullbacks were acquired using a dedicated device at a speed of 1 mm/s. A total of 3172 matched FFR CT and FFR values were obtained in 24 vessels. The correlation coefficient between FFR CT and FFR was 0.76 (95%CI 0.75 to 0.78; p < 0.001). The area under the pullback curve was similar between FFR CT and invasive FFR (79.0 ± 16.1 vs. 85.3 ± 16.4, p = 0.097). The mean difference in lesion gradient between FFR CT and FFR was −0.07 (LOA -0.26 to 0.13) whereas in non-obstructive segments was −0.01 (LOA -0.06 to 0.05). Conclusion: The evaluation of epicardial coronary resistance using coronary CT angiography with FFR CT was feasible. FFR CT virtual pullback appears to be accurate for the evaluation of pressure gradients. FFR CT has the potential to identify the pathophysiological pattern of coronary artery disease in the non-invasive setting. |
| اللغة: | English |
| تدمد: | 1934-5925 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3275833db9d566dd3d90d958e497a499Test https://hdl.handle.net/20.500.14017/dd055322-4fbf-4627-8858-819b2870a95eTest |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....3275833db9d566dd3d90d958e497a499 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19345925 |
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