IMSYC IMmunologic SYnovitis sCore: A New Score for Synovial Membrane Characterization In Inflammatory And Non-Inflammatory Arthritis
| العنوان: | IMSYC IMmunologic SYnovitis sCore: A New Score for Synovial Membrane Characterization In Inflammatory And Non-Inflammatory Arthritis |
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| المؤلفون: | S Touchais, T Garraud, Benoit Le Goff, Noura Biha, Vincent Crenn, Jérôme Amiaud, Guillaume Venet, Aurélie Najm, Veit Krenn, Frédéric Blanchard, Céline Charrier |
| المساهمون: | maurice, sandrine, Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238] (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de rhumatologie [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Département de Chirurgie Orthopédique [CHD de la Roche-sur-Yon], Centre Hospitalier Départemental site de la Roche-sur-Yon (CHD de la Roche-sur-Yon), Clinique chirurgicale orthopédique et traumatique [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Medical care centre [Trier, Germany] (MVZ), Zentrum für Histologie, Zytologie und Molekulare Diagnostik [Trier, Germany], This work was supported by Inserm, the Arthritis Foundation, Pfizer and the Région Pays de la Loire (Bioregate)., Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon |
| المصدر: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2018, Epub ahead of print. ⟨10.1016/j.jbspin.2018.04.004⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Inflammatory arthritis, Arthritis, Osteoarthritis, Gastroenterology, Severity of Illness Index, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Synovectomy, Synovitis, Internal medicine, medicine, Humans, 030212 general & internal medicine, Rheumatoid arthritis, 030203 arthritis & rheumatology, Inflammation, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Synovial Membrane, Biomarker, Middle Aged, medicine.disease, Immunohistochemistry, 3. Good health, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Biomarker (medicine), Female, Synovial membrane, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience; OBJECTIVES:Krenn synovitis Score has been developed by Krenn et al. in order to assess synovitis severity and is used in synovial research. Cell signature of synovial tissue can be studied using immunohistochemistry and is of interest as a biomarker for both prognosis and prediction of response to treatment. However, no synovitis score including immunohistochemistry exists yet. In order to answer this unmet need, we propose a new Immunologic SYnovitis sCore (IMSYC) adding 5 components to the Krenn score: CD68, CD3, CD20, CD31 and Ki67 immunostaining. In this study, we aimed to validate this new IMSYC by studying its diagnostic performances in a well-defined collection of synovial samples.METHODS:Synovial samples from patients were obtained during surgical procedures. CD68, CD3, CD20, CD31 and KI67 immunohistochemistry were performed.RESULTS:77 patients were included. 45 were females, mean age was 63.1 years. 40 had inflammatory arthritis, mainly rheumatoid arthritis (31/40). Non inflammatory arthritis group included 35 patients with mainly osteoarthritis. Mean Krenn score and IMSYC were significantly higher in the inflammatory group (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1297-319X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e78840ae79ae5233ec4a947f0496f9Test https://www.hal.inserm.fr/inserm-01792046Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2e78840ae79ae5233ec4a947f0496f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1297319X |
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