المؤلفون: Nauder Faraday, Brian D. Hobbs, Quan Sun, Michael Preuss, Ani Manichaikul, Eric Jorgenson, Ming-Huei Chen, Eric Boerwinkle, Florian Thibord, Arunoday Bhan, Alanna C. Morrison, Ramachandran S. Vasan, Nathan Pankratz, Charles Kooperberg, Deborah A. Nickerson, Joshua P. Lewis, Hélène Choquet, Jee-Young Moon, Jeffrey R. O'Connell, Marsha M. Wheeler, Albert V. Smith, Russell P. Tracy, Nathalie Chami, Ruth J. F. Loos, Alexander P. Reiner, Nicholas L. Smith, Gonçalo R. Abecasis, Laura M. Raffield, Amarise Little, Nancy L. Heard-Costa, Andrew D. Johnson, David C. Glahn, Rasika A. Mathias, Adam S. Butterworth, John Blangero, Joanne E. Curran, Timothy A. Thornton, Laura Almasy, Jerome I. Rotter, Nancy Min, Lisa R. Yanek, Donald M. Lloyd-Jones, Zhe Wang, Matthew P. Conomos, Myriam Fornage, Hua Tang, Lewis C. Becker, Lynette Ekunwe, Cecelia A. Laurie, Adolfo Correa, Jai G. Broome, Terri H. Beaty, Jennifer A. Brody, Caitlin P. McHugh, Yao Hu, Braxton D. Mitchell, Lifang Hou, Yun Li, Kathleen A. Ryan, Paul L. Auer, Stephen S. Rich, Kari E. North, Thomas W. Blackwell, Bruce M. Psaty, Deepti Jain, Paul S Vries, Praveen Surendran

المساهمون: Butterworth, Adam [0000-0002-6915-9015], Apollo - University of Cambridge Repository

المصدر: Human molecular genetics, vol 31, iss 3
Hum Mol Genet

مصطلحات موضوعية: Blood Platelets, Platelet disorder, Population, Genome-wide association study, Biology, Quantitative trait locus, Polymorphism, Single Nucleotide, Medical and Health Sciences, Genome, 03 medical and health sciences, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, 0302 clinical medicine, Clinical Research, and Blood Institute (U.S.), Genetics, Humans, 2.1 Biological and endogenous factors, Polymorphism, Precision Medicine, Aetiology, Mean platelet volume, education, Hemostatic function, Lung, Molecular Biology, Genetics (clinical), 030304 developmental biology, Blood Platelet Disorders, Genetics & Heredity, 0303 health sciences, education.field_of_study, Human Genome, Single Nucleotide, National Heart, Hematology, General Medicine, Biological Sciences, United States, 3. Good health, Phenotype, Good Health and Well Being, 030220 oncology & carcinogenesis, General Article, National Heart, Lung, and Blood Institute (U.S.), Genome-Wide Association Study, Biotechnology

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc9557e325812482460ef4586ad1a77Test
https://doi.org/10.1093/hmg/ddab252Test

المؤلفون: Adolfo Correa, Jai G. Broome, Chunyan Ren, Kari E. North, Nancy L. Heard-Costa, Yao Yao, Brian D. Hobbs, Mary Cushman, Leslie A. Lange, Daniel E. Bauer, Xiuwen Zheng, Braxton D. Mitchell, Yun Li, Quan Sun, Sébastian Méric de Bellefon, Terri H. Beaty, Paul S. de Vries, Ruth J. F. Loos, Adrienne M. Stilp, Albert V. Smith, Paul L. Auer, Deepti Jain, Lifang Hou, Robert C. Kaplan, Jee-Young Moon, Michael Preuss, Stephen S. Rich, Guillaume Lettre, Nicole Soranzo, Eric Boerwinkle, Kousik Kundu, Laura Almasy, Marsha M. Wheeler, Thomas W. Blackwell, Nancy Min, Nicholas L. Smith, Bruce M. Psaty, Lisa R. Yanek, Joanne E. Curran, Stacey Gabriel, Kathleen A. Ryan, Alanna C. Morrison, Lynette Ekunwe, Caitlin P. McHugh, Laura M. Raffield, Adam S. Butterworth, Deborah A. Nickerson, Ravindranath Duggirala, Gonçalo R. Abecasis, John Lane, Hélène Choquet, Andrew D. Johnson, Nauder Faraday, Russell T. Walton, Praveen Surendran, Jennifer A. Brody, Yao Hu, Alexander P. Reiner, Jerome I. Rotter, Donald M. Lloyd-Jones, Cathy C. Laurie, Zhe Wang, Hua Tang, Charles Kooperberg, Eric Jorgenson, Jeffrey R. O'Connell, Shuquan Rao, Nathalie Chami, Rasika A. Mathias, Matthew P. Conomos, Myriam Fornage, Ramachandran S. Vasan, Nathan Pankratz, Joshua P. Lewis, Lewis C. Becker, Benjamin P. Kleinstiver, Cecelia A. Laurie, Ming-Huei Chen, John Blangero

المصدر: Am J Hum Genet

مصطلحات موضوعية: Adult, Male, Quality Control, 0301 basic medicine, Erythrocytes, Population, Datasets as Topic, Genome-wide association study, Biology, Quantitative trait locus, Article, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, Indel, education, Gene, Genetics (clinical), Aged, Genetic association, Gene Editing, Whole genome sequencing, education.field_of_study, Genetic Variation, Reproducibility of Results, Correction, Middle Aged, United States, Genetic architecture, HEK293 Cells, Phenotype, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, National Heart, Lung, and Blood Institute (U.S.), Chromosomes, Human, Pair 16, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b87edb710dac1b94b0361a1b7107d06Test
https://doi.org/10.1016/j.ajhg.2021.04.003Test

المؤلفون: Andrew D Beswick, Tõnu Esko, Niki Dimou, Xue Zhong, Jette Bork-Jensen, Petra Schubert, Masato Akiyama, Girish N. Nadkarni, Ruth J. F. Loos, Huijun Qian, Michele K. Evans, Stephen S. Rich, Nicole Soranzo, Henry Völzke, Yongmei Liu, Nicholas A. Watkins, Markus M. Lerch, Richard C. Trembath, Adam S. Butterworth, Erwin P. Bottinger, Jennifer E. Huffman, Bruce M. Psaty, Jingzhong Ding, Michael Preuss, Yoav Ben-Shlomo, Bhavi Trivedi, Yoichiro Kamatani, David A. van Heel, Kjell Nikus, Torben Hansen, Adolfo Correa, Mohsen Ghanbari, Paul L. Auer, Véronique Laplante, Ken Sin Lo, Hua Tang, Peter W.F. Wilson, Paul Elliott, David J. Roberts, Hilary C. Martin, Jean-Claude Tardif, Praveen Surendran, Regina Manansala, Terho Lehtimäki, Emanuele Di Angelantonio, Fotis Koskeridis, Alexander P. Reiner, Mélissa Beaudoin, Vijay G. Sankaran, Benjamin Rodriguez, William J. Astle, Parsa Akbari, Frank J. A. van Rooij, Yun Li, Andreas Greinacher, Abdou Mousas, Andrew D. Johnson, Yukinori Okada, Michael H. Guo, Leo-Pekka Lyytikäinen, Traci M. Bartz, Minhui Chen, Alan B. Zonderman, Niels Grarup, Oluf Pedersen, Kumaraswamynaidu Chitrala, Jeffrey Haessler, Ming-Huei Chen, Cassandra N. Spracklen, Karen L. Mohlke, Guillaume Lettre, Erik L. Bao, Bingshan Li, James S. Floyd, Wei Huang, Ani Manichaikul, John Danesh, Uwe Völker, Allan Linneberg, Evangelos Evangelou, Joanna M. M. Howson, Olli T. Raitakari, Tim Kacprowski, Jean-François Gauchat, Hélène Choquet, Arden Moscati, Saori Sakaue, Mika Kähönen, Linda Broer, Caleb A. Lareau, Qin Qin Huang, Matthias Nauck, Yoshinori Murakami, Charleston W. K. Chiang, VA Million Veteran Program, Nina Mononen, Tao Jiang, Laura M. Raffield, Jerome I. Rotter, Leslie A. Lange, Jonathan D. Rosen, Eric Jorgenson, Savita Karthikeyan, Karen A. Hunt, Nathan Pankratz, Kelly Cho, Masahiro Kanai, Willem H. Ouwehand, Jennifer A. Brody, Koichi Matsuda, Dragana Vuckovic

المساهمون: Epidemiology, Internal Medicine

المصدر: Cell
Lettre, G & Auer, P L 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-1213.e14 . https://doi.org/10.1016/j.cell.2020.06.045Test
Cell, 182(5), 1198-1213.e14. Cell Press
Chen, M-H, Raffield, L M, Mousas, A, Sakaue, S, Huffman, J E, Moscati, A, Trivedi, B, Jiang, T, Akbari, P, Vuckovic, D, Bao, E L, Zhong, X, Manansala, R, Laplante, V, Chen, M, Lo, K S, Qian, H, Lareau, C A, Beaudoin, M, Hunt, K A, Akiyama, M, Bartz, T M, Ben-Shlomo, Y, Beswick, A, Bork-Jensen, J, Bottinger, E P, Brody, J A, van Rooij, F J A, Chitrala, K, Cho, K, Choquet, H, Correa, A, Danesh, J, Di Angelantonio, E, Dimou, N, Ding, J, Elliott, P, Esko, T, Evans, M K, Floyd, J S, Broer, L, Grarup, N, Guo, M H, Greinacher, A, Haessler, J, Hansen, T, Howson, J M M, Linneberg, A, Pedersen, O, Loos, R J F & VA Million Veteran Program 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-+ . https://doi.org/10.1016/j.cell.2020.06.045Test

مصطلحات موضوعية: LOCI, Mutation, Missense, Ethnic group, POLYGENIC RISK SCORES, HUMAN HEMATOPOIESIS, Biology, BIOBANK, phenome-wide association study, Polymorphism, Single Nucleotide, DISEASE, White People, General Biochemistry, Genetics and Molecular Biology, Article, Blood cell, 03 medical and health sciences, SINGLE-CELL, selective sweeps, 0302 clinical medicine, Asian People, parasitic diseases, Genetics, medicine, Humans, GENOME-WIDE ASSOCIATION, 030304 developmental biology, AFRICAN-AMERICANS, 0303 health sciences, interleukin-7, Interleukin-7, genetic architecture, Genetic architecture, TRAIT, HEK293 Cells, Phenotype, medicine.anatomical_structure, fine-mapping, polygenic trait score, lipids (amino acids, peptides, and proteins), FREQUENCY CODING VARIANTS, 030217 neurology & neurosurgery, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1811f60972354d4d9bffd608966f4eaTest
https://pure.eur.nl/en/publications/b0512e42-bb15-4b65-9524-08ef2dd4cd7dTest

المؤلفون: Ci Song, Christopher J. O'Donnell, Weihong Tang, Karl C. Desch, Xiuqing Guo, Aaron R. Folsom, Rasika A. Mathias, David-Alexandre Trégouët, Eleanor M. Simonsick, Jerome I. Rotter, Ming-Huei Chen, Germán D. Carrasquilla, Winfried März, Nicholas L. Smith, Pierre-Emmanuel Morange, Russel Tracy, Maria Sabater-Lleal, Diane M. Becker, Jie Yao, Lisa R. Yanek, Oluf Pedersen, Tuomas O. Kilpeläinen, Hampton L. Leonard, Jennifer A. Brody, Gerard Temprano-Sagrera, Allan Linneberg, Florian Thibord, Torben Hansen, Marcus E. Kleber, Mary Cushman, Jack Pattee, Lewis C. Becker, Hugh Watkins, Niels Grarup, Marta Guindo-Martínez, Nathan Pankratz, Anders Hamsten, Ayse Bilge Ozel, Angela Silveira, Mike A. Nalls, Benjamin Rodriguez, Kent D. Taylor, Laura M. Raffield, Andrew D. Johnson, Paul S. de Vries, Barbara McKnight, Graciela E. Delgado, Alanna C. Morrison, Beata Gyorgy, Bruce M. Psaty

المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Wiley, 2021, ⟨10.1111/jth.15345⟩
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
J Thromb Haemost
Journal of Thrombosis and Haemostasis, 2021, ⟨10.1111/jth.15345⟩
Journal of thrombosis and haemostasis : JTH, vol 19, iss 8

مصطلحات موضوعية: medicine.medical_treatment, Clinical Sciences, Locus (genetics), Cardiorespiratory Medicine and Haematology, 030204 cardiovascular system & hematology, Biology, Fibrinogen, Tissue plasminogen activator, Article, Fibrin Fibrinogen Degradation Products, Computational biology, 03 medical and health sciences, computational biology, 0302 clinical medicine, Clinical Research, Plasminogen Activator Inhibitor 1, Fibrinolysis, Genetics, medicine, Humans, Exome, Allele frequency, Gene, Genetic association study, Prevention, Human Genome, Hematology, FGL1, Cardiovascular System & Hematology, Tissue Plasminogen Activator, genetic association study, fibrinolysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, fibrinogen, exome, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1922d03d8fbb3c0db519c3c36aad91f8Test
https://hal.archives-ouvertes.fr/hal-03274625Test

المؤلفون: Tanika N. Kelly, May E Montasser, Alyna T. Khan, Laura M. Raffield, Carla Wilson, Elizabeth C. Oelsner, Kerri L. Wiggins, Ming-Huei Chen, Gina M. Peloso, Adolfo Correa, Andrew D. Johnson, Donna K. Arnett, Xiuqing Guo, Jai G. Broome, Daniel E. Weeks, Rebecca D. Jackson, Lucia Juarez, Stephen T. McGarvey, Pradeep Natarajan, Braxton D. Mitchell, Kent D. Taylor, Bruce M. Psaty, Santhi K Ganesh, Cathy C. Laurie, Nicola L. Hawley, Leslie S. Emery, Adrienne M. Stilp, Alanna C. Morrison, Jennifer A Smith, Charles Kooperberg, Catherine M. D’Augustine, Jan Graffelman, Paul S. de Vries, Chancellor Hohensee, Sharon L R Kardia, Patricia A Peyser, Wan-Ling Hsu, Erin J Buth, Kathleen C. Barnes, Susan R. Heckbert, Ramachandran S. Vasan, Nathan Pankratz, Karen M. Mutalik, Quenna Wong, Brian E. Cade, Jingmin Liu, Joshua C. Bis, Cecelia A. Laurie, Kari E. North, Fei Fei Wang, Mariza de Andrade, Nancy L. Heard-Costa, William Craig Johnson, L. Adrienne Cupples, Scott T. Weiss, Seyed Mehdi Nouraie, Patrick T. Ellinor, Jerome I. Rotter, Weiniu Gan, Shannon Kelly, Stephen S. Rich, Cashell E. Jaquish, Dongquan Chen, Nora Franceschini, Lisa R. Yanek, Jiwon Lee, Alexander P. Reiner, Megan L. Grove, Stella Aslibekyan, Myriam Fornage, Lawrence F Bielak, Rasika A. Mathias

المساهمون: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis

المصدر: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
American Journal of Epidemiology
American journal of epidemiology, vol 190, iss 10

مصطلحات موضوعية: 0301 basic medicine, Program evaluation, Computer science, Epidemiology, common data elements, hematologic disease, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Medical and Health Sciences, Mathematical Sciences, 0302 clinical medicine, Documentation, cardiovascular disease, and Blood Institute (U.S.), 030212 general & internal medicine, Phenomics, Precision Medicine, Lung, lung diseases, Sleep-wake disorders, phenotypes, 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS], Common data elements, Cardiovascular disease, Phenotype, Phenotypes, Biomatemàtica, Information Dissemination, Harmonization, 62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Hematologic disease, 03 medical and health sciences, Data Aggregation, Clinical Research, Controlled vocabulary, Genetics, Humans, AcademicSubjects/MED00860, sleep-wake disorders, Sampling (Statistics), Genetic Association Studies, Lung diseases, Biomathematics, Data collection, Study Design, Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC], Information dissemination, Human Genome, National Heart, Precision medicine, Data science, United States, 030104 developmental biology, Good Health and Well Being, National Heart, Lung, and Blood Institute (U.S.), Mostreig (Estadística), Program Evaluation

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0380088474cfe1cc5218a3fad8da984aTest
http://hdl.handle.net/2117/359840Test

المؤلفون: Ming-Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Arden Moscati, Xue Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A. Lareau, Mélissa Beaudoin, Masato Akiyama, Traci M. Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P. Bottinger, Jennifer A. Brody, Frank J.A. van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K. Evans, James S. Floyd, Linda Broer, Niels Grarup, Michael H. Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna M. M. Howson, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A. Lange, Terho Lehtimäki, Markus M. Lerch, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Koichi Matsuda, Karen L. Mohlke, Nina Mononen, Yoshinori Murakami, Girish N. Nadkarni, Matthias Nauck, Kjell Nikus, Willem H. Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Olli T. Raitakari, David J. Roberts, Stephen S. Rich, Benjamin A.T. Rodriguez, Jonathan D. Rosen, Jerome I. Rotter, Petra Schubert, Cassandra N. Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A. Watkins, Alan B. Zonderman, VA Million Veteran Program, Peter W.F. Wilson, Yun Li, Adam S. Butterworth, Jean-François Gauchat, Charleston W.K. Chiang, Bingshan Li, Ruth J.F. Loos, William J. Astle, Evangelos Evangelou, Vijay G. Sankaran, Yukinori Okada, Nicole Soranzo, Andrew D. Johnson, Alexander P. Reiner, Paul L. Auer, Guillaume Lettre

مصطلحات موضوعية: Blood cell, Genetics, 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, Ethnic group, Genome-wide association study, Biology, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f628af808f38d9ca9ae061174848ae3Test
https://doi.org/10.1101/2020.01.17.910497Test

المؤلفون: Nicholas A. Watkins, Julian C. Knight, William J. Astle, Stephan B. Felix, Petra Schubert, Andreas Greinacher, Laura M. Raffield, Guillaume Lettre, Leslie A. Lange, Erwin P. Bottinger, Jonathan D. Rosen, Frank J. A. van Rooij, Tim Kacprowski, Hua Tang, Regina Manansala, Manuel Tardaguila, Mohsen Ghanbari, Tao Jiang, Torben Hansen, Abdou Mousas, Adam S. Butterworth, Yoav Ben-Shlomo, Praveen Surendran, Terho Lehtimäki, Peter W.F. Wilson, Parsa Akbari, Hélène Choquet, Niels Grarup, Girish N. Nadkarni, Jean-Claude Tardif, Jennifer E. Huffman, Dragana Vuckovic, Ruth J. F. Loos, Karyn Megy, Emilie M. Wigdor, Michael Preuss, Alan B. Zonderman, Yukinori Okada, Oluf Pedersen, Arden Moscati, Leo-Pekka Lyytikäinen, Masahiro Kanai, Wei Huang, Andrew D Beswick, Stephen B. Watt, Erik L. Bao, Allan Linneberg, Paul Elliott, Eric Jorgenson, Tõnu Esko, Michael H. Guo, VA Million Veteran Program, Saori Sakaue, Mika Kähönen, Olli T. Raitakari, Stefan Weiss, Traci M. Bartz, Nina Mononen, Jette Bork-Jensen, Willem H. Ouwehand, Linda Broer, John Danesh, Masato Akiyama, James S. Floyd, Scott C. Ritchie, Kjell Nikus, Paul L. Auer, Emanuele Di Angelantonio, Ken Sin Lo, Kelly Cho, Uwe Völker, Ming-Huei Chen, Evangelos Evangelou, David J. Roberts, Na Cai, Benjamin Rodriguez, Savita Karthikeyan, Yoichiro Kamatani, Michael Inouye, Yoshinori Murakami, Yongmei Liu, Alexander P. Reiner, Koichi Matsuda, Jingzhong Ding, Kumaraswamy Naidu Chitrala, Niki Dimou, Andrew D. Johnson, Nathan Pankratz, Jeffrey Haessler, Vijay G. Sankaran, Oliver Stegle, Qi Guo, Karen L. Mohlke, Jennifer A. Brody, Michele K. Evans, Fotios Koskeridis, Cassandra N. Spracklen, Jerome I. Rotter, Ani Manichaikul, Patrick K. Albers, Caleb A. Lareau, Michel Georges, Hannes Ponstingl, Stephen S. Rich, Nicole Soranzo, Bruce M. Psaty, Yun Li, Klaudia Walter, Huijun Qian, Henry Völzke, Christopher J. Penkett, J. M. M. Howson, Kousik Kundu

المساهمون: Epidemiology, Internal Medicine

المصدر: 1231.e11
Cell, 182(5), 1214-1231.e11. Cell Press
Cell
Vuckovic, D, Ben-Shlomo, Y, Sankaran, V G & Soranzo, N 2020, ' The Polygenic and Monogenic Basis of Blood Traits and Diseases ', Cell, vol. 182, no. 5, pp. 1214-1231 E11 . https://doi.org/10.1016/j.cell.2020.08.008Test
Vuckovic, D, Bao, E L, Akbari, P, Lareau, C A, Mousas, A, Jiang, T, Chen, M-H, Raffield, L M, Tardaguila, M, Huffman, J E, Ritchie, S C, Megy, K, Ponstingl, H, Penkett, C J, Albers, P K, Wigdor, E M, Sakaue, S, Moscati, A, Manansala, R, Lo, K S, Qian, H, Akiyama, M, Bartz, T M, Ben-Shlomo, Y, Beswick, A, Bork-Jensen, J, Bottinger, E P, Brody, J A, van Rooij, F J A, Chitrala, K N, Wilson, P W F, Choquet, H, Danesh, J, Di Angelantonio, E, Dimou, N, Ding, J, Elliott, P, Esko, T, Evans, M K, Felix, S B, Floyd, J S, Broer, L, Grarup, N, Guo, M H, Guo, Q, Greinacher, A, Hansen, T, Linneberg, A, Pedersen, O, Loos, R J F & VA Million Veteran Program 2020, ' The Polygenic and Monogenic Basis of Blood Traits and Diseases ', Cell, vol. 182, no. 5, pp. 1214-1231 . https://doi.org/10.1016/j.cell.2020.08.008Test

مصطلحات موضوعية: Gene regulatory network, LOCI, EFFICIENT, Genome-wide association study, VARIANTS, Blood cell, 0302 clinical medicine, RARE, genetics, 11 Medical and Health Sciences, 0303 health sciences, rare diseases, Biobank, ddc, medicine.anatomical_structure, fine-mapping, VA Million Veteran Program, symbols, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, UK Biobank, polygenic risk, rare disease, Computational biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, GENETIC ARCHITECTURE, 03 medical and health sciences, symbols.namesake, splicing, blood, medicine, CELL, Allele, GENOME-WIDE ASSOCIATION, COMMON, 030304 developmental biology, Science & Technology, COMPLEX, Oxygen transport, Cell Biology, 06 Biological Sciences, Genetic architecture, hematopoiesis, INTERROGATION, Mendelian inheritance, chromatin, omnigenic, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141ceeacddd8287d8205b27678ae67a9Test

المؤلفون: Yoav Ben-Shlomo, Ming-Huei Chen, Peter Creighton Elwood, Arunoday Bhan, Mete Civelek, FinnGen Study, David-Alexandre Trégouët, Veikko Salomaa, Benjamin Rodriguez, Teemu J. Niiranen, Thorsten M. Schlaeger, Andrew D. Johnson, Andrew D Beswick, Pierre-Emmanuel Morange

المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), In press, 107 (2), pp.211-221. ⟨10.1016/j.ajhg.2020.06.008⟩
American Journal of Human Genetics, In press, 107 (2), pp.211-221. ⟨10.1016/j.ajhg.2020.06.008⟩
Am J Hum Genet
Rodriguez, B A T, Bhan, A, Beswick, A, Elwood, P C, Niiranen, T J, Salomaa, V, Trégouët, D-A, Morange, P-E, Civelek, M, Ben-Shlomo, Y, Schlaeger, T, Chen, M-H & Johnson, A D 2020, ' A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2020.06.008Test

مصطلحات موضوعية: 0301 basic medicine, Male, Platelet Aggregation, Embolism, Genome-wide association study, 030204 cardiovascular system & hematology, Pharmacology, 0302 clinical medicine, Megakaryocyte, Cardiovascular Disease, Neoplasms, Medicine, Platelet, Receptor, Lung, Genetics (clinical), Thrombin, Middle Aged, thrombin, stroke, 3. Good health, Stroke, medicine.anatomical_structure, VINTAGE, Cardiovascular Diseases, Female, medicine.drug, Signal Transduction, Platelets, Blood Platelets, venous thromboembolism, eQTL, GWA, Article, 03 medical and health sciences, Downregulation and upregulation, Mendelian randomization, Genetics, Humans, Receptor, PAR-1, Platelet activation, thrombosis, Alleles, Heart Failure, business.industry, Platelet Activation, 030104 developmental biology, Receptors, Thrombin, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed6f4d72d2a9d16e1e20ed0efb7eff0Test
https://hal.archives-ouvertes.fr/hal-03141739Test

المؤلفون: Melissa E. Garcia, Majken K. Jensen, Margaux F. Keller, Joachim H. Ix, Richard A. Jensen, Vasan S. Ramachandran, Jie Yao, Kenneth J. Mukamal, Anne B. Newman, Tamara B. Harris, Frank B. Hu, Ming-Huei Chen, Jorge R. Kizer, Bruce M. Psaty, Alice M. Arnold, James S. Pankow, Jerome I. Rotter, Ronit Katz, Luc Djoussé, David S. Siscovick, Xiuqing Guo, Mike A. Nalls, Ida Chen, Yongmei Liu, Ron C. Hoogeveen, Qi Sun, Eric B. Rimm, Mark O. Goodarzi, Marilyn C. Cornelis, Joseph M. Zmuda, Kathryn M. Rexrode

المصدر: Human molecular genetics, vol 26, iss 11

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Genotype, alpha-2-HS-Glycoprotein, Population, 030209 endocrinology & metabolism, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Medical and Health Sciences, White People, 03 medical and health sciences, Exon, 0302 clinical medicine, Diabetes Mellitus, Genetics, Humans, 2.1 Biological and endogenous factors, SNP, Polymorphism, Aetiology, education, Molecular Biology, Gene, Metabolic and endocrine, Genetics (clinical), Aged, Metabolic Syndrome, Genetics & Heredity, education.field_of_study, Association Studies Articles, Human Genome, Single Nucleotide, General Medicine, Middle Aged, Biological Sciences, Black or African American, 030104 developmental biology, Diabetes Mellitus, Type 2, Genetic Loci, Female, Type 2, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb5b598bf38b9e518ce5be416e1c53fTest
https://doi.org/10.1093/hmg/ddx091Test

المؤلفون: Kyung Ae Ko, Craig N. Morrell, Christopher J. O'Donnell, Sara Ture, Joseph M. Miano, Qiuyu Martin Zhu, Andrew D. Johnson, Michael A. Mastrangelo, Ming-Huei Chen, Charles J. Lowenstein

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 37:264-270

مصطلحات موضوعية: Blood Platelets, 0301 basic medicine, Genotype, CRISPR-Associated Proteins, Down-Regulation, Mice, Transgenic, Nerve Tissue Proteins, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Exocytosis, Article, R-SNARE Proteins, 03 medical and health sciences, 0302 clinical medicine, Von Willebrand factor, von Willebrand Factor, Animals, Humans, SNP, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Platelet activation, Blood Coagulation, Gene Editing, Genetics, biology, Thrombosis, Platelet Activation, Minor allele frequency, Disease Models, Animal, Phenotype, 030104 developmental biology, biology.protein, CRISPR-Cas Systems, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8119394b5318104d43798d132610da0eTest
https://doi.org/10.1161/atvbaha.116.308614Test