A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor
| العنوان: | A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor |
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| المؤلفون: | Kathryn Anderson, Joseph L. Jorizzo, Nicole M Ascanio, Megan A. Kinney, Daniel P. Krowchuk |
| المصدر: | Journal of Dermatological Treatment. 27:64-66 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Vulvar Squamous Cell Carcinoma, Calcineurin Inhibitors, Dermatology, Lichen sclerosus, Tacrolimus, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Retrospective analysis, Humans, Child, Glucocorticoids, Retrospective Studies, Clobetasol, business.industry, medicine.disease, Calcineurin, Lichen Sclerosus et Atrophicus, Topical corticosteroid, Child, Preschool, 030220 oncology & carcinogenesis, Chronic Disease, Standard protocol, Female, Dermatologic Agents, business, Immunosuppressive Agents |
| الوصف: | Lichen sclerosus (LS) is a chronic, inflammatory condition of the skin, affecting primarily the anogenital region potentially leading to changes in vaginal architecture and vulvar squamous cell carcinoma. Current recommended treatment for LS is high-potency corticosteroids. Calcineurin inhibitors may also have a role.The objective of this study is to introduce a treatment regimen involving clobetasol to induce remission, then tacrolimus to maintain remission in pediatric females with LS.As a retrospective case series, we report 14 pediatric females between 2 and 10 years of age with LS treated with clobetasol 0.05% topical ointment and systematically bridged to tacrolimus 0.1% topical ointment. For each patient, gender, age at disease onset, and clinical symptoms and features were noted. Time in weeks to 75% clearance and to complete clearance were recorded.Thirteen patients showed complete clearance. One patient showed significant clearance of the disease. The time to complete clearance averaged 43.1 weeks, with a range of 4-156 weeks.The use clobetasol to induce remission and tacrolimus to maintain remission can be used to treat LS in pediatric females. This regimen may minimize side effects associated with long-term, high-potency corticosteroid use and reduce the risk of changes to genital architecture secondary to LS. |
| تدمد: | 1471-1753 0954-6634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6345e60391c6f579293c4a7af780a951Test https://doi.org/10.3109/09546634.2015.1054777Test |
| رقم الانضمام: | edsair.doi.dedup.....6345e60391c6f579293c4a7af780a951 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14711753 09546634 |
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